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Hammann, C.P.W. (author), Heerkens, C.T.H. (author), Hagen, C.W. (author), Zadpoor, A.A. (author), Fratila-Apachitei, E.L. (author)Recent research evidences the strong modulatory role of controlled submicron and nanoscale topographies on stem cells fate. To harness these physical surface cues for clinical applications, fabrication of nano- and submicron patterns on clinically relevant biomaterials is greatly needed. In this study, an electron beam lithography method for...journal article 2018
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Prewett, Philip D. (author), Hagen, C.W. (author), Lenk, Claudia (author), Lenk, Steve (author), Kaestner, Marcus (author), Ivanov, Tzvetan (author), Ahmad, Ahmad (author), Robinson, A.J. (author), Hari, S. (author), Scotuzzi, M. (author)Following a brief historical summary of the way in which electron beam lithography developed out of the scanning electron microscope, three state-of-the-art charged-particle beam nanopatterning technologies are considered. All three have been the subject of a recently completed European Union Project entitled "Single Nanometre Manufacturing:...review 2018
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Durrani, Z. A.K. (author), Jones, M. E. (author), Wang, C. (author), Scotuzzi, M. (author), Hagen, C.W. (author)Nanostructures of platinum-carbon nanocomposite material have been formed by electron-beam induced deposition. These consist of nanodots and nanowires with a minimum size ∼20 nm, integrated within ∼100 nm nanogap n-type silicon-on-insulator transistor structures. The nanodot transistors use ∼20 nm Pt/C nanodots, tunnel-coupled to Pt/C...journal article 2017
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Kunze, Cindy (author), Bommer, Martin (author), Hagen, W.R. (author), Uksa, Marie (author), Dobbek, Holger (author), Schubert, Torsten (author), Diekert, Gabriele (author)The capacity of metal-containing porphyrinoids to mediate reductive dehalogenation is implemented in cobamide-containing reductive dehalogenases (RDases), which serve as terminal reductases in organohalide-respiring microbes. RDases allow for the exploitation of halogenated compounds as electron acceptors. Their reaction mechanism is under...journal article 2017
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Hagen, W.R. (author), Hagedoorn, P.L. (author), Honarmand Ebrahimi, K. (author)Biochemistry of the essential element iron is complicated by radical chemistry associated with Fe(II) ions and by the extremely low solubility of the Fe(III) ion in near-neutral water. To mitigate these problems cells from all domains of life synthesize the protein ferritin to take up and oxidize Fe(II) and to form a soluble storage of Fe(III)...journal article 2017
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Scotuzzi, M. (author), Kuipers, Jeroen (author), Wensveen, D.I. (author), De Boer, Pascal (author), Hagen, C.W. (author), Hoogenboom, J.P. (author), Giepmans, Ben N.G. (author)Cellular complexity is unraveled at nanometer resolution using electron microscopy (EM), but interpretation of macromolecular functionality is hampered by the difficulty in interpreting grey-scale images and the unidentified molecular content. We perform large-scale EM on mammalian tissue complemented with energy-dispersive X-ray analysis ...journal article 2017
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van Schie, M.M.C.H. (author), Honarmand Ebrahimi, K. (author), Hagen, Wilfred R. (author), Hagedoorn, P.L. (author)Recent developments in microfluidic and nanofluidic technologies have resulted in development of new chip-based microfluidic calorimeters with potential use in different fields. One application would be the accurate high-throughput measurement of enzyme activity. Calorimetry is a generic way to measure activity of enzymes, but unlike...journal article 2017
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Mitic, S. (author), Strampraad, M.J.F. (author), Hagen, W.R. (author), de Vries, S. (author)To afford mechanistic studies in enzyme kinetics and protein folding in the microsecond time domain we have developed a continuous-flow microsecond time-scale mixing instrument with an unprecedented dead-time of 3.8 ± 0.3 μs. The instrument employs a micro-mixer with a mixing time of 2.7 μs integrated with a 30 mm long flow-cell of 109 μm...journal article 2017
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Ragesh Kumar, T. P. (author), Hari, S. (author), Damodaran, Krishna K. (author), Ingólfsson, Oddur (author), Hagen, C.W. (author)We present first experiments on electron beam induced deposition of silacyclohexane (SCH) and dichlorosilacyclohexane (DCSCH) under a focused high-energy electron beam (FEBID). We compare the deposition dynamics observed when growing pillars of high aspect ratio from these compounds and we compare the proximity effect observed for these...journal article 2017
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Janbaz, S. (author), Noordzij, N. (author), Widyaratih, Dwisetya Safirna (author), Hagen, C.W. (author), Fratila-Apachitei, E.L. (author), Zadpoor, A.A. (author)Lattice structures are used in the design of metamaterials to achieve unusual physical, mechanical, or biological properties. The properties of such metamaterials result from the topology of the lattice structures, which are usually three-dimensionally (3D) printed. To incorporate advanced functionalities into metamaterials, the surface of the...journal article 2017
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- Bijster, R.J.F. (author), Klop, W (author), Hagen, R. (author), Sadeghian Marnani, H. (author) abstract 2016
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- Bijster, R.J.F. (author), Herfst, R. (author), Klop, W (author), Hagen, R. (author), Sadeghian Marnani, H. (author) poster 2016
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Verduin, T. (author), Lokhorst, S.R. (author), Hagen, C.W. (author), Kruit, P. (author)In the simulation of secondary electron yields (SEY) and secondary electron microscopy (SEM) images, there is always the question: are we using the correct scattering cross-sections?. The three scattering processes of interest are quasi-elastic phonon scattering, elastic Mott scattering and inelastic scattering using the dielectric function...journal article 2016
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Verduin, T. (author), Lokhorst, S.R. (author), Hagen, C.W. (author), Kruit, P. (author)We have developed a fast three dimensional Monte-Carlo framework for the investigation of shotnoise induced side-wall roughness (SWR) formation. The calculation outline is demonstrated by an example for an exposure of a 100nm thick layer of negative tone resist (NTR) resist on top of an infinitely thick silicon substrate. We use our home...conference paper 2016
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Honarmand Ebrahimi, K. (author), Bill, Eckhard (author), Hagedoorn, P.L. (author), Hagen, W.R. (author)Ferritin is a nanocage protein made of 24 subunits. Its major role is to manage intracellular concentrations of free Fe(ii) and Fe(iii) ions, which is pivotal for iron homeostasis across all domains of life. This function of the protein is regulated by a conserved di-iron catalytic center and has been the subject of extensive studies over the...journal article 2016
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Scotuzzi, M. (author), Kamerbeek, M.J. (author), Goodyear, A. (author), Cooke, M. (author), Hagen, C.W. (author)To demonstrate the possibility of using EBID masks for sub-10 nm pattern transfer into silicon, first experiments were carried out by using 20-40 nm EBID masks, that were etched by different chemistries. It is experimentally verified that recipes based on hydrogen bromide, chlorine and boron trichloride can selectively etch silicon when using 20...conference paper 2015
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- Verduin, T. (author), Lokhorst, S.R. (author), Kruit, P. (author), Hagen, C.W. (author) conference paper 2015
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Van Loon, F.D. (author), Pouderoijen, M.T. (author), Alberini, E. (author), Dijkstra, C.M. (author), Hagen, S.R. (author), De Jong, M. (author), Kiliço?lu, I.D. (author), Koukouvelou, A. (author), Mekel, M.L. (author), Schotting, K. (author), Shao, S. (author), Sun, X. (author), Terzi, O. (author), De Waal, W. (author), Van der Wal, I.A. (author), Zhang, B. (author)Booklet of the elective course AR0048 2014/2015 ‘Landscape Architecture ON site - being part of Oerol’, an elective course of the MSc2 - Chair of Landscape Architecture at the TU Delft.book 2015
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- Honarmand Ebrahimi, K. (author), Hagedoorn, P.L. (author), Hagen, W.R. (author) journal article 2015
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Ingolfsson, O. (author), Kumar, R. (author), Hagen, C.W. (author), Hari, S. (author)To study the potential role of low energy secondary electrons in focused electron beam induced deposition (FEBID) we have studied FEBID using 1,1-dichloro-1-silacyclohexane, silacyclohexane and 1,3,5-trisilacyclohexane. While the first of these compounds shows appreciable cross sections for dissociative electron attachment (DEA) in the gas phase...journal article 2015