- document
-
Isaakidou, A. (author), Ganjian, M. (author), van Hoften, R. (author), Cruz Saldivar, M. (author), Leeflang, M.A. (author), Groetsch, A. (author), Wątroba, M. (author), Schwiedrzik, J. (author), Mirzaali, Mohammad J. (author), Apachitei, I. (author), Fratila-Apachitei, E.L. (author), Zadpoor, A.A. (author)The currently available treatments for inner ear disorders often involve systemic drug administration, leading to suboptimal drug concentrations and side effects. Cochlear implants offer a potential solution by providing localized and sustained drug delivery to the cochlea. While the mechanical characterization of both the implants and their...journal article 2024
- document
-
Moosabeiki, Vahid (author), Yarali, E. (author), Ghalayaniesfahani, A. (author), Callens, S.J.P. (author), van Manen, T. (author), Accardo, A. (author), Ghodrat, S. (author), Bico, José (author), Habibi, Mehdi (author), Mirzaali, Mohammad J. (author), Zadpoor, A.A. (author)Emerging 4D printing techniques have enabled the realization of smart materials whose shape or properties can change with time. Two important phenomena play important roles in the 4D printing of shape memory polymeric materials. First, the anisotropic deformation of the printed filaments due to residual stresses can be harnessed to create out...journal article 2024
- document
-
4D printed shape-shifting biomaterials for tissue engineering and regenerative medicine applicationsKalogeropoulou, Maria (author), Diaz Payno, P.J. (author), Mirzaali, Mohammad J. (author), van Osch, G.J.V.M. (author), Fratila-Apachitei, E.L. (author), Zadpoor, A.A. (author)The existing 3D printing methods exhibit certain fabrication-dependent limitations for printing curved constructs that are relevant for many tissues. Four-dimensional (4D) printing is an emerging technology that is expected to revolutionize the field of tissue engineering and regenerative medicine (TERM). 4D printing is based on 3D printing,...review 2024
- document
-
Eijkel, B.I.M. (author), Apachitei, I. (author), Fratila-Apachitei, E.L. (author), Zadpoor, A.A. (author)The antibacterial biofunctionality of bone implants is essential for the prevention and treatment of implant-associated infections (IAI). In vitro co-culture models are utilized to assess this and study bacteria-host cell interactions at the implant interface, aiding our understanding of biomaterial and the immune response against IAI without...review 2024
- document
-
Yarali, E. (author), Klimopoulou, M. (author), David, M.K. (author), Boukany, P. (author), Staufer, U. (author), Fratila-Apachitei, E.L. (author), Zadpoor, A.A. (author), Accardo, A. (author), Mirzaali, Mohammad J. (author)The Poisson's ratio and elastic modulus are two parameters determining the elastic behavior of biomaterials. While the effects of elastic modulus on the cell response is widely studied, very little is known regarding the effects of the Poisson's ratio. The micro-architecture of meta-biomaterials determines not only the Poisson's ratio but...journal article 2024
- document
-
Putra, N.E. (author), Moosabeiki, Vahid (author), Leeflang, M.A. (author), Zhou, J. (author), Zadpoor, A.A. (author)Additively manufactured (AM) biodegradable porous iron-manganese (FeMn) alloys have recently been developed as promising bone-substituting biomaterials. However, their corrosion fatigue behavior has not yet been studied. Here, we present the first study on the corrosion fatigue behavior of an extrusion-based AM porous Fe35Mn alloy under...journal article 2024
- document
-
Salandova, M. (author), Leeflang, M.A. (author), Klimopoulou, M. (author), Fratila-Apachitei, E.L. (author), Apachitei, I. (author), Zadpoor, A.A. (author)This study proposes a new concept for an on-demand drug releasing device intended for integration into additively manufactured (i.e., 3D printed) orthopedic implants. The system comprises a surface with conduits connected to a subsurface reservoir used for storage and on-demand release of antimicrobial agents, covered with a cap that prevents...journal article 2024
- document
-
de Jong, P.H. (author), Salvatori, Y.S. (author), Libonati, F. (author), Mirzaali, Mohammad J. (author), Zadpoor, A.A. (author)Shape morphing is the ability of objects to adapt to different shapes and reduce stress concentrations through increased contact area. This is a common trait of natural and engineered objects and has several applications in, among others, soft robotics and orthopedic implants. Shape morphing is achieved through flexible materials or rigid...journal article 2023
- document
-
Deep Learning for Size-Agnostic Inverse Design of Random-Network 3D Printed Mechanical MetamaterialsPahlavani, H. (author), Tsifoutis-Kazolis, Kostas (author), Cruz Saldivar, M. (author), Mody, Prerak (author), Zhou, J. (author), Mirzaali, Mohammad J. (author), Zadpoor, A.A. (author)Practical applications of mechanical metamaterials often involve solving inverse problems aimed at finding microarchitectures that give rise to certain properties. The limited resolution of additive manufacturing techniques often requires solving such inverse problems for specific specimen sizes. Moreover, the candidate microarchitectures...journal article 2023
- document
-
van Hengel, I.A.J. (author), van Dijk, B. (author), Modaresifar, K. (author), Hooning van Duyvenbode, J. Fred F. (author), Nurmohamed, F. Ruben H.A. (author), Leeflang, M.A. (author), Fluit, A.C. (author), Fratila-Apachitei, E.L. (author), Apachitei, I. (author), Weinans, Harrie (author), Zadpoor, A.A. (author)Additively manufactured (AM) porous titanium implants may have an increased risk of implant-associated infection (IAI) due to their huge internal surfaces. However, the same surface, when biofunctionalized, can be used to prevent IAI. Here, we used a rat implant infection model to evaluate the biocompatibility and infection prevention...journal article 2023
- document
-
Isaakidou, A. (author), Apachitei, I. (author), Fratila-Apachitei, E.L. (author), Zadpoor, A.A. (author)Hearing loss is a highly prevalent multifactorial disorder affecting 20% of the global population. Current treatments using the systemic administration of drugs are therapeutically ineffective due to the anatomy of the cochlea and the existing blood–labyrinth barrier. Local drug delivery systems can ensure therapeutic drug concentrations locally...journal article 2023
- document
-
Garmendia Urdalleta, A. (author), van Poll, M.A. (author), Fahy, Niamh (author), Witte-Bouma, Janneke (author), van Wamel, Willem (author), Apachitei, I. (author), Zadpoor, A.A. (author), Fratila-Apachitei, E.L. (author), Farrell, Eric (author)Macrophage responses following the implantation of orthopaedic implants are essential for successful implant integration in the body, partly through intimate crosstalk with human marrow stromal cells (hMSCs) in the process of new bone formation. Additive manufacturing (AM) and plasma electrolytic oxidation (PEO) in the presence of silver...journal article 2023
- document
-
Pitta Kruize, Carlos (author), Panahkhahi, S. (author), Putra, N.E. (author), Diaz Payno, P.J. (author), van Osch, G.J.V.M. (author), Zadpoor, A.A. (author), Mirzaali, Mohammad J. (author)Bone-to-soft tissue interfaces are responsible for transferring loads between tissues with significantly dissimilar material properties. The examples of connective soft tissues are ligaments, tendons, and cartilages. Such natural tissue interfaces have unique microstructural properties and characteristics which avoid the abrupt transitions...review 2023
- document
-
Eijkenboom, J. F.A. (author), Tümer, N. (author), Schiphof, D. (author), Oei, E. H. (author), Zadpoor, A.A. (author), Bierma-Zeinstra, S. M.A. (author), van Middelkoop, M. (author)Objective: To examine the association between 3D patellar shape and 1) isolated magnetic resonance imaging (MRI)-based patellofemoral osteoarthritis (PFOA), 2) the morphological features of PFOA, and 3) the clinical symptoms of PFOA. Design: MRI data from 66 women with isolated MRI-based PFOA and 66 age- and BMI-matched healthy women were...journal article 2023
- document
-
Yang, J. (author), Chen, Xiaohong (author), Sun, Yuanxi (author), Feng, Chen (author), Yang, Zheng (author), Zadpoor, A.A. (author), Mirzaali, Mohammad J. (author), Bai, Long (author)The advent of additive manufacturing has facilitated the design and fabrication of hybrid lattice structures with multiple morphologies. These structures combine multiple distinct architectures into a single structure with an exceptional performance that far exceeds that of each constituting architecture. However, combining strut-based...journal article 2023
- document
-
Li, Yageng (author), Shi, Yixuan (author), Lu, Yuchen (author), Li, Xuan (author), Zhou, J. (author), Zadpoor, A.A. (author), Wang, Luning (author)With the advancement of additive manufacturing (AM), customized vascular stents can now be fabricated to fit the curvatures and sizes of a narrowed or blocked blood vessel, thereby reducing the possibility of thrombosis and restenosis. More importantly, AM enables the design and fabrication of complex and functional stent unit cells that...review 2023
- document
-
Putra, N.E. (author), Leeflang, M.A. (author), Klimopoulou, M. (author), Dong, J. (author), Taheri, P. (author), Huan, Z. (author), Fratila-Apachitei, E.L. (author), Mol, J.M.C. (author), Chang, J. (author), Zhou, J. (author), Zadpoor, A.A. (author)The development of biodegradable Fe-based bone implants has rapidly progressed in recent years. Most of the challenges encountered in developing such implants have been tackled individually or in combination using additive manufacturing technologies. Yet not all the challenges have been overcome. Herein, we present porous FeMn-akermanite...journal article 2023
- document
-
Cruz Saldivar, M. (author), Veeger, Robin Petrus Elias (author), Tay, E.T.W.S. (author), Fenu, M. (author), Klimopoulou, M. (author), van Osch, G.J.V.M. (author), Fratila-Apachitei, E.L. (author), Doubrovski, E.L. (author), Mirzaali, Mohammad J. (author), Zadpoor, A.A. (author)Living organisms use functional gradients (FGs) to interface hard and soft materials (e.g., bone and tendon), a strategy with engineering potential. Past attempts involving hard (or soft) phase ratio variation have led to mechanical property inaccuracies because of microscale-material macroscale-property nonlinearity. This study examines 3D...journal article 2023
- document
-
Cruz Saldivar, M. (author), Tay, E.T.W.S. (author), Isaakidou, A. (author), Moosabeiki, Vahid (author), Fratila-Apachitei, E.L. (author), Doubrovski, E.L. (author), Mirzaali, Mohammad J. (author), Zadpoor, A.A. (author)Durable interfacing of hard and soft materials is a major design challenge caused by the ensuing stress concentrations. In nature, soft-hard interfaces exhibit remarkable mechanical performance, with failures rarely happening at the interface. Here, we mimic the strategies observed in nature to design efficient soft-hard interfaces. We base...journal article 2023
- document
-
Yarali, E. (author), Zadpoor, A.A. (author), Staufer, U. (author), Accardo, A. (author), Mirzaali, Mohammad J. (author)Mechanical and morphological design parameters, such as stiffness or porosity, play important roles in creating orthopedic implants and bone substitutes. However, we have only a limited understanding of how the microarchitecture of porous scaffolds contributes to bone regeneration. Meta-biomaterials are increasingly used to precisely engineer...review 2023