Scanning dynamic light scattering optical coherence tomography for measurement of high omnidirectional flow velocities

We show scanning dynamic light scattering optical coherence tomography (OCT) omnidirectional flow measurements. Our method improves the velocity measurement limit over conventional correlation-based or phase-resolved Doppler OCT by more than a factor of 2. Our technique is applicable without a-priori knowledge of the flow geometry as our...

Fast and accurate spectral-estimation axial super-resolution optical coherence tomography

Spectral-estimation OCT (SE-OCT) is a computational method to enhance the axial resolution beyond the traditional bandwidth limit. However, it has not yet been used widely due to its high computational load, dependency on user-optimized parameters, and inaccuracy in intensity reconstruction. In this study, we implement SE-OCT using a fast...

Deep-tissue label-free quantitative optical tomography

In vivo imaging of small animals is of wide interest to the biomedical community studying biological disease and developmental processes. However, optical imaging deep in tissue is severely limited by light scattering, posing restrictions on the imaging depth, image contrast, and spatial resolution. We demonstrate optical coherence projection...

Computational 3D resolution enhancement for optical coherence tomography with a narrowband visible light source

Phase-preserving spectral estimation optical coherence tomography (SE-OCT) enables combining axial resolution improvement with computational depth of field (DOF) extension. We show that the combination of SE-OCT with interferometric synthetic aperture microscopy (ISAM) and computational adaptive optics (CAO) results in high 3D resolution over...

Multi-scale optical coherence tomography imaging and visualization of Vermeer’s Girl with a Pearl Earring

We demonstrate multi-scale multi-parameter optical coherence tomography (OCT) imaging and visualization of Johannes Vermeer’s painting Girl with a Pearl Earring. Through automated acquisition, OCT image segmentation, and 3D volume stitching we realize OCT imaging at the scale of an entire painting. This makes it possible to image, with...

Sub-diffusion flow velocimetry with number fluctuation optical coherence tomography

We have implemented number fluctuation dynamic light scattering optical coherence tomography (OCT) for measuring extremely slow, sub-diffusion flows of dilute particle suspensions using the second-order autocovariance function. Our method has a lower minimum measurable velocity than conventional correlation-based OCT or phase-resolved Doppler...