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Evans, Tavia E. (author), O'Sullivan, Michael J. (author), De Groot, Marius (author), Niessen, W.J. (author), Hofman, Albert (author), Krestin, Gabriel P. (author), Van Der Lugt, Aad (author), Portegies, Marileen L P (author), Koudstaal, Peter J. (author), Bos, Daniel (author), Vernooij, Meike W. (author), Ikram, M. Arfan (author)Background and Purpose - The presence of subclinical vascular brain disease, including white matter lesions and lacunar infarcts, substantially increases the risk of clinical stroke. White matter microstructural integrity is considered an earlier, potentially better, marker of the total burden of vascular brain disease. Its association with...journal article 2016
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Roshchupkin, G. V. (author), Adams, H. H H (author), Vernooij, M. W. (author), Hofman, A. (author), Van Duijn, C. M. (author), Ikram, M. A. (author), Niessen, W.J. (author)High-throughput technology can now provide rich information on a person's biological makeup and environmental surroundings. Important discoveries have been made by relating these data to various health outcomes in fields such as genomics, proteomics, and medical imaging. However, cross-investigations between several high-throughput...journal article 2016
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- Santos, E.M.M. (author), Niessen, W.J. (author), Yoo, A.J. (author), Berkhemer, O.A. (author), Beenen, L.F. (author), Majoie, C.B. (author), Marquering, H.A. (author) journal article 2016
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Huizinga, W. (author), Poot, D.H.J. (author), Roshchupkin, G. (author), Bron, E. E. (author), Ikram, M. A. (author), Vernooij, M. W. (author), Rueckert, D. (author), Niessen, W.J. (author), Klein, S. (author)Both normal aging and neurodegenerative diseases such as Alzheimer's disease cause morphological changes of the brain. To better distinguish between normal and abnormal cases, it is necessary to model changes in brain morphology owing to normal aging. To this end, we developed a method for analyzing and visualizing these changes for the...conference paper 2016
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- Schmaal, L. (author), Veltman, D. J. (author), Van Erp, T. G M (author), Smann, P. G. (author), Frodl, T. (author), Jahanshad, N. (author), Loehrer, E. (author), Vernooij, M. W. (author), Niessen, W.J. (author), Ikram, M. A. (author) journal article 2016
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Koppenol, D.C. (author), Vermolen, F.J. (author), Niessen, Frank B. (author), van Zuijlen, Paul P.M. (author), Vuik, Cornelis (author)A continuum hypothesis-based, biomechanical model is presented for the simulation of the collagen bundle distribution-dependent contraction and subsequent retraction of healing dermal wounds that cover a large surface area. Since wound contraction mainly takes place in the dermal layer of the skin, solely a portion of this layer is included...journal article 2016
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Koppenol, D.C. (author), Vermolen, F.J. (author), Niessen, Frank B. (author), van Zuijlen, Paul P.M. (author), Vuik, Cornelis (author)A continuum hypothesis-based model is presented for the simulation of the formation and the subsequent regression of hypertrophic scar tissue after dermal wounding. Solely the dermal layer of the skin is modeled explicitly and it is modeled as a heterogeneous, isotropic and compressible neo-Hookean solid. With respect to the constituents of the...journal article 2016
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Woudstra, L. (author), Krijnen, PAJ (author), Bogaards, SJP (author), Meinster, E (author), Emmens, RW (author), Kokhuis, TJA (author), Bollen, IAE (author), Baltzer, H (author), Baart, SMT (author), Parbhudayal, R (author), de Jong, N. (author), Helder, MN (author), Hinsbergh, V.W.M. (author), Musters, RJP (author), Kamp, O. (author), Niessen, H.W.M. (author), van Dijk, A. (author), Juffermans, LJ (author)Successful stem cell therapy after acute myocardial infarction (AMI) is hindered by lack of engraftment of sufficient stem cells at the site of injury. We designed a novel technique to overcome this problem by assembling stem cell-microbubble complexes, named 'StemBells'. StemBells were assembled through binding of dual-targeted microbubbles (...journal article 2016
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Cremers, LGM (author), de Groot, M (author), Hofman, A (author), Krestin, GP (author), van der Lugt, A. (author), Niessen, W.J. (author), Vernooij, MW (author), Arfan Ikram, M. (author)White matter microstructural integrity has been related to cognition. Yet, the potential role of specificwhite matter tracts on top of a global white matter effect remains unclear, especially when consideringspecific cognitive domains. Therefore, we determined the tract-specific effect of white matter micro-structure on global cognition and...journal article 2016
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Ikram, M.A. (author), Van der Lugt, A. (author), Niessen, W.J. (author), Koudstaal, P.J. (author), Krestin, G.P. (author), Hofman, A. (author), Bos, D. (author), Vernooij, M.W. (author)Imaging plays an essential role in research on neurological diseases in the elderly. The Rotterdam Scan Study was initiated as part of the ongoing Rotterdam Study with the aim to elucidate the causes of neurological disease by performing imaging of the brain in a prospective population-based setting. Initially, in 1995 and 1999, random...journal article 2015
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Ramkumar, A. (author), Dolz, J. (author), Kirisli, H.A. (author), Adebahr, S. (author), Schimek-Jasch, T. (author), Nestle, U. (author), Massoptier, L. (author), Varga, E. (author), Stappers, P.J. (author), Niessen, W.J. (author), Song, Y. (author)Accurate segmentation of organs at risk is an important step in radiotherapy planning. Manual segmentation being a tedious procedure and prone to inter- and intra-observer variability, there is a growing interest in automated segmentation methods. However, automatic methods frequently fail to provide satisfactory result, and post-processing...journal article 2015
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Langen, C.D. (author), White, T. (author), Ikram, M.A. (author), Vernooij, M.W. (author), Niessen, W.J. (author)Structural and functional brain connectivity are increasingly used to identify and analyze group differences in studies of brain disease. This study presents methods to analyze uni- and bi-modal brain connectivity and evaluate their ability to identify differences. Novel visualizations of significantly different connections comparing multiple...journal article 2015
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Hilal, S. (author), Xin, X. (author), Ang, S.L. (author), Tan, C.S. (author), Venketasubramanian, N. (author), Niessen, W.J. (author), Vrooman, H. (author), Wong, T.Y. (author), Chen, C. (author), Ikram, M.K. (author)Cortical thickness has been suggested to be one of the most important markers of cortical atrophy. In this study, we examined potential risk factors of cortical thickness and its association with cognition in an elderly Asian population from Singapore. This is a cross-sectional study among 572 Chinese and Malay patients from the ongoing...journal article 2015
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Klein, S. (author), Vast, E. (author), Van Soest, J. (author), Dekker, A. (author), Koek, M. (author), Niessen, W.J. (author)1st Clinical Research Informatics (CRI) Solutions Day Duesseldorf, Germany, 26-27 May 2014journal article 2015
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Alic, L. (author), Niessen, W.J. (author), Veenland, J.F. (author)BACKGROUND: Many techniques are proposed for the quantification of tumor heterogeneity as an imaging biomarker for differentiation between tumor types, tumor grading, response monitoring and outcome prediction. However, in clinical practice these methods are barely used. This study evaluates the reported performance of the described methods and...journal article 2014
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Dzyubachyk, O. (author), Khmelinskii, A. (author), Plenge, E. (author), Kok, P. (author), Snoeks, T.J. (author), Poot, D.H. (author), Löwik, C.W. (author), Botha, C.P. (author), Niessen, W.J. (author), Van der Weerd, L. (author), Meijering, E. (author), Lelieveldt, B.P.F. (author)In small animal imaging studies, when the locations of the micro-structures of interest are unknown a priori, there is a simultaneous need for full-body coverage and high resolution. In MRI, additional requirements to image contrast and acquisition time will often make it impossible to acquire such images directly. Recently, a resolution...journal article 2014
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Hoogendam, Y.Y. (author), Van der Lijn, F. (author), Vernooij, M.W. (author), Hofman, A. (author), Niessen, W.J. (author), Van der Lugt, A. (author), Arfan Ikram, M. (author), Van der Geest, J.N. (author)Introduction: In a population-based study of 1,912 community-dwelling persons of 45 years and older, we investigated the relation between age and fine motor skills using the Archimedes spiral-drawing test. Also, we studied the effect of brain volume on fine motor skills. Methods: Participants were required to trace a template of a spiral on an...journal article 2014
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Santos, E.M.M. (author), Marquering, H.A. (author), Berkhemer, O.A. (author), Van Zwam, W.H. (author), Van der Lugt, A. (author), Majoie, C.B. (author), Niessen, W.J. (author)Background and Purpose: Thrombus characterization is increasingly considered important in predicting treatment success for patients with acute ischemic stroke. The lack of intensity contrast between thrombus and surrounding tissue in CT images makes manual delineation a difficult and time consuming task. Our aim was to develop an automated...journal article 2014
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Van Engelen, A. (author), Niessen, W.J. (author), Klein, S. (author), Groen, H.C. (author), Verhagen, H.J.M. (author), Wentzel, J.J. (author), Van der Lugt, A. (author), De Bruijne, M. (author)Atherosclerotic plaque composition can indicate plaque vulnerability. We segment atherosclerotic plaque components from the carotid artery on a combination of in vivo MRI and CT-angiography (CTA) data using supervised voxelwise classification. In contrast to previous studies the ground truth for training is directly obtained from 3D registration...journal article 2014
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Bol, K. (author), Haeck, J.C. (author), Groen, H.C. (author), Niessen, W.J. (author), Bernsen, M.R. (author), De Jong, M. (author), Veenland, J.F. (author)Although efficient delivery and distribution of treatment agents over the whole tumor is essential for successful tumor treatment, the distribution of most of these agents cannot be visualized. However, with single-photon emission computed tomography (SPECT), both delivery and uptake of radiolabeled peptides can be visualized in a neuroendocrine...journal article 2013