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Van Nederveen, G.A. (author), Soons, F.A.M. (author), Suddle, S.I. (author), De Ridder, H. (author)In faculties such as Civil Engineering, design is a not a core activity. Core activities at Civil Engineering are structural engineering, structural analysis, mechanics, fluid dynamics, etc. Design education has a relatively small share in the curriculum, compared to faculties such as Industrial Design or Architecture. Against this background,...conference paper 2011
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De Ridder, H. (author)The construction industry is not sustainable. Expressed in percentages of the totals in the Netherlands and when calculated over the total lifecycle, from the early start to the processing of waste after demolition, energy consumption is more than 50%, CO2 emission is more than 50%, waste production is 35 %, road transport is 25 %, failure costs...conference paper 2011
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De Ridder, H. (author)The construction industry is not sustainable. Expressed in percentages of the totals in the Netherlands and when calculated over the total lifecycle, from the early start to the processing of waste after demolition, energy consumption is more than 50%, CO2 emission is more than 50%, waste production is 35 %, road transport is 25 %, failure costs...conference paper 2011
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De Jong, J. (author), De Ridder, J. (author), Van der Weyden, L. (author), Sun, N. (author), Van Uitert, M. (author), Berns, A. (author), Van Lohuizen, M. (author), Jonkers, J. (author), Adams, D.J. (author), Wessels, L.F.A. (author)Insertional mutagenesis is a potent forward genetic screening technique used to identify candidate cancer genes in mouse model systems. An important, yet unresolved issue in the analysis of these screens, is the identification of the genes affected by the insertions. To address this, we developed Kernel Convolved Rule Based Mapping (KC-RBM). KC...journal article 2011
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Rácz, E. (author), Kurek, D. (author), Kant, M. (author), Baerveldt, E.M. (author), Florencia, E. (author), Mourits, S. (author), De Ridder, D. (author), Laman, J.D. (author), Van der Fits, L. (author), Prens, E.P. (author)Psoriasis is characterized by hyperproliferation of keratinocytes and by infiltration of activated Th1 and Th17 cells in the (epi)dermis. By expression microarray, we previously found the GATA3 transcription factor significantly downregulated in lesional psoriatic skin. Since GATA3 serves as a key switch in both epidermal and T helper cell...journal article 2011
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De Ridder, J. (author)Advances in the field of molecular biology have resulted in a decent understanding of the causes for and mechanisms through which healthy cells can develop into cancer cells. It is, for instance, well established that cancer is caused by mutation of so-called cancer genes. That said, current knowledge on exactly which genes can function as a...doctoral thesis 2011
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Meijer, F. (author), Van den Broek, E.L. (author), Schouten, T.E. (author), Damgrave, R.G.J. (author), De Ridder, H. (author)In this paper, we explored the use of low fidelity Synthetic Environments (SE; i.e., a combination of simulation techniques) for product design. We explored the usefulness of low fidelity SE to make design problems explicit. In particular, we were interested in the influence of interactivity on user experience. For this purpose, an industrial...conference paper 2010
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- Winterbach, W. (author), Wang, H. (author), Reinders, M. (author), Van Mieghem, P. (author), De Ridder, D. (author) conference paper 2010
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Winterbach, W. (author), Wang, H. (author), Reinders, M. (author), Van Mieghem, P. (author), De Ridder, D. (author)Biological networks exhibit intriguing topological properties such as small-worldness. In this paper, we investigate whether the topology of a metabolic network is related to its robustness. We do so by perturbing a metabolic system in silico, one reaction at a time and studying the correlations between growth, as predicted by flux balance...conference paper 2010
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Nijkamp, J.F. (author), Winterbach, W. (author), Van den Broek, M. (author), Daran, J.M. (author), Reinders, M.J.T. (author), De Ridder, D. (author)De novo assembly of a eukaryotic genome with next-generation sequencing data is still a challenging task. Over the past few years several assemblers have been developed, often suitable for one specific type of sequencing data. The number of known genomes is expanding rapidly, therefore it becomes possible to use multiple reference genomes for...journal article 2010
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Verlaan, J.G. (author), De Ridder, H.A.J. (author)For two years now, Rijkswaterstaat, an agency of the Dutch Ministry of Transport, Public Works and Water Management, is required to have a financial administration, which is based on accrual accounting principles. This involves the use of a balance sheet and the equivalent of a profit and loss statement. These documents will the basis for...conference paper 2010
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Wilmer, D.W.H. (author), De Ridder, G.R. (author), Kol, A.A. (author), Harkes, D.C. (author)This bachelor report describes the creation of a fun and informative robot game for the Science Centre Delft. The project entails simulating the classic Pacman computer game using real robots. One robot, Pacman, is controlled by a player and has to fulfil certain assignments. Simultaneously the other robots, monsters, try to catch Pacman. A...report 2010
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De Ridder, J. (author), Gerrits, A. (author), Bot, J. (author), De Haan, G. (author), Reinders, M. (author), Wessels, L. (author)We propose an efficient method to infer combinatorial association logic networks from multiple genome-wide measurements from the same sample. We demonstrate our method on a genetical genomics dataset, in which we search for Boolean combinations of multiple genetic loci that associate with transcript levels. Our method provably finds the global...journal article 2010
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Taskesen, E. (author), Beekman, R. (author), De Ridder, J. (author), Wouters, B.J. (author), Peeters, J.K. (author), Touw, I.P. (author), Reinders, M.J.T. (author), Delwel, R. (author)Background: Tiling-arrays are applicable to multiple types of biological research questions. Due to its advantages (high sensitivity, resolution, unbiased), the technology is often employed in genome-wide investigations. A major challenge in the analysis of tiling-array data is to define regions-of-interest, i.e., contiguous probes with...journal article 2010
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Buzink, S.N. (author), Christie, L.S. (author), Goossens, R.H.M. (author), De Ridder, H. (author), Jakimowicz, J.J. (author)Background - The aim of this study is to investigate the influence of the presence of anatomic landmarks on the performance of angled laparoscope navigation on the SimSurgery SEP simulator. Methods - Twenty-eight experienced laparoscopic surgeons (familiar with 30º angled laparoscope, >100 basic laparoscopic procedures, >5 advanced laparoscopic...journal article 2010
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Van Egmond, R. (author), Pappas, T.N. (author), De Ridder, H. (author)In a previous study we investigated the roughness of real world textures taken from the CUReT database. We showed that people could systematically judge the subjective roughness of these textures. However, we did not determine which objective factors relate to these perceptual judgments of roughness. In the present study we take the first step...conference paper 2010
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Buzink, S.N. (author), Goossens, R.H.M. (author), Schoon, E.J. (author), De Ridder, H. (author), Jakimowicz, J.J. (author)Background - Surgical techniques that draw from multiple types of image-based procedures (IBP) are increasing, such as Natural Orifice Transluminal Endoscopic Surgery, fusing laparoscopy and flexible endoscopy. However, little is known about the relation between psychomotor skills for performing different types of IBP. For example, do basic...journal article 2010
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Meijer, F. (author), Van den Broek, E.L. (author), Schouten, T.E. (author), Damgrave, R.G.J. (author), De Ridder, H. (author)In this paper, we explored the use of low fidelity Synthetic Environments (SE; i.e., a combination of simulation techniques) for product design. We explored the usefulness of low fidelity SE to make design problems explicit. In particular, we were interested in the influence of interactivity on user experience. For this purpose, an industrial...conference paper 2010
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De Ridder, D.J. (author), McConville, M. (author), Verliefde, A.R.D. (author), Van der Aa, L.T.J. (author), Heijman, S.G.J. (author), Verberk, J.Q.J.C. (author), Rietveld, L.C. (author)The occurrence of organic micropollutants in drinking water and its sources has opened up a field of study related to monitoring concentration levels in water sources, evaluating their toxicity and estimating their removal in drinking water treatment processes. Because a large number of organic micropollutants is currently present (although in...journal article 2009
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Buzink, S.N. (author), Botden, S.M.B.I. (author), Heemskerk, J. (author), Goossens, R.H.M. (author), De Ridder, H. (author), Jakimowicz, J.J. (author)Background: It is a tacit assumption that clinically based expertise in laparoscopic tissue manipulation entails skilfulness in angled laparoscope navigation. The main objective of this study was to investigate the relation between these skills. To this end, face and construct validity had to be established for the place arrow (PA) and camera...journal article 2009