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Biodegradation-affected fatigue behavior of extrusion-based additively manufactured porous iron–manganese scaffolds

Putra, N.E. (author), Moosabeiki, Vahid (author), Leeflang, M.A. (author), Zhou, J. (author), Zadpoor, A.A. (author)

Additively manufactured (AM) biodegradable porous iron-manganese (FeMn) alloys have recently been developed as promising bone-substituting biomaterials. However, their corrosion fatigue behavior has not yet been studied. Here, we present the first study on the corrosion fatigue behavior of an extrusion-based AM porous Fe35Mn alloy under...

journal article 2024

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Deep Learning for Size-Agnostic Inverse Design of Random-Network 3D Printed Mechanical Metamaterials

Pahlavani, H. (author), Tsifoutis-Kazolis, Kostas (author), Cruz Saldivar, M. (author), Mody, Prerak (author), Zhou, J. (author), Mirzaali, Mohammad J. (author), Zadpoor, A.A. (author)

Practical applications of mechanical metamaterials often involve solving inverse problems aimed at finding microarchitectures that give rise to certain properties. The limited resolution of additive manufacturing techniques often requires solving such inverse problems for specific specimen sizes. Moreover, the candidate microarchitectures...

journal article 2023

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Extrusion-based 3D printing of biodegradable, osteogenic, paramagnetic, and porous FeMn-akermanite bone substitutes

Putra, N.E. (author), Leeflang, M.A. (author), Klimopoulou, M. (author), Dong, J. (author), Taheri, P. (author), Huan, Z. (author), Fratila-Apachitei, E.L. (author), Mol, J.M.C. (author), Chang, J. (author), Zhou, J. (author), Zadpoor, A.A. (author)

The development of biodegradable Fe-based bone implants has rapidly progressed in recent years. Most of the challenges encountered in developing such implants have been tackled individually or in combination using additive manufacturing technologies. Yet not all the challenges have been overcome. Herein, we present porous FeMn-akermanite...

journal article 2023

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Physiomimetic biocompatibility evaluation of directly printed degradable porous iron implants using various cell types

Li, Y. (author), Pavanram, P. (author), Bühring, J. (author), Rütten, S. (author), Schröder, K. U. (author), Zhou, J. (author), Pufe, T. (author), Wang, L. . (author), Zadpoor, A.A. (author), Jahr, H. (author)

Additively manufactured (AM) degradable porous metallic biomaterials offer unique opportunities for satisfying the design requirements of an ideal bone substitute. Among the currently available biodegradable metals, iron has the highest elastic modulus, meaning that it would benefit the most from porous design. Given the successful...

journal article 2023

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Biomechanical evaluation of additively manufactured patient-specific mandibular cage implants designed with a semi-automated workflow: A cadaveric and retrospective case study

van Kootwijk, A. (author), Jonker, B. P. (author), Wolvius, E. B. (author), Cruz Saldivar, M. (author), Leeflang, M.A. (author), Zhou, J. (author), Tümer, N. (author), Mirzaali, Mohammad J. (author), Zadpoor, A.A. (author)

Objective: Mandibular reconstruction using patient-specific cage implants is a promising alternative to the vascularized free flap reconstruction for nonirradiated patients with adequate soft tissues, or for patients whose clinical condition is not conducive to microsurgical reconstruction. This study aimed to assess the biomechanical...

journal article 2023

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Preventing Antibiotic-Resistant Infections: Additively Manufactured Porous Ti6Al4V Biofunctionalized with Ag and Fe Nanoparticles

Putra, N.E. (author), Leeflang, M.A. (author), Ducret, Verena (author), Patrulea, Viorica (author), Fratila-Apachitei, E.L. (author), Perron, Karl (author), Ye, Hua (author), Zhou, J. (author), Apachitei, I. (author), Zadpoor, A.A. (author)

Implant-associated infections are highly challenging to treat, particularly with the emergence of multidrug-resistant microbials. Effective preventive action is desired to be at the implant site. Surface biofunctionalization of implants through Ag-doping has demonstrated potent antibacterial results. However, it may adversely affect bone...

journal article 2022

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Extrusion-based additive manufacturing of Mg-Zn alloy scaffolds

Dong, J. (author), Tümer, N. (author), Leeflang, M.A. (author), Taheri, P. (author), Fratila-Apachitei, E.L. (author), Mol, J.M.C. (author), Zadpoor, A.A. (author), Zhou, J. (author)

Porous biodegradable Mg and its alloys are considered to have a great potential to serve as ideal bone substitutes. The recent progress in additive manufacturing (AM) has prompted its application to fabricate Mg scaffolds with geometrically ordered porous structures. Extrusion-based AM, followed by debinding and sintering, has been recently...

journal article 2022

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Poly(2-ethyl-2-oxazoline) coating of additively manufactured biodegradable porous iron

Putra, N.E. (author), Tigrine, A. (author), Aksakal, S. (author), de la Rosa, V. R. (author), Taheri, P. (author), Fratila-Apachitei, E.L. (author), Mol, J.M.C. (author), Zhou, J. (author), Zadpoor, A.A. (author)

Additively manufacturing of porous iron offers a unique opportunity to increase its biodegradation rate by taking advantage of arbitrarily complex porous structures. Nevertheless, achieving the required biodegradation profile remains challenging due to the natural passivation of iron that decrease the biodegradation rate. Moreover, the...

journal article 2022

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Deep learning for the rare-event rational design of 3D printed multi-material mechanical metamaterials

Pahlavani, H. (author), Amani, M. (author), Cruz Saldivar, M. (author), Zhou, J. (author), Mirzaali, Mohammad J. (author), Zadpoor, A.A. (author)

Emerging multi-material 3D printing techniques enables the rational design of metamaterials with not only complex geometries but also arbitrary distributions of multiple materials within those geometries, yielding unique combinations of elastic properties. However, discovering the rare designs that lead to highly unusual combinations of...

journal article 2022

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Semi-automated digital workflow to design and evaluate patient-specific mandibular reconstruction implants

van Kootwijk, A. (author), Moosabeiki, Vahid (author), Cruz Saldivar, M. (author), Pahlavani, H. (author), Leeflang, M.A. (author), Kazemivand Niar, S. (author), Tümer, N. (author), Mirzaali, Mohammad J. (author), Zhou, J. (author), Zadpoor, A.A. (author)

The reconstruction of large mandibular defects with optimal aesthetic and functional outcomes remains a major challenge for maxillofacial surgeons. The aim of this study was to design patient-specific mandibular reconstruction implants through a semi-automated digital workflow and to assess the effects of topology optimization on the...

journal article 2022

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Additive manufacturing of bioactive and biodegradable porous iron-akermanite composites for bone regeneration

Putra, N.E. (author), Borg, K. G.N. (author), Diaz Payno, P.J. (author), Leeflang, M.A. (author), Klimopoulou, M. (author), Taheri, P. (author), Mol, J.M.C. (author), Fratila-Apachitei, E.L. (author), Zhou, J. (author), Zadpoor, A.A. (author)

Advanced additive manufacturing techniques have been recently used to tackle the two fundamental challenges of biodegradable Fe-based bone-substituting materials, namely low rate of biodegradation and insufficient bioactivity. While additively manufactured porous iron has been somewhat successful in addressing the first challenge, the limited...

journal article 2022

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Extrusion-based additive manufacturing of Mg-Zn/bioceramic composite scaffolds

Dong, J. (author), Lin, P. (author), Putra, N.E. (author), Tümer, N. (author), Leeflang, M.A. (author), Huan, Z. (author), Fratila-Apachitei, E.L. (author), Chang, J. (author), Zadpoor, A.A. (author), Zhou, J. (author)

The treatment of femoral nonunion with large segmental bone defect is still challenging. Although magnesium alloys have been considered potential materials for such a treatment, their application is limited by their fast degradation. Adding bioceramic particles into magnesium to form Mg-matrix composites is a promising strategy to adjust...

journal article 2022

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Extrusion-based 3D printed biodegradable porous iron

Putra, N.E. (author), Leeflang, M.A. (author), Minneboo, M.B. (author), Taheri, P. (author), Fratila-Apachitei, E.L. (author), Mol, J.M.C. (author), Zhou, J. (author), Zadpoor, A.A. (author)

Extrusion-based 3D printing followed by debinding and sintering is a powerful approach that allows for the fabrication of porous scaffolds from materials (or material combinations) that are otherwise very challenging to process using other additive manufacturing techniques. Iron is one of the materials that have been recently shown to be...

journal article 2021

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Extrusion-based 3D printing of ex situ-alloyed highly biodegradable MRI-friendly porous iron-manganese scaffolds

Putra, N.E. (author), Leeflang, M.A. (author), Taheri, P. (author), Fratila-Apachitei, E.L. (author), Mol, J.M.C. (author), Zhou, J. (author), Zadpoor, A.A. (author)

Additively manufactured biodegradable porous iron has been only very recently demonstrated. Two major limitations of such a biomaterial are very low biodegradability and incompatibility with magnetic resonance imaging (MRI). Here, we present a novel biomaterial that resolves both of those limitations. We used extrusion-based 3D printing to...

journal article 2021

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Comparison in clinical performance of surgical guides for mandibular surgery and temporomandibular joint implants fabricated by additive manufacturing techniques

Oldhoff, M. G.E. (author), Mirzaali, Mohammad J. (author), Tümer, N. (author), Zhou, J. (author), Zadpoor, A.A. (author)

Additive manufacturing (AM) offers great design freedom that enables objects with desired unique and complex geometry and topology to be readily and cost-effectively fabricated. The overall benefits of AM are well known, such as increased material and resource efficiency, enhanced design and production flexibility, the ability to create...

journal article 2021

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Extrusion-based 3D printed magnesium scaffolds with multifunctional MgF₂and MgF₂-CaP coatings

Dong, J. (author), Tümer, N. (author), Putra, N.E. (author), Zhu, Jia-Ning (author), Li, Y. (author), Leeflang, M.A. (author), Taheri, P. (author), Fratila-Apachitei, E.L. (author), Mol, J.M.C. (author), Zadpoor, A.A. (author), Zhou, J. (author)

Additively manufactured (AM) biodegradable magnesium (Mg) scaffolds with precisely controlled and fully interconnected porous structures offer unprecedented potential as temporary bone substitutes and for bone regeneration in critical-sized bone defects. However, current attempts to apply AM techniques, mainly powder bed fusion AM, for the...

journal article 2021

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Additively manufactured functionally graded biodegradable porous zinc

Li, Y. (author), Pavanram, P. (author), Zhou, J. (author), Lietaert, K. (author), Bobbert, F.S.L. (author), Kubo, Yusuke (author), Leeflang, M.A. (author), Jahr, H. (author), Zadpoor, A.A. (author)

Topological design provides additively manufactured (AM) biodegradable porous metallic biomaterials with a unique opportunity to adjust their biodegradation behavior and mechanical properties, thereby satisfying the requirements for ideal bone substitutes. However, no information is available yet concerning the effect of topological design on...

journal article 2020

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Additively manufactured biodegradable porous zinc

Li, Y. (author), Pavanram, P. (author), Zhou, J. (author), Lietaert, K. (author), Taheri, P. (author), Li, W. (author), San, H. (author), Leeflang, M.A. (author), Mol, J.M.C. (author), Jahr, H. (author), Zadpoor, A.A. (author)

Additively manufacturing (AM) opens up the possibility for biodegradable metals to possess uniquely combined characteristics that are desired for bone substitution, including bone-mimicking mechanical properties, topologically ordered porous structure, pore interconnectivity and biodegradability. Zinc is considered to be one of the promising...

journal article 2020

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Solvent-cast 3D printing of magnesium scaffolds

Dong, J. (author), Li, Y. (author), Lin, P. (author), Leeflang, M.A. (author), van Asperen, S. (author), Yu, K. (author), Tümer, N. (author), Norder, B. (author), Zadpoor, A.A. (author), Zhou, J. (author)

Biodegradable porous magnesium (Mg) scaffolds are promising for application in the regeneration of critical-sized bone defects. Although additive manufacturing (AM) carries the promise of offering unique opportunities to fabricate porous Mg scaffolds, current attempts to apply the AM approach to fabricating Mg scaffolds have encountered some...

journal article 2020

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Corrosion fatigue behavior of additively manufactured biodegradable porous iron

Li, Y. (author), Lietaert, K. (author), Li, W. (author), Zhang, X.Y. (author), Leeflang, M.A. (author), Zhou, J. (author), Zadpoor, A.A. (author)

The corrosion fatigue behavior of additively manufactured topologically ordered porous iron based on diamond unit cells was studied for the first time to understand its response to cyclic loading in a simulated physiological environment. The material exhibited high fatigue resistance with fatigue strengths being 70% and 65% of yield stress in...

journal article 2019