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Rasman, Brandon G. (author), van der Zalm, P.C. (author), Forbes, P.A. (author)Background: While standing upright, the brain must accurately accommodate for delays between sensory feedback and self-generated motor commands. Natural aging may limit adaptation to sensorimotor delays due to age-related decline in sensory acuity, neuromuscular capacity and cognitive function. This study examined balance learning in young and...journal article 2023
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Unperceived motor actions of the balance system interfere with the causal attribution of self-motionTisserand, Romain (author), Rasman, Brandon G. (author), Omerovic, Nina (author), Peters, Ryan M. (author), Forbes, P.A. (author), Blouin, Jean Sébastien (author)The instability of human bipedalism demands that the brain accurately senses balancing self-motion and determines whether movements originate from self-generated actions or external disturbances. Here, we challenge the longstanding notion that this process relies on a single representation of the body and world to accurately perceive postural...journal article 2022
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Happee, R. (author), de Bruijn, E. (author), Forbes, Patrick (author), van Drunen, P. (author), van Dieën, Jaap H. (author), van der Helm, F.C.T. (author)The human head-neck system requires continuous muscular stabilization in the presence of gravity and trunk motion. This chapter presents experimental and modeling efforts, applying mechanical perturbations to seated subjects, evaluating trunk and head motion, to investigate postural stabilization.<br/><br/>A detailed multisegment neck model has...book chapter 2019
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Kwan, Annie (author), Forbes, P.A. (author), Mitchell, Diana E. (author), Blouin, Jean Sébastien (author), Cullen, Kathleen E. (author)Galvanic vestibular stimulation (GVS) uses the external application of electrical current to selectively target the vestibular system in humans. Despite its recent popularity for the assessment/treatment of clinical conditions, exactly how this non-invasive tool activates the vestibular system remains an open question. Here we directly...journal article 2019
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Arntz, Anne I. (author), Van Der Putte, Daphne A.M. (author), Jonker, Z.D. (author), Hauwert, Christopher M. (author), Frens, Maarten A. (author), Forbes, P.A. (author)Vestibular signals, which encode head movement in space as well as orientation relative to gravity, contribute to the ongoing muscle activity required to stand. The strength of this vestibular contribution changes with the presence and quality of sensory cues of balance. Here we investigate whether the vestibular drive for standing balance...journal article 2019
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Forbes, P.A. (author), Fice, Jason B. (author), Siegmund, Gunter P. (author), Blouin, Jean Sébastien (author)Neck muscle activity evoked by vestibular stimuli is a clinical measure for evaluating the function of the vestibular apparatus. Cervical vestibular-evoked myogenic potentials (cVEMP) are most commonly measured in the sternocleidomastoid muscle (and more recently the splenius capitis muscle) in response to air-conducted sound, bone-conducted...journal article 2018
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Rasman, Brandon G. (author), Forbes, P.A. (author), Tisserand, Romain (author), Blouin, Jean Sébastien (author)Standing balance relies on the integration of multiple sensory inputs to generate the motor commands required to stand. Mechanical and sensory perturbations elicit compensatory postural responses that are interpreted as a window into the sensorimotor processing involved in balance control. Popular methods involve imposed external...review 2018
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Puylaert, Carl A.J. (author), Schüffler, Peter J. (author), Naziroglu, R.E. (author), Tielbeek, Jeroen A.W. (author), Li, Z. (author), Makanyanga, Jesica C. (author), Tutein Nolthenius, Charlotte J. (author), Nio, C. Yung (author), Pendsé, Douglas A. (author), Menys, Alex (author), Ponsioen, Cyriel Y. (author), Atkinson, David (author), Forbes, Alastair (author), Buhmann, Joachim M. (author), Fuchs, Thomas J. (author), Hatzakis, Haralambos (author), van Vliet, L.J. (author), Stoker, Jaap (author), Taylor, Stuart A. (author), Vos, F.M. (author)Rationale and Objectives: The objective of this study was to develop and validate a predictive magnetic resonance imaging (MRI) activity score for ileocolonic Crohn disease activity based on both subjective and semiautomatic MRI features. Materials and Methods: An MRI activity score (the “virtual gastrointestinal tract [VIGOR]” score) was...journal article 2018
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Forbes, P.A. (author), de Bruijn, E. (author), Nijmeijer, SWR (author), Koelman, JHTM (author), van der Helm, F.C.T. (author), Schouten, A.C. (author), Tijssen, MAJ (author), Happee, R. (author)Background Effective sensorimotor integration is essential to modulate (adapt) neck stabilization strategies in response to varying tasks and disturbances. This study evaluates the hypothesis that relative to healthy controls cervical dystonia patients have an impaired ability to modulate afferent feedback for neck stabilization with changes...journal article 2017
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Happee, R. (author), de Bruijn, E. (author), Forbes, P.A. (author), van der Helm, F.C.T. (author)The human head-neck system requires continuous stabilization in the presence of gravity and trunk motion. We investigated contributions of the vestibulocollic reflex (VCR), the cervicocollic reflex (CCR), and neck muscle co-contraction to head-in-space and head-on-trunk stabilization, and investigated modulation of the stabilization strategy...journal article 2017
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de Bruijn, E. (author), Nijmeijer, SWR (author), Forbes, P.A. (author), Koelman, JHTM (author), van der Helm, F.C.T. (author), Tijssen, MAJ (author), Happee, R. (author)Objective<br/>To identify effects of a deviant motor drive in the autospectral power of dystonic muscles during voluntary contraction in cervical dystonia patients.<br/>Methods<br/>Submaximal (20%) isometric head-neck tasks were performed with the head fixed, measuring surface EMG of the sternocleidomastoid, splenius capitis and semispinalis...journal article 2017
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Nijmeijer, S.W.R. (author), de Bruijn, E. (author), Verhagen, R. (author), Forbes, P.A. (author), Kamphuis, D.J. (author), Happee, R. (author), Tijssen, M.A.J. (author), Koelman, J.H.T.M. (author)Botulinum toxin (BoNT) injections in the dystonic muscles is the preferred treatment for Cervical Dystonia (CD), but the proper identification of the dystonic muscles remains a challenge. Previous studies showed decreased 8–14 Hz autospectral power in the electromyography (EMG) of splenius muscles in CD patients. Cumulative distribution...journal article 2017
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Kriegel, Franziska (author), Ermann, Niklas (author), Forbes, R.J.G. (author), Dulin, D. (author), Dekker, N.H. (author), Lipfert, J. (author)The mechanical properties of DNA fundamentally constrain and enable the storage and transmission of genetic information and its use in DNA nanotechnology. Many properties of DNA depend on the ionic environment due to its highly charged backbone. In particular, both theoretical analyses and direct singlemolecule experiments have shown its...journal article 2017
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Forbes, P.A. (author), Vlutters, M (author), Dakin, CJ (author), van der Kooij, H. (author), Blouin, JS (author), Schouten, A.C. (author)During walking, the vestibular influence on locomotor activity is phase-dependent and modulated in both limbs with changes in velocity. It is unclear, however, whether this bilateral modulation is due to a coordinated mechanism between both limbs or instead through limb-specific processes that remain masked by the symmetric nature of locomotion....journal article 2017
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Gasperini, F. (author), Forbes, J. M. (author), Doornbos, E.N. (author), Bruinsma, S. L. (author)Meridional winds in the thermosphere are key to understanding latitudinal coupling and thermosphere-ionosphere coupling, and yet global measurements of this wind component are scarce. In this work, neutral and electron densities measured by the Challenging Minisatellite Payload (CHAMP) satellite at solar low and geomagnetically quiet...journal article 2016
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Gasperini, F. (author), Forbes, J.M. (author), Doornbos, E.N. (author), Bruinsma, S.L. (author)Vertical coupling between the lower and middle thermosphere due to the eastward propagating diurnal tide with zonal wave number 3 (DE3) and the 3.5?day ultra-fast Kelvin Wave (UFKW) is investigated using Thermosphere, Ionosphere, Mesosphere, Energetics and Dynamics-Sounding of the Atmosphere using Broadband Emission Radiometry (TIMED-SABER)...journal article 2015
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Häusler, K. (author), Hagan, M.E. (author), Forbes, J.M. (author), Zhang, X. (author), Doornbos, E. (author), Bruinsma, S. (author), Lu, G. (author)In this paper, we provide insights into limitations imposed by current satellite-based strategies to delineate tidal variability in the thermosphere, as well as the ability of a state-of-the-art model to replicate thermospheric tidal determinations. Toward this end, we conducted a year-long thermosphere-ionosphere-mesosphere-electrodynamics...journal article 2015
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Forbes, P.A. (author), Siegmund, G.P. (author), Schouten, A.C. (author), Blouin, J.S. (author)The vestibular system is crucial for postural control; however there are considerable differences in the task dependence and frequency response of vestibular reflexes in appendicular and axial muscles. For example, vestibular reflexes are only evoked in appendicular muscles when vestibular information is relevant to postural control, while in...journal article 2015
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Zhang, J.T. (author), Forbes, J.M. (author), Zhang, C.H. (author), Doornbos, E.N. (author), Bruinsma, S.L. (author)As the utilization of low-Earth orbit increases, so does the need for improved ephemeris predictions and thus more accurate density models. In this paper we quantify the density variability of the thermosphere attributable to the lunar gravitational tide, a potentially predictable component of variability not included in any operational density...journal article 2014
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Häusler, K. (author), Hagan, M.E. (author), Baumgaertner, A.J.G. (author), Maute, A. (author), Lu, G. (author), Doornbos, E.N. (author), Bruinsma, S. (author), Forbes, J.M. (author), Gasperini, F. (author)We report on a new source of tidal variability in the National Center for Atmospheric Research thermosphere-ionosphere-mesosphere-electrodynamics general circulation model (TIME-GCM). Lower boundary forcing of the TIME-GCM for a simulation of November–December 2009 based on 3-hourly Modern-Era Retrospective Analysis for Research and Application ...journal article 2014
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