Repopulating a decellularized liver scaffold with liver-derived organoids in a perfusion-based bioreactor

Over the last decade new methods are explored in the field of tissue engineering to minimize the donor organ shortage. Engineering organs with a complex structure and large vascular network, such as the liver, remain a challenge. Luckily, the decellularization of an organ creates a scaffold that consists of the extracellular matrix (ECM) with...