- document
-
Van der Have, F. (author), Vastenhouw, B. (author), Ramakers, R.M. (author), Branderhorst, W. (author), Krah, J.O. (author), Ji, C. (author), Staelens, S.G. (author), Beekman, F.J. (author)We present a new rodent SPECT system (U-SPECT-II) that enables molecular imaging of murine organs down to resolutions of less than half a millimeter and high-resolution total-body imaging. Methods: The U-SPECT-II is based on a triangular stationary detector set-up, an XYZ stage that moves the animal during scanning, and interchangeable cylindric...journal article 2009
- document
-
Wu, C. (author), Van der Have, F. (author), Vastenhouw, B. (author), Dierckx, R.A.J.O. (author), Paans, A.M.J. (author), Beekman, F.J. (author)Purpose: In pinhole SPECT, attenuation of the photon flux on trajectories between source and pinholes affects quantitative accuracy of reconstructed images. Previously we introduced iterative methods that compensate for image degrading effects of detector and pinhole blurring, pinhole sensitivity and scatter for multi-pinhole SPECT. The aim of...journal article 2010
- document
-
Branderhorst, W. (author), Vastenhouw, B. (author), Van der Have, F. (author), Blezer, E.L.A. (author), Bleeker, W.K. (author), Beekman, F.J. (author)Purpose: Small-animal single photon emission computed tomography (SPECT) with focused multi-pinhole collimation geometries allows scanning modes in which large amounts of photons can be collected from specific volumes of interest. Here we present new tools that improve targeted imaging of specific organs and tumours, and validate the effects of...journal article 2010