Alkaliphilic Life: Adaptation strategies by Caldalkalibacillus thermarum

Alkaliphiles thrive in environments with a pH of 8.5 or above, while maintaining an internal pH closer to neutral. Thus, alkaliphilic microorganisms have a proton gradient inverted with respect to the normal orientation. Intuitively, this would nullify the potential to generate energy via respiration with regularly oriented respiratory chains...

High-Performance Cluster-Scalable Computational Methods for Genomics Applications

The ever increasing pace of advancements in sequencing technologies has enabled rapid DNA/genome sequencing to become much more accessible. In particular, next (second) and third generation sequencing technologies offer high throughput, massively parallel and cost effective sequencing solutions. Individual sample sequencing data volumes as well...