Top-Down, Knowledge-Based Genetic Reduction of Yeast Central Carbon Metabolism

Saccharomyces cerevisiae, whose evolutionary past includes a whole-genome duplication event, is characterized by a mosaic genome configuration with substantial apparent genetic redundancy. This apparent redundancy raises questions about the evolutionary driving force for genomic fixation of “minor” paralogs and complicates modular and...

Improving Industrially Relevant Phenotypic Traits by Engineering Chromosome Copy Number in Saccharomyces pastorianus

The lager-brewing yeast Saccharomyces pastorianus is a hybrid between S. cerevisiae and S. eubayanus with an exceptional degree of aneuploidy. While chromosome copy number variation (CCNV) is present in many industrial Saccharomyces strains and has been linked to various industrially-relevant traits, its impact on the brewing performance of S...

Characterization of a multi-pinhole molecular breast tomosynthesis scanner

In recent years, breast imaging using radiolabelled molecules has attracted significant interest. Our group has proposed a multi-pinhole molecular breast tomosynthesis (MP-MBT) scanner to obtain 3D functional molecular breast images at high resolutions. After conducting extensive optimisation studies using simulations, we here present a first...

Modelling, Simulation, and Optimization of Molecular Breast Tomosynthesis

In this thesis, we developed tools to model and simulate single gamma imaging modalities. These tools were subsequently used to simulate and optimize a design for Molecular Breast Tomosynthesis (MBT). The chapters in this thesis can be divided into two groups. The first group consists of Chapters 3 and 4 detailing technical topics concerning...

Comparison of fan-beam, slit-slat and multi-pinhole collimators for molecul breast tomosynthesis

Recently, we proposed and optimized dedicated multi-pinhole molecular breast tomosynthesis (MBT) that images a lightly compressed breast. As MBT may also be performed with other types of collimators, the aim of this paper is to optimize MBT with fan beam and slit-slat collimators and to compare its performance to that of multi-pinhole MBT to...

Digging4Data: How to do research on the built environment in Indonesia, 1620-1950

The other ‘other’: Re-framing and re-defining research on Southeast Asian colonial and postcolonial architecture and urbanism

Digging4Data: Bagaimana meneliti lingkungan terbangun di Indonesia, 1620-1950

Non-diverging analytical expression for the sensitivity of converging SPECT collimators

Accurate analytical expressions for collimator resolution and sensitivity are important tools in the optimization of SPECT systems. However, presently known expressions for the sensitivity of converging collimators either diverge near the focal point or focal line(s), or are only valid on the collimator axis. As a result, these expressions...

Optimizing modelling in iterative image reconstruction for preclinical pinhole PET

The recently developed versatile emission computed tomography (VECTor) technology enables high-energy SPECT and simultaneous SPECT and PET of small animals at sub-mm resolutions. VECTor uses dedicated clustered pinhole collimators mounted in a scanner with three stationary large-area NaI(Tl) gamma detectors. Here, we develop and validate...

Laura Victoir and Victor Zatsepine (eds), Harbin to Hanoi: The Colonial Built Environment in Asia, 1840 to 1940

Hong Kong University Press, Hong Kong, 2013, ISBN 978-988-8139-41-5 (hardback); ISBN 978-988-8139-42-2 (paperback).

Bouwen in turbulente tijden: Het werk van Ingenieurs-Bureau Ingenegeren-Vrijburg (IBIV) (1936-1957)

Op 1 mei 1936 openden de Nederlandse ingenieurs A.C. Ingenegeren en G.S. Vrijburg in Nederlands-Indië de deuren van Ingenieurs-Bureau Ingenegeren-Vrijburg (IBIV) (afb.2 ). Het in Bandoeng gevestigde IBIV zou bestaan tot 1957. De bestaansperiode van het bureau viel samen met politiek turbulente jaren: de nadagen van het koloniale Nederlandse...

Embedded coring in MPEG video compression

Correction of intensity flicker in old film sequences

Gecombineerd vervoer over water

Ship concepts for improved transport chain efficiency

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