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Determinants of carotid atherosclerotic plaque burden in a stroke-free population

Selwaness, Mariana (author), Hameeteman, Reinhard (author), Van 't Klooster, Ronald (author), Van den Bouwhuijsen, Quirijn (author), Hofman, Albert (author), Franco, Oscar H. (author), Niessen, W.J. (author), Klein, Stefan (author), Vernooij, Meike W. (author), Van der Lugt, Aad (author), Wentzel, Jolanda J. (author)

Background and aims In a large stroke-free population, we sought to identify cardiovascular risk factors and carotid plaque components associated with carotid plaque burden, lumen volume and stenosis. Methods The carotid arteries of 1562 stroke-free participants from The Rotterdam Study were imaged on a 1.5-Tesla MRI scanner. Inner and outer...

journal article 2016

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Multiparametric computer-aided differential diagnosis of Alzheimer’s disease and frontotemporal dementia using structural and advanced MRI

Bron, Esther E. (author), Smits, Marion (author), Papma, Janne M. (author), Steketee, Rebecca M E (author), Meijboom, Rozanna (author), De Groot, Marius (author), van Swieten, John C. (author), Niessen, W.J. (author), Klein, S. (author)

Objectives: To investigate the added diagnostic value of arterial spin labelling (ASL) and diffusion tensor imaging (DTI) to structural MRI for computer-aided classification of Alzheimer's disease (AD), frontotemporal dementia (FTD), and controls. Methods: This retrospective study used MRI data from 24 early-onset AD and 33 early-onset FTD...

journal article 2016

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Cas3-Derived Target DNA Degradation Fragments Fuel Primed CRISPR Adaptation

Künne, Tim (author), Kieper, S.N. (author), Bannenberg, Jasper W. (author), Vogel, Anne I M (author), Miellet, Willem R. (author), Klein, M. (author), Depken, S.M. (author), Suarez-Diez, Maria (author), Brouns, S.J.J. (author)

Prokaryotes use a mechanism called priming to update their CRISPR immunological memory to rapidly counter revisiting, mutated viruses, and plasmids. Here we have determined how new spacers are produced and selected for integration into the CRISPR array during priming. We show that Cas3 couples CRISPR interference to adaptation by producing...

journal article 2016

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Image formation properties and inverse imaging problem in aperture based scanning near field optical microscopy

Schmidt, S. (author), Klein, A. E. (author), Paul, T. (author), Gross, H. (author), Diziain, S. (author), Steinert, M. (author), da Costa Assafrao, A. (author), Pertsch, T. (author), Urbach, Paul (author), Rockstuhl, C. (author)

Aperture based scanning near field optical microscopes are important instruments to study light at the nanoscale and to understand the optical functionality of photonic nanostructures. In general, a detected image is affected by both the transverse electric and magnetic field components of light. The discrimination of the individual field...

journal article 2016

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Relaxation of the resistive superconducting state in boron-doped diamond films

Kardakova, A. (author), Shishkin, A. (author), Semenov, A. (author), Goltsman, G.N. (author), Ryabchun, S. (author), Klapwijk, T.M. (author), Bousquet, J. (author), Eon, D. (author), Sacépé, B. (author), Klein, T. (author), Bustarret, E. (author)

We report a study of the relaxation time of the restoration of the resistive superconducting state in single crystalline boron-doped diamond using amplitude-modulated absorption of (sub-)THz radiation (AMAR). The films grown on an insulating diamond substrate have a low carrier density of about 2.5×1021cm?3 and a critical temperature of about 2K...

journal article 2016

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Warmteterugwinning met hybride ventilatiesysteem

Scholten, R.D. (author), Engel, P. (author), Klein, T. (author)

journal article 2015

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XNAT imaging platform for BioMedBridges and CTMM TraIT (meeting abstract)

Klein, S. (author), Vast, E. (author), Van Soest, J. (author), Dekker, A. (author), Koek, M. (author), Niessen, W.J. (author)

1st Clinical Research Informatics (CRI) Solutions Day Duesseldorf, Germany, 26-27 May 2014

journal article 2015

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Atherosclerotic Plaque Component Segmentation in Combined Carotid MRI and CTA Data Incorporating Class Label Uncertainty

Van Engelen, A. (author), Niessen, W.J. (author), Klein, S. (author), Groen, H.C. (author), Verhagen, H.J.M. (author), Wentzel, J.J. (author), Van der Lugt, A. (author), De Bruijne, M. (author)

Atherosclerotic plaque composition can indicate plaque vulnerability. We segment atherosclerotic plaque components from the carotid artery on a combination of in vivo MRI and CT-angiography (CTA) data using supervised voxelwise classification. In contrast to previous studies the ground truth for training is directly obtained from 3D registration...

journal article 2014

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The other drones; looking at the other drone use possibilities

Klein, R. (author)

Most people will think of the MQ-9 Reaper, when mentioning drones. This is the drone that is used by the United States Air Force and the CIA in Pakistan, Yemen and Somalia to kill terrorists. Most of the time, these drones are mentioned in the news for their collateral damage. In 2013 alone, the United States estimated that 271 people died from...

journal article 2014

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Fast parallel image registration on CPU and GPU for diagnostic classification of Alzheimer's disease

Shamonin, D.P. (author), Bron, E.E. (author), Lelieveldt, B.P.F. (author), Smits, M. (author), Klein, S. (author), Staring, M. (author)

Nonrigid image registration is an important, but time-consuming task in medical image analysis. In typical neuroimaging studies, multiple image registrations are performed, i.e., for atlas-based segmentation or template construction. Faster image registration routines would therefore be beneficial. In this paper we explore acceleration of the...

journal article 2014

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TU students sweep UAV design competition

Klein, R. (author), Brust, S. (author), Brown, M. (author), Vos, R. (author)

To design a high-altitude long-endurance UAV to fly a twenty-hour reconnaissance mission at an altitude of 80,000ft, was the assignment for this year’s undergraduate design competition. The competition was organized by the American Institute of Aeronautics and Astronautics (AIAA). Three students from Delft demonstrated superior design skills,...

journal article 2013

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Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) shows no change in cartilage structural composition after viscosupplementation in patients with early-stage knee osteoarthritis

Van Tiel, J. (author), Reijman, M. (author), Bos, P.K. (author), Hermans, J. (author), Van Buul, G.M. (author), Bron, E.E. (author), Klein, S. (author), Verhaar, J.A.N. (author), Krestin, G.P. (author), Bierma-Zeinstra, S.M.A. (author), Weinans, H. (author), Kotek, G. (author), Oei, E.H.G. (author)

journal article 2013

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High precision wavelength estimation method for integrated optics

Oldenbeuving, R.M. (author), Song, H. (author), Schitter, G. (author), Verhaegen, M.H.G. (author), Klein, E.J. (author), Lee, C.J. (author), Offerhaus, H.L. (author), Boller, K.J. (author)

A novel and simple approach to optical wavelength measurement is presented in this paper. The working principle is demonstrated using a tunable waveguide micro ring resonator and single photodiode. The initial calibration is done with a set of known wavelengths and resonator tunings. The combined spectral sensitivity function of the resonator...

journal article 2013

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Improving alignment in Tract-based spatial statistics: Evaluation and optimization of image registration

De Groot, M. (author), Vernooij, M.W. (author), Klein, S. (author), Arfan Ikram, M. (author), Vos, F.M. (author), Smith, S.M. (author), Niessen, W.J. (author), Andersson, J.L.R. (author)

Anatomical alignment in neuroimaging studies is of such importance that considerable effort is put into improving the registration used to establish spatial correspondence. Tract-based spatial statistics (TBSS) is a popular method for comparing diffusion characteristics across subjects. TBSS establishes spatial correspondence using a combination...

journal article 2013

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Implications of the law on video recording in clinical practice

Henken, K.R. (author), Jansen, F.W. (author), Klein, J. (author), Stassen, L.P.S. (author), Dankelman, J. (author), Van den Dobbelsteen, J.J. (author)

Background Technological developments allow for a variety of applications of video recording in health care, including endoscopic procedures. Although the value of video registration is recognized, medicolegal concerns regarding the privacy of patients and professionals are growing. A clear understanding of the legal framework is lacking....

journal article 2012

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Balanced ternary addition using a gated silicon nanowire

Mol, J.A. (author), Van der Heijden, J. (author), Verduijn, J. (author), Klein, M. (author), Remacle, F. (author), Rogge, S. (author)

Ternary logic has the lowest cost of complexity, here, we demonstrate a CMOS hardware implementation of a ternary adder using a silicon metal-on-insulator single electron transistor. Gate dependent rectifying behavior of a single electron transistor (SET) results in a robust three-valued output as a function of the potential of the single...

journal article 2011

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Facilitating tumor functional assessment by spatially relating 3D tumor histology and in vivo MRI: Image registration approach

Alic, L. (author), Haeck, J.C. (author), Bol, K. (author), Klein, S. (author), Van Tiel, S.T. (author), Wielepolski, P.A. (author), De Jong, M. (author), Niessen, W.J. (author), Bernsen, M. (author), Veenland, J.F. (author)

Background Magnetic resonance imaging (MRI), together with histology, is widely used to diagnose and to monitor treatment in oncology. Spatial correspondence between these modalities provides information about the ability of MRI to characterize cancerous tissue. However, registration is complicated by deformations during pathological processing,...

journal article 2011

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Estimating 3D lumen centerlines of carotid arteries in free-hand acquisition ultrasound

Carvalho, D.D.B. (author), Klein, S. (author), Akkus, Z. (author), Ten Kate, G.L. (author), Schinkel, A.F.L. (author), Bosch, J.G. (author), Van der Lugt, A. (author), Niessen, W.J. (author)

Purpose The purpose of this paper is to present a methodology to estimate the carotid artery lumen centerlines in ultrasound (US) images obtained in a free-hand examination. Challenging aspects here are speckle noise in US images, artifacts, and the lack of contrast in the direction orthogonal to the US beam direction. Method An algorithm based...

journal article 2011

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High-resolution heterodyne spectroscopy using a tunable quantum cascade laser around 3.5 THz

Ren, Y. (author), Hovenier, J.N. (author), Higgins, R. (author), Gao, J.R. (author), Klapwijk, T.M. (author), Shi, S.C. (author), Klein, B. (author), Kao, T.Y. (author), Hu, Q. (author), Reno, J.L. (author)

A frequency tunable terahertz heterodyne spectrometer, based on a third-order distributed feedback quantum cascade laser as a local oscillator, has been demonstrated by measuring molecular spectral lines of methanol (CH3OH) gas at 3.5 THz. By varying the bias voltage of the laser, we achieved a tuning range of ? 1?GHz of the lasing frequency,...

journal article 2011

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Discrepant perceptions of communication, teamwork and situation awareness among surgical team members

Wauben, L.S.G.L. (author), Dekker-van Doorn, C.M. (author), Van Wijngaarden, J.H.D. (author), Goossens, R.H.M. (author), Huijsman, R. (author), Klein, J. (author), Lange, J.F. (author)

Objective To assess surgical team members’ differences in perception of non-technical skills. Design Questionnaire design. Setting Operating theatres (OTs) at one university hospital, three teaching hospitals and one general hospital in the Netherlands. Participants Sixty-six surgeons, 97 OT nurses, 18 anaesthetists and 40 nurse anaesthetists....

journal article 2011