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Duits, Anneli A.A. (author), Van Urk, Paul R. (author), Lehr, A. Mechteld (author), Nutzinger, Don (author), Reijnders, Maarten R.L. (author), Weinans, Harrie (author), Foppen, Wouter (author), Oner, F. Cuhmur (author), Van Gaalen, Steven M. (author), Kruyt, Moyo C. (author)Background: Lumbar interbody fusion (IF) is a common procedure to fuse the anterior spine. However, a lack of consensus on image-based fusion assessment limits the validity and comparison of IF studies. This systematic review aims to (1) report on IF assessment strategies and definitions and (2) summarize available literature on the...review 2024
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Rahmani, N. R. (author), Belluomo, R. (author), Kruyt, M. C. (author), Gawlitta, D. (author), Joosten, L. A.B. (author), Weinans, Harrie (author), Croes, M. (author)Macrophages are key regulators in bone repair and regeneration. Recent studies have shown that long-term epigenetic changes and metabolic shifts occur during specific immune training of macrophages that affect their functional state, resulting in heightened (trained) or reduced (tolerant) responses upon exposure to a second stimulus. This is...journal article 2024
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van Dijk, Bruce (author), Oliveira, Sabrina (author), Hooning van Duyvenbode, J. Fred F. (author), Nurmohamed, F. Ruben H.A. (author), Mashayekhi, Vida (author), Beltran Hernandez, Irati (author), van Strijp, Jos (author), de Vor, Lisanne (author), Aerts, Piet C. (author), Vogely, H. Charles (author), Weinans, Harrie (author), van der Wal, Bart C.H. (author)Introduction Implant infections caused by Staphylococcus aureus are responsible for high mortality and morbidity worldwide. Treatment of these infections can be difficult especially when bacterial biofilms are involved. In this study we investigate the potential of infrared photoimmunotherapy to eradicate staphylococcal infection in a mouse...journal article 2024
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van Hengel, I.A.J. (author), van Dijk, B. (author), Modaresifar, K. (author), Hooning van Duyvenbode, J. Fred F. (author), Nurmohamed, F. Ruben H.A. (author), Leeflang, M.A. (author), Fluit, A.C. (author), Fratila-Apachitei, E.L. (author), Apachitei, I. (author), Weinans, Harrie (author), Zadpoor, A.A. (author)Additively manufactured (AM) porous titanium implants may have an increased risk of implant-associated infection (IAI) due to their huge internal surfaces. However, the same surface, when biofunctionalized, can be used to prevent IAI. Here, we used a rat implant infection model to evaluate the biocompatibility and infection prevention...journal article 2023
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Cecotto, Leonardo (author), Stapels, Daphne A.C. (author), van Kessel, Kok P.M. (author), Croes, Michiel (author), Lourens, Zeldali (author), Vogely, H. Charles (author), van der Wal, Bart C.H. (author), van Strijp, Jos A.G. (author), Weinans, Harrie (author), Amin Yavari, Saber (author)Background: Despite the extensive use of silver ions or nanoparticles in research related to preventing implant-associated infections (IAI), their use in clinical practice has been debated. This is because the strong antibacterial properties of silver are counterbalanced by adverse effects on host cells. One of the reasons for this may be the...journal article 2023
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Fugazzola, Maria C. (author), Golafshan, Nasim (author), van Aken, Joris A. (author), Plomp, S. (author), De Grauw, Janny (author), van Buul, Ward (author), Hermsen, Gied (author), Weinans, Harrie (author), Castilho, Miguel (author), van Weeren, René (author), Malda, Jos (author)Summary: The objective of this study was to evaluate a non-resorbable implant for the focal repair of osteochondral defects. Enhanced adherence of repair cartilage overgrowing the implants was the secondary goal and was tested by introducing porosities on the articular surface of the implant. This study evaluated four versions of the...journal article 2023
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Arbabi, Saeed (author), Foppen, Wouter (author), Gielis, Willem Paul (author), van Stralen, Marijn (author), Jansen, Mylène (author), Arbabi, Vahid (author), de Jong, Pim A. (author), Weinans, Harrie (author), Seevinck, Peter (author)Magnetic resonance Imaging is the gold standard for assessment of soft tissues; however, X-ray-based techniques are required for evaluating bone-related pathologies. This study evaluated the performance of synthetic computed tomography (sCT), a novel MRI-based bone visualization technique, compared with CT, for the scoring of knee...journal article 2023
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Warmink, Kelly (author), Vinod, Prateeksha (author), Korthagen, Nicoline M. (author), Weinans, Harrie (author), Rios, Jaqueline L. (author)Osteoarthritis (OA) is a common and debilitating joint disorder that leads to progressive joint breakdown and loss of articular cartilage. Accompanied by a state of low-grade inflammation, its etiology extends beyond that of a wear-and-tear disease, and the immune system might have a role in its initiation and progression. Obesity, which is...review 2023
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Rayegan, H. (author), Nguyen, H. C. (author), Weinans, Harrie (author), Gielis, W. P. (author), Ahmadi Brooghani, S. Y. (author), Custers, R. J.H. (author), van Egmond, N. (author), Lindner, C. (author), Arbabi, V. (author)Objective: Herewith, we report the development of Orthopedic Digital Image Analysis (ODIA) software that is developed to obtain quantitative measurements of knee osteoarthritis (OA) radiographs automatically. Manual segmentation and measurement of OA parameters currently hamper large-cohort analyses, and therefore, automated and reproducible...journal article 2023
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Jahanmard, F. (author), Khodaei, A. (author), Flapper, Jasper (author), Dogan, O. (author), Roohi, K. (author), Taheri, P. (author), Weinans, Harrie (author), Storm, G. (author), Croes, M. (author), Mastrobattista, E. (author), Amin Yavari, S. (author)Despite being the most widely used biomaterials in orthopedic surgery, metallic implants do not induce new bone growth because they are bioinert. Surface biofunctionalization of implants with immunomodulatory mediators is a recent approach to promote osteogenic factors that facilitate bone regeneration. Liposomes (Lip) can be used as a low-cost,...journal article 2023
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Warmink, K. (author), Rios, J. L. (author), van Valkengoed, D. R. (author), Vinod, P. (author), Korthagen, N. M. (author), Weinans, Harrie (author)Introduction: Obesogenic diets aggravate osteoarthritis (OA) by inducing low-grade systemic inflammation, and diet composition may affect OA severity. Here, we investigated the effect of diet on joint damage and inflammation in an OA rat model. Methods: Wistar-Han rats (n = 24) were fed a chow, a high-fat (HF) diet, or a high-fat/high-sucrose...journal article 2023
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van Erp, Joost H.J. (author), Gielis, Willem Paul (author), Arbabi, Vahid (author), de Gast, Arthur (author), Weinans, Harrie (author), Kaas, Laurens (author), Castelein, René M. (author), Schlösser, Tom P.C. (author)Introduction: To date the aetiology of femoroacetabular impingement (FAI) is still not completely understood. There are mechanical theories that suggest symptomatic FAI is linked to sagittal pelvic morphology and spinopelvic-femoral dynamics. The aim of this study is to evaluate the relation of sagittal pelvic morphology and orientation to...journal article 2023
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Warmink, Kelly (author), Rios, Jaqueline L. (author), Varderidou-Minasian, Suzy (author), Torres-Torrillas, Marta (author), van Valkengoed, Devin R. (author), Versteeg, Sabine (author), Eijkelkamp, Niels (author), Weinans, Harrie (author), Korthagen, Nicoline M. (author), Lorenowicz, Magdalena J. (author)Background: Mesenchymal stromal/stem cells (MSCs) and MSC-derived extracellular vesicles (MSC-EVs) hold promise as a disease modifying treatment in osteoarthritis (OA). Obesity, and its associated inflammation, contribute to OA development and metabolic OA represents a specific and significant group of the OA patient population. Given their...journal article 2023
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Keikhosravani, Pardis (author), Jahanmard, Fatemah (author), Bollen, Tim (author), Nazmi, Kamran (author), Veldhuizen, Edwin J. A. (author), Gonugunta, P. (author), Ravi Anusuyadevi, P. (author), van der Wal, Bart C.H. (author), Vogely, Charles (author), Bikker, Floris J. (author), Taheri, P. (author), Weinans, Harrie (author), Yavari, Saber Amin (author)The development of antibacterial coatings is a promising approach to preventing biofilm formation and reducing the overuse of systemic antibiotics. However, widespread antibiotic use has resulted in antibiotic-resistant bacteria, limiting the efficacy of antibiotic-based coatings. Herein, an antibacterial coating is developed by layer-by-layer ...journal article 2023
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van Dijk, Bruce (author), Hooning van Duyvenbode, J. Fred F. (author), de Vor, Lisanne (author), Nurmohamed, F. Ruben H.A. (author), Lam, Marnix G.E.H. (author), Poot, Alex J. (author), Ramakers, R.M. (author), Koustoulidou, Sofia (author), Beekman, F.J. (author), Weinans, Harrie (author)Implant infections caused by Staphylococcus aureus are difficult to treat due to biofilm formation, which complicates surgical and antibiotic treatment. We introduce an alternative approach using monoclonal antibodies (mAbs) targeting S. aureus and provide evidence of the specificity and biodistribution of S.-aureus-targeting antibodies in a...journal article 2023
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Willemsen, Koen (author), Niemeyer, Menco J.S. (author), Harlianto, Netanja I. (author), Sadiqi, Said (author), Seevinck, Peter R. (author), Sakkers, Ralph J.B. (author), Weinans, Harrie (author), Van der Wal, Bart C.H. (author)BACKGROUND AND PURPOSE: The Chiari osteotomy was a regular treatment for developmental hip dysplasia before it became mostly reserved as a salvage therapy. However, the long-term survival of the Chiari osteotomy has not been systematically investigated. We investigated the survival time of the Chiari osteotomy until conversion to total hip...journal article 2022
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Warmink, Kelly (author), Siebelt, Michiel (author), Low, Philip S. (author), Riemers, Frank M. (author), Wang, Bingbing (author), Plomp, Saskia G.M. (author), Tryfonidou, Marianna A. (author), van Weeren, P. René (author), Weinans, Harrie (author), Korthagen, Nicoline M. (author)OBJECTIVE: Folate receptor beta (FR-β) has been used as a clinical marker and target in multiple inflammatory diseases, including osteoarthritis (OA) and rheumatoid arthritis (RA). However, the conditions under which FR-β+ macrophages arise remain unclear and could be affected by corticosteroids. Therefore, we studied FR-β expression in vitro...journal article 2022
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Willemsen, Koen (author), Tryfonidou, Marianna A. (author), Sakkers, Ralph J.B. (author), Castelein, René M. (author), Beukers, Martijn (author), Seevinck, Peter R. (author), Weinans, Harrie (author), van der Wal, Bart C.H. (author), Meij, Björn P. (author)The concept of a novel patient-specific 3D-printed shelf implant should be evaluated in a relevant large animal model with hip dysplasia. Therefore, three dogs with radiographic bilateral hip dysplasia and a positive subluxation test underwent unilateral acetabular augmentation with a 3D-printed dog-specific titanium implant. The...journal article 2022
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Current Evidence for Spinopelvic Characteristics Influencing Total Hip Arthroplasty Dislocation Riskvan der Gronde, B. A.T.D. (author), Schlösser, T. P.C. (author), van Erp, J. H.J. (author), Snijders, T. E. (author), Castelein, R. M. (author), Weinans, Harrie (author), de Gast, A. (author)BACKGROUND: Decreased pelvic mobility and pelvic retroversion may result from spinal degeneration and lead to changes in the orientation of the acetabular implant after total hip arthroplasty (THA). While multiple patient and surgery-related factors contribute to THA dislocations, there is increasing evidence that sagittal spinopelvic...review 2022
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de Vor, Lisanne (author), van Dijk, Bruce (author), van Kessel, Kok (author), Kavanaugh, Jeffrey S. (author), de Haas, Carla (author), Aerts, Piet C. (author), Ramakers, R.M. (author), Beekman, F.J. (author), Weinans, Harrie (author)Implant-associated Staphylococcus aureus infections are difficult to treat because of biofilm formation. Bacteria in a biofilm are often insensitive to antibiotics and host immunity. Monoclonal antibodies (mAbs) could provide an alternative approach to improve the diagnosis and potential treatment of biofilm-related infections. Here, we show...journal article 2022