High-Frame-Rate Volumetric Porcine Renal Vasculature Imaging

High-Frame-Rate Volumetric Porcine Renal Vasculature Imaging

Wei, Luxi (Erasmus MC)
Wahyulaksana, G. (Erasmus MC)
Boni, Enrico (University of Florence)
Noothout, E.C. (TU Delft ImPhys/Verweij group)
Duncker, Dirk J.
Tortoli, Piero (University of Florence)
van der Steen, A.F.W. (TU Delft ImPhys/Medical Imaging; TU Delft ImPhys/Verweij group; Erasmus MC)
de Jong, N. (TU Delft ImPhys/De Jong group; Erasmus MC)
Verweij, M.D. (TU Delft ImPhys/Medical Imaging; TU Delft ImPhys/Verweij group; Erasmus MC)
Vos, H.J. (TU Delft ImPhys/Verweij group; Erasmus MC)

2023

Objective: The aim of this study was to assess the feasibility and imaging options of contrast-enhanced volumetric ultrasound kidney vasculature imaging in a porcine model using a prototype sparse spiral array. Methods: Transcutaneous freehand in vivo imaging of two healthy porcine kidneys was performed according to three protocols with different microbubble concentrations and transmission sequences. Combining high-frame-rate transmission sequences with our previously described spatial coherence beamformer, we determined the ability to produce detailed volumetric images of the vasculature. We also determined power, color and spectral Doppler, as well as super-resolved microvasculature in a volume. The results were compared against a clinical 2-D ultrasound machine. Results: Three-dimensional visualization of the kidney vasculature structure and blood flow was possible with our method. Good structural agreement was found between the visualized vasculature structure and the 2-D reference. Microvasculature patterns in the kidney cortex were visible with super-resolution processing. Blood flow velocity estimations were within a physiological range and pattern, also in agreement with the 2-D reference results. Conclusion: Volumetric imaging of the kidney vasculature was possible using a prototype sparse spiral array. Reliable structural and temporal information could be extracted from these imaging results.

3-D ultrasound
Contrast-enhanced
High frame rate
In vivo
Kidney
Vasculature
Volumetric

http://resolver.tudelft.nl/uuid:2691bfd9-0c5f-4f34-b6fd-b5ed2ab3121a

https://doi.org/10.1016/j.ultrasmedbio.2023.08.009

0301-5629

Ultrasound in Medicine & Biology, 49 (12), 2476-2482

Institutional Repository

journal article

© 2023 Luxi Wei, G. Wahyulaksana, Enrico Boni, E.C. Noothout, Dirk J. Duncker, Piero Tortoli, A.F.W. van der Steen, N. de Jong, M.D. Verweij, H.J. Vos, More Authors