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Simoes dos Santos, D. (author), Ossenkoppele, B.W. (author), Hopf, Y.M. (author), Soozande, Mehdi (author), Noothout, E.C. (author), Vos, H.J. (author), Bosch, Johan G. (author), Pertijs, M.A.P. (author), Verweij, M.D. (author), de Jong, N. (author)Objective: Described here is the development of an ultrasound matrix transducer prototype for high-frame-rate 3-D intra-cardiac echocardiography. Methods: The matrix array consists of 16 × 18 lead zirconate titanate elements with a pitch of 160 µm × 160 µm built on top of an application-specific integrated circuit that generates transmission...journal article 2024
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Simoes dos Santos, D. (author), Baldini, L.B. (author), Vos, H.J. (author), Verweij, M.D. (author), de Jong, N. (author), van Neer, P.L.M.J. (author)The accurate determination of the transfer function of ultrasound transducers is important for their design and operational performance. However, conventional methods for quantifying the transfer function, such as hydrophone measurements, radiation force balance, and pulse-echo measurements, are costly and complex due to specialized equipment...journal article 2024
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Hopf, Y.M. (author), Simoes dos Santos, D. (author), Ossenkoppele, Boudewine W. (author), Noothout, E.C. (author), Chang, Z.Y. (author), Chen, Chao (author), Vos, H.J. (author), Verweij, M.D. (author), de Jong, N. (author), Pertijs, M.A.P. (author)This article presents an application-specific integrated circuit (ASIC) for catheter-based 3-D ultrasound imaging probes. The pitch-matched design implements a comprehensive architecture with high-voltage (HV) transmitters, analog front ends, hybrid beamforming analog-To-digital converters (ADCs), and data transmission to the imaging system....journal article 2024
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Guo, P. (author), Fool, F. (author), Chang, Z.Y. (author), Noothout, E.C. (author), Vos, H.J. (author), Bosch, Johan G. (author), de Jong, N. (author), Verweij, M.D. (author), Pertijs, M.A.P. (author)This article presents a low-power and small-area transceiver application-specific integrated circuit (ASIC) for 3-D trans-fontanelle ultrasonography. A novel micro-beamforming receiver architecture that employs current-mode summation and boxcar integration is used to realize delay-and-sum on an N -element sub-array using N× fewer capacitive...journal article 2023
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Zangabad, Reza Pakdaman (author), Li, H. (author), Kouijzer, Joop J.P. (author), Langeveld, Simone A.G. (author), Beekers, Ines (author), Verweij, M.A. (author), de Jong, N. (author), Kooiman, Klazina (author)Understanding and controlling the ultrasound contrast agent (UCA)'s response to an applied ultrasound pressure field are crucial when investigating ultrasound imaging sequences and therapeutic applications. The magnitude and frequency of the applied ultrasonic pressure waves affect the oscillatory response of the UCA. Therefore, it is...journal article 2023
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Wei, Luxi (author), Wahyulaksana, G. (author), Boni, Enrico (author), Noothout, E.C. (author), Duncker, Dirk J. (author), Tortoli, Piero (author), van der Steen, A.F.W. (author), de Jong, N. (author), Verweij, M.D. (author), Vos, H.J. (author)Objective: The aim of this study was to assess the feasibility and imaging options of contrast-enhanced volumetric ultrasound kidney vasculature imaging in a porcine model using a prototype sparse spiral array. Methods: Transcutaneous freehand in vivo imaging of two healthy porcine kidneys was performed according to three protocols with...journal article 2023
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Ossenkoppele, B.W. (author), Luijten, Ben (author), Bera, Deep (author), de Jong, N. (author), Verweij, M.A. (author), van Sloun, Ruud J.G. (author)There is an increased desire for miniature ultrasound probes with small apertures to provide volumetric images at high frame rates for in-body applications. Satisfying these increased requirements makes simultaneous achievement of a good lateral resolution a challenge. As micro-beamforming is often employed to reduce data rate and cable count...journal article 2023
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Li, H. (author), Li, X. (author), Collado Lara, G. (author), Lattwein, K.R. (author), Mastik, Frits (author), Beurskens, Robert (author), van der Steen, A.F.W. (author), Verweij, M.A. (author), de Jong, N. (author), Kooiman, Klazina (author)Ultrasound contrast-mediated medical imaging and therapy both rely on the dynamics of micron- and nanometer-sized ultrasound cavitation nuclei, such as phospholipid-coated microbubbles and phase-change droplets. Ultrasound cavitation nuclei respond non-linearly to ultrasound on a nanosecond time scale that necessitates the use of ultra-high...journal article 2023
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Massaad Mouawad, J.M. (author), van Neer, P.L.M.J. (author), van Willigen, D.M. (author), Pertijs, M.A.P. (author), de Jong, N. (author), Verweij, M.D. (author)Clamp-on ultrasonic flow meters (UFMs) are installed on the outside of the pipe wall. Typically, they consist of two single-element transducers mounted on angled wedges, which are acoustically coupled to the pipe wall. Before flow metering, the transducers are placed at the correct axial position by manually moving one transducer along the pipe...journal article 2022
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Mozaffarzadeh, M. (author), Verweij, M.D. (author), de Jong, N. (author), Renaud, G.G.J. (author)While transcranial ultrasound imaging is a promising diagnostic modality, it is still hindered due to phase aberration and multiple scattering caused by the skull. In this paper, we compare near-field phase-screen modeling (PS) to a geometry-based phase aberration correction technique (GB) when an ultrafast imaging sequence (five plane waves...journal article 2022
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Hopf, Y.M. (author), Ossenkoppele, B.W. (author), Soozande, M. (author), Noothout, E.C. (author), Chang, Z.Y. (author), Vos, H.J. (author), Bosch, Johan G. (author), Verweij, M.D. (author), de Jong, N. (author), Pertijs, M.A.P. (author)In this letter, a compact high-voltage (HV) transmit circuit for dense 2-D transducer arrays used in 3-D ultrasonic imaging systems is presented. Stringent area requirements are addressed by a unipolar pulser with embedded transmit/receive switch. Combined with a capacitive HV level shifter, it forms the ultrasonic HV...journal article 2022
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Internalization of targeted microbubbles by endothelial cells and drug delivery by pores and tunnelsBeekers, Inés (author), Langeveld, Simone A.G. (author), Meijlink, Bram (author), van der Steen, A.F.W. (author), de Jong, N. (author), Verweij, M.D. (author), Kooiman, Klazina (author)Ultrasound insonification of microbubbles can locally enhance drug delivery by increasing the cell membrane permeability. To aid development of a safe and effective therapeutic microbubble, more insight into the microbubble-cell interaction is needed. In this in vitro study we aimed to investigate the initial 3D morphology of the endothelial...journal article 2022
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Mozaffarzadeh, M. (author), Verschuur, D.J. (author), Verweij, M.D. (author), de Jong, N. (author), Renaud, G.G.J. (author)In a recent study, we proposed a technique to correct aberration caused by the skull and reconstruct a transcranial B-mode image with a refraction-corrected synthetic aperture imaging (SAI) scheme. Given a sound speed map, the arrival times were calculated using a fast marching technique (FMT), which solves the Eikonal equation and, therefore...journal article 2022
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Deurvorst, F.R. (author), Collado Lara, G. (author), Matalliotakis, A. (author), Vos, H.J. (author), de Jong, N. (author), Daeichin, V. (author), Verweij, M.D. (author)An in vivo range verification technology for proton beam cancer therapy, preferably in real-time and with submillimeter resolution, is desired to reduce the present uncertainty in dose localization. Acoustical imaging technologies exploiting possible local interactions between protons and microbubbles or nanodroplets might be an interesting...journal article 2022
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Simoes dos Santos, D. (author), Fool, F. (author), Mozaffarzadeh, M. (author), Shabanimotlagh, M. (author), Noothout, E.C. (author), Kim, T. (author), Rozsa, N.N.M. (author), Vos, H.J. (author), Bosch, Johan G. (author), Pertijs, M.A.P. (author), Verweij, M.D. (author), de Jong, N. (author)High frame rate three-dimensional (3D) ultrasound imaging would offer excellent possibilities for the accurate assessment of carotid artery diseases. This calls for a matrix transducer with a large aperture and a vast number of elements. Such a matrix transducer should be interfaced with an application-specific integrated circuit (ASIC) for...journal article 2022
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Wei, Luxi (author), Boni, Enrico (author), Ramalli, Alessandro (author), Fool, F. (author), Noothout, E.C. (author), van der Steen, A.F.W. (author), Verweij, M.D. (author), Tortoli, Piero (author), de Jong, N. (author), Vos, H.J. (author)Two-dimensional (2-D) arrays offer volumetric imaging capabilities without the need for probe translation or rotation. A sparse array with elements seeded in a tapering spiral pattern enables one-to-one connection to an ultrasound machine, thus allowing flexible transmission and reception strategies. To test the concept of sparse spiral array...journal article 2022
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Soozande, Mehdi (author), Ossenkoppele, B.W. (author), Hopf, Y.M. (author), Pertijs, M.A.P. (author), Verweij, M.D. (author), de Jong, N. (author), Vos, H.J. (author), Bosch, Johan G. (author)Atrial fibrillation (AF) is the most common cardiac arrhythmia and is normally treated by RF ablation. Intracardiac echography (ICE) is widely employed during RF ablation procedures to guide the electrophysiologist in navigating the ablation catheter, although only 2-D probes are currently clinically used. A 3-D ICE catheter would not only...journal article 2022
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Massaad Mouawad, J.M. (author), van Neer, P.L.M.J. (author), van Willigen, D.M. (author), Noothout, E.C. (author), de Jong, N. (author), Pertijs, M.A.P. (author), Verweij, M.D. (author)Common clamp-on ultrasonic flow meters consist of two single-element transducers placed on the pipe wall. Flow speed is measured noninvasively, i.e., without interrupting the flow and without perforating the pipe wall, which also minimizes safety risks and avoids pressure drops inside the pipe. However, before metering, the transducers have...journal article 2022
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Massaad Mouawad, J.M. (author), van Neer, P.L.M.J. (author), van Willigen, D.M. (author), Pertijs, M.A.P. (author), de Jong, N. (author), Verweij, M.D. (author)Ultrasonic flow meters (UFMs) based on transducer arrays offer several advantages. With electronic beam steering, it is possible to tune the steering angle of the beam for optimal signal-tonoise ratio (SNR) upon reception. Moreover, multiple beams can be generated to propagate through different travel paths, covering a wider section of the...journal article 2022
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Sabbadini, A. (author), Massaad Mouawad, J.M. (author), van Neer, P.L.M.J. (author), de Jong, N. (author), Verweij, M.D. (author)In recent years, several fitting techniques have been presented to reconstruct the parameters of a plate from its Lamb wave dispersion curves. Published studies show that these techniques can yield high accuracy results and have the potential of reconstructing several parameters at once. The precision with which parameters can be...journal article 2022