Resilience and resistance to the accumulation of amyloid plaques and neurofibrillary tangles in centenarians: An age-continuous perspective

Introduction: With increasing age, neuropathological substrates associated with Alzheimer's disease (AD) accumulate in brains of cognitively healthy individuals—are they resilient, or resistant to AD-associated neuropathologies?. Methods: In 85 centenarian brains, we correlated NIA (amyloid) stages, Braak (neurofibrillary tangle) stages, and...

Evolutionary Dynamics of Treatment-Induced Resistance in Cancer Informs Understanding of Rapid Evolution in Natural Systems

Rapid evolution is ubiquitous in nature. We briefly review some of this quite broadly, particularly in the context of response to anthropogenic disturbances. Nowhere is this more evident, replicated and accessible to study than in cancer. Curiously cancer has been late - relative to fisheries, antibiotic resistance, pest management and...

A Chip Integrity Monitor for Evaluating Moisture/Ion Ingress in mm-Sized Single-Chip Implants

For mm-sized implants incorporating silicon integrated circuits, ensuring lifetime operation of the chip within the corrosive environment of the body still remains a critical challenge. For the chip's packaging, various polymeric and thin ceramic coatings have been reported, demonstrating high biocompatibility and barrier properties. Yet, for...

Numerical analysis of added resistance on ships in short waves

Behaviour of high strength steel moment joints

The design of joints to European standard EN 1993 within the semi-continuous/partially restrained philosophy is restricted to steel grades up to S460. With the recent development of high performance steels, the need for these restrictions should be revisited. The semicontinuous joint modelling can be adopted as long as the joint develops...

Aspects of the cavitating propeller tip vortex as a source of inboard noise and vibration

Thin films of the charge-density-wave oxide Rb(0.30) MoO(3) by pulsed-laser deposition

Thin-film growth of the charge-density-wave oxide Rb0.30MoO3

Estimation of resistance, trim and draft of planing craft

Low-frequency noise of quantum point contacts in the ballistic and quantum Hall regime

Spontaneous resistance switching and low-frequency noise in quantum point contacts

Analysis of wave resistance in the design of the 12-meter yacht STARS & STRIPES

The Analysis of wave resistance in the design of the 12-meter yacht STARS & STRIPES