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Bayer, Péter (author), Gatenby, Robert A. (author), McDonald, Patricia H. (author), Duckett, Derek R. (author), Staňková, K. (author), Brown, Joel S. (author)We propose a model of cancer initiation and progression where tumor growth is modulated by an evolutionary coordination game. Evolutionary games of cancer are widely used to model frequency-dependent cell interactions with the most studied games being the Prisoner's Dilemma and public goods games. Coordination games, by their more obscure and...journal article 2022
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Minissale, Marco (author), Aikawa, Yuri (author), Bergin, Edwin (author), Bertin, Mathieu (author), Brown, Wendy A. (author), Cazaux, S.M. (author), Charnley, Steven B. (author), Coutens, Audrey (author), Cuppen, Herma M. (author)The evolution of star-forming regions and their thermal balance are strongly influenced by their chemical composition, which, in turn, is determined by the physicochemical processes that govern the transition between the gas phase and the solid state, specifically icy dust grains (e.g., particle adsorption and desorption). Gas-grain and grain...review 2022
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Brown, J.M.C. (author)Over the last decade one of the most significant technological advances made in the field of radiation detectors for nuclear medicine was the development of Silicon Photomultipler (SiPM) sensors. At present only a small number of SiPM based radiation detectors for Single Photon Emission Computed Tomography (SPECT) applications have been...journal article 2021
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Brown, P.D. (author), Von Daniels, C. (author), Bocken, N.M.P. (author), Balkenende, R. (author)Circular oriented innovation commonly requires collaboration. Yet, to date, circular research lacks empirical investigation into collaborative processes. Collaborative processes are, however, highly researched within strategic management literature, thus offering valuable insights. The purpose of this paper is to investigate, identify and...journal article 2021
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Salvioli, Monica (author), Dubbeldam, J.L.A. (author), Staňková, K. (author), Brown, Joel S. (author)Fish populations subject to heavy exploitation are expected to evolve over time smaller average body sizes. We introduce Stackelberg evolutionary game theory to show how fisheries management should be adjusted to mitigate the potential negative effects of such evolutionary changes. We present the game of a fisheries manager versus a fish...journal article 2021
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Wölfl, Benjamin (author), te Rietmole, Hedy (author), Salvioli, M. (author), Kaznatcheev, Artem (author), Thuijsman, Frank (author), Brown, Joel S. (author), Burgering, Boudewijn (author), Staňková, K. (author)Evolutionary game theory mathematically conceptualizes and analyzes biological interactions where one’s fitness not only depends on one’s own traits, but also on the traits of others. Typically, the individuals are not overtly rational and do not select, but rather inherit their traits. Cancer can be framed as such an evolutionary game, as it...review 2021
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Pressley, Mariyah (author), Salvioli, Monica (author), Lewis, David B. (author), Richards, Christina L. (author), Brown, Joel S. (author), Staňková, K. (author)Rapid evolution is ubiquitous in nature. We briefly review some of this quite broadly, particularly in the context of response to anthropogenic disturbances. Nowhere is this more evident, replicated and accessible to study than in cancer. Curiously cancer has been late - relative to fisheries, antibiotic resistance, pest management and...journal article 2021
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Adams, Sophie (author), Brown, Donal (author), Cárdenas Álvarez, Juan Pablo (author), Chitchyan, Ruzanna (author), Fell, Mike (author), Hahnel, Ulf (author), Hojckova, Kristina (author), Singh, A. (author), Watson, Nicole (author)In recent years, numerous studies have explored the opportunities and challenges for emerging decentralized energy systems and business models. However, few studies have focussed specifically on the economic and social value associated with three emerging models: peer-to-peer energy trading (P2P), community self-consumption (CSC) and transactive...review 2021
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Andrews, D. R. (author), Bourne, N. K. (author), Brown, E. N. (author), Dear, J. P. (author), Dickson, P. (author), Freeman, C. J. (author), Goveas, S. G. (author), Hauser, H. (author), van der Zwaag, S. (author)Professor John Edwin Field passed away on October 21st, 2020 at the age of 84. Professor Field was widely regarded as a leader in high-strain rate physics and explosives. During his career in the Physics and Chemistry of Solids (PCS) Group of the Cavendish Laboratory at Cambridge University, John made major contributions into our...review 2021
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Routson, Cody C. (author), Kaufman, Darrell S. (author), Mckay, Nicholas P. (author), Erb, Michael P. (author), Arcusa, Stéphanie H. (author), Brown, Kendrick J. (author), Kirby, Matthew E. (author), Marsicek, Jeremiah P. (author), Schoups, G.H.W. (author)Holocene climate reconstructions are useful for understanding the diverse features and spatial heterogeneity of past and future climate change. Here we present a database of western North American Holocene paleoclimate records. The database gathers paleoclimate time series from 184 terrestrial and marine sites, including 381 individual proxy...journal article 2021
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Dujon, Antoine M. (author), Aktipis, Athena (author), Alix-Panabières, Catherine (author), Amend, Sarah R. (author), Boddy, Amy M. (author), Brown, Joel S. (author), Capp, Jean Pascal (author), DeGregori, James (author), Staňková, K. (author)The application of evolutionary and ecological principles to cancer prevention and treatment, as well as recognizing cancer as a selection force in nature, has gained impetus over the last 50 years. Following the initial theoretical approaches that combined knowledge from interdisciplinary fields, it became clear that using the eco...journal article 2021
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Brown, P.D. (author), Baldassarre, B.R. (author), Konietzko, J.C. (author), Bocken, N.M.P. (author), Balkenende, R. (author)Circular oriented innovation aims to address sustainability problems such as resource scarcity, pollution and climate change by (re)designing industrial products, processes, business models, and value network configurations. Although the literature identifies collaboration as crucial for circular oriented innovation—due to the complexity,...journal article 2021
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Brown, J.M.C. (author), Dimmock, Matthew R. (author)The production, application, and/or measurement of polarised X-/gamma rays are key to the fields of synchrotron science and X-/gamma-ray astronomy. The design, development and optimisation of experimental equipment utilised in these fields typically relies on the use of Monte Carlo radiation transport modelling toolkits such as Geant4. In...journal article 2021
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Aiello, Clarice D. (author), Awschalom, D. D. (author), Bernien, Hannes (author), Brower, Tina (author), Brown, Kenneth R. (author), Ross, R. S. (author), Singh, M. (author), Steuerman, David W. (author), Thijssen, J.M. (author)Interest in building dedicated quantum information science and engineering (QISE) education programs has greatly expanded in recent years. These programs are inherently convergent, complex, often resource intensive and likely require collaboration with a broad variety of stakeholders. In order to address this combination of challenges, we...review 2021
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Brown, P.D. (author)Our society faces many global sustainability challenges. Many of these challenges we have either created or exacerbated by not thinking about how the scale of our actions impacts the planet. We have however entered the Anthropocene, an epoch in time whereby human activity is now the dominant force upon the planet’s climate and environment. It is...doctoral thesis 2020
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Baldassarre, B.R. (author), Konietzko, J.C. (author), Brown, P.D. (author), Calabretta, G. (author), Bocken, N.M.P. (author), Karpen, Ingo O. (author), Hultink, H.J. (author)Next to the redesign of industrial products and processes, sustainable business model innovation is a strategic approach to integrate environmental and social concerns into the objectives and operations of organizations. One of the major challenges of this approach is that many promising business model ideas fail to reach the market, which is...journal article 2020
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van Bijsterveldt, Celine E.J. (author), van Wesenbeeck, B (author), van der Wal, Daphne (author), Afiati, Norma (author), Pribadi, Rudhi (author), Brown, Benjamin (author), Bouma, Tjeerd J. (author)Globally, erosion of muddy tropical coasts that are dominated by aquaculture ponds, is an increasing problem. Restoration of mangrove greenbelts may counteract such erosion, by restoring the sediment balance. Hence, we aim to unravel the processes controlling natural mangrove regeneration in both “landward” (i.e., into aquaculture ponds) and...journal article 2020
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Sterckx, Sindy (author), Brown, Ian (author), Kääb, Andreas (author), Krol, Maarten (author), Morrow, Rosemary (author), Veefkind, j. Pepijn (author), Boersma, K. Folkert (author), De Mazière, Martine (author), Fox, Nigel (author), Thorne, Peter (author)Societal dependence on, and commercial and scientific exploitation of Earth-Oriented remote sensing from satellites is growing at an exponential rate. The comprehensive EU Copernicus programme provides a major contribution to the global effort, but even so, to achieve the necessary global and temporal coverage requires synergistic cooperation...review 2020
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Brown, P.D. (author), Bocken, N.M.P. (author), Balkenende, R. (author)Collaborative innovation is necessary to explore and implement circular economy strategies. Yet, empirical investigations into such collaborations are scarce. It is unclear whether the circular context creates differences or represents adaptions within how collaborative innovation is conducted. We draw upon strategic management and open...journal article 2020
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Optimal control to reach eco-evolutionary stability in metastatic castrate-resistant prostate cancerCunningham, Jessica (author), Thuijsman, Frank (author), Peeters, Ralf (author), Viossat, Yannick (author), Brown, Joel (author), Gatenby, Robert (author), Staňková, K. (author)In the absence of curative therapies, treatment of metastatic castrate-resistant prostate cancer (mCRPC) using currently available drugs can be improved by integrating evolutionary principles that govern proliferation of resistant subpopulations into current treatment protocols. Here we develop what is coined as an ‘evolutionary stable...journal article 2020