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Computer-Aided Diagnosis and Prediction in Brain Disorders

Venkatraghavan, Vikram (author), Voort, Sebastian R.van der (author), Bos, Daniel (author), Smits, M. (author), Barkhof, Frederik (author), Niessen, W.J. (author), Klein, Stefan (author), Bron, Esther E. (author)

Computer-aided methods have shown added value for diagnosing and predicting brain disorders and can thus support decision making in clinical care and treatment planning. This chapter will provide insight into the type of methods, their working, their input data –such as cognitive tests, imaging, and genetic data– and the types of output they...

book chapter 2023

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Cross-cohort generalizability of deep and conventional machine learning for MRI-based diagnosis and prediction of Alzheimer's disease

Bron, Esther E. (author), Klein, Stefan (author), Papma, Janne M. (author), Jiskoot, Lize C. (author), Venkatraghavan, Vikram (author), Linders, Jara (author), Aalten, Pauline (author), De Deyn, Peter Paul (author), Niessen, W.J. (author)

This work validates the generalizability of MRI-based classification of Alzheimer's disease (AD) patients and controls (CN) to an external data set and to the task of prediction of conversion to AD in individuals with mild cognitive impairment (MCI). We used a conventional support vector machine (SVM) and a deep convolutional neural network ...

journal article 2021

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Progression along data-driven disease timelines is predictive of Alzheimer's disease in a population-based cohort

Venkatraghavan, Vikram (author), Vinke, Elisabeth J. (author), Bron, Esther E. (author), Niessen, W.J. (author), Arfan Ikram, M. (author), Klein, S. (author), Vernooij, Meike W. (author)

Data-driven disease progression models have provided important insight into the timeline of brain changes in AD phenotypes. However, their utility in predicting the progression of pre-symptomatic AD in a population-based setting has not yet been investigated. In this study, we investigated if the disease timelines constructed in a case...

journal article 2021

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Longitudinal diffusion MRI analysis using Segis-Net: A single-step deep-learning framework for simultaneous segmentation and registration

Li, Bo (author), Niessen, W.J. (author), Klein, Stefan (author), de Groot, Marius (author), Ikram, M. Arfan (author), Vernooij, Meike W. (author), Bron, Esther E. (author)

This work presents a single-step deep-learning framework for longitudinal image analysis, coined Segis-Net. To optimally exploit information available in longitudinal data, this method concurrently learns a multi-class segmentation and nonlinear registration. Segmentation and registration are modeled using a convolutional neural network and...

journal article 2021

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Differences Between MR Brain Region Segmentation Methods: Impact on Single-Subject Analysis

Huizinga, W. (author), Poot, D.H.J. (author), Vinke, E. J. (author), Wenzel, F. (author), Bron, E. E. (author), Ikram, M. A. (author), Niessen, W.J. (author), Vernooij, M.N.A. (author), Klein, S. (author)

For the segmentation of magnetic resonance brain images into anatomical regions, numerous fully automated methods have been proposed and compared to reference segmentations obtained manually. However, systematic differences might exist between the resulting segmentations, depending on the segmentation method and underlying brain atlas. This...

journal article 2021

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Analyzing the effect of APOE on Alzheimer's disease progression using an event-based model for stratified populations

Venkatraghavan, Vikram (author), Klein, S. (author), Fani, Lana (author), Ham, Leontine S. (author), Vrooman, Henri (author), Ikram, M. Kamran (author), Niessen, W.J. (author), Bron, Esther E. (author)

Alzheimer's disease (AD) is the most common form of dementia and is phenotypically heterogeneous. APOE is a triallelic gene which correlates with phenotypic heterogeneity in AD. In this work, we determined the effect of APOE alleles on the disease progression timeline of AD using a discriminative event-based model (DEBM). Since DEBM is a data...

journal article 2020

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Cerebral blood flow and cognitive functioning in patients with disorders along the heart–brain axis: Cerebral blood flow and the heart–brain axis

Leeuwis, Anna E. (author), Hooghiemstra, Astrid M. (author), Bron, Esther E. (author), Kuipers, Sanne (author), Oudeman, Eline A. (author), Kalay, Tugba (author), Niessen, W.J. (author)

Introduction: We examined the role of hemodynamic dysfunction in cognition by relating cerebral blood flow (CBF), measured with arterial spin labeling (ASL), to cognitive functioning, in patients with heart failure (HF), carotid occlusive disease (COD), and patients with cognitive complaints and vascular brain injury on magnetic resonance...

journal article 2020

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Disease progression timeline estimation for Alzheimer's disease using discriminative event based modeling

Venkatraghavan, Vikram (author), Bron, Esther E. (author), Niessen, W.J. (author), Klein, S. (author)

Alzheimer's Disease (AD) is characterized by a cascade of biomarkers becoming abnormal, the pathophysiology of which is very complex and largely unknown. Event-based modeling (EBM) is a data-driven technique to estimate the sequence in which biomarkers for a disease become abnormal based on cross-sectional data. It can help in understanding...

journal article 2019

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H₂ formation on interstellar dust grains: The viewpoints of theory, experiments, models and observations

Wakelam, Valentine (author), Bron, Emeric (author), Cazaux, S.M. (author), Dulieu, Francois (author), Gry, Cécile (author), Guillard, Pierre (author), Habart, Emilie (author), Hornekær, Liv (author), Morisset, Sabine (author), Nyman, Gunnar (author), Pirronello, Valerio (author), Price, Stephen D. (author), Valdivia, Valeska (author), Vidali, Gianfranco (author), Watanabe, Naoki (author)

Molecular hydrogen is the most abundant molecule in the universe. It is the first one to form and survive photo-dissociation in tenuous environments. Its formation involves catalytic reactions on the surface of interstellar grains. The micro-physics of the formation process has been investigated intensively in the last 20 years, in parallel...

review 2017

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The Missing Link in the Pathophysiology of Vascular Cognitive Impairment: Design of the Heart-Brain Study

Hooghiemstra, Astrid M. (author), Bertens, Anne Suzanne (author), Leeuwis, Anna E. (author), Bron, Esther E. (author), Bots, Michiel L. (author), Brunner-La Rocca, Hans Peter (author), De Craen, Anton J M (author), van der Geest, Rob J. (author), Greving, Jacoba P. (author), Kappelle, L. Jaap (author), Niessen, W.J. (author), van Oostenbrugge, Robert J. (author), van Osch, Matthias J P (author), de Roos, Albert (author), van Rossum, Albert C. (author), Biessels, Geert Jan (author), van Buchem, Mark A. (author), Daemen, Mat J A P (author), van der Flier, Wiesje M. (author)

Background: Hemodynamic balance in the heart-brain axis is increasingly recognized as a crucial factor in maintaining functional and structural integrity of the brain and thereby cognitive functioning. Patients with heart failure (HF), carotid occlusive disease (COD), and vascular cognitive impairment (VCI) present themselves with complaints...

journal article 2017

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Design of the ExCersion-VCI study: The effect of aerobic exercise on cerebral perfusion in patients with vascular cognitive impairment

Leeuwis, Anna E. (author), Hooghiemstra, Astrid M. (author), Amier, Raquel (author), Ferro, Doeschka A. (author), Franken, Leonie (author), Nijveldt, Robin (author), Kuijer, Joost P A (author), Bronzwaer, Anne Sophie G T (author), van Lieshout, Johannes J. (author), Rietberg, Marc B. (author), Veerbeek, Janne M. (author), Huijsmans, Rosalie J. (author), Backx, Frank J G (author), Teunissen, Charlotte E. (author), Bron, Esther E. (author), Barkhof, Frederik (author), Prins, Niels D. (author), Shahzad, Rahil (author), Niessen, W.J. (author), de Roos, Albert (author), van Osch, Matthias J P (author), van Rossum, Albert C. (author), Biessels, Geert J. (author), van der Flier, Wiesje M. (author)

There is evidence for a beneficial effect of aerobic exercise on cognition, but underlying mechanisms are unclear. In this study, we test the hypothesis that aerobic exercise increases cerebral blood flow (CBF) in patients with vascular cognitive impairment (VCI). This study is a multicenter single-blind randomized controlled trial among 80...

journal article 2017

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Multiparametric computer-aided differential diagnosis of Alzheimer’s disease and frontotemporal dementia using structural and advanced MRI

Bron, Esther E. (author), Smits, Marion (author), Papma, Janne M. (author), Steketee, Rebecca M E (author), Meijboom, Rozanna (author), De Groot, Marius (author), van Swieten, John C. (author), Niessen, W.J. (author), Klein, S. (author)

Objectives: To investigate the added diagnostic value of arterial spin labelling (ASL) and diffusion tensor imaging (DTI) to structural MRI for computer-aided classification of Alzheimer's disease (AD), frontotemporal dementia (FTD), and controls. Methods: This retrospective study used MRI data from 24 early-onset AD and 33 early-onset FTD...

journal article 2016

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Modeling the brain morphology distribution in the general aging population

Huizinga, W. (author), Poot, D.H.J. (author), Roshchupkin, G. (author), Bron, E. E. (author), Ikram, M. A. (author), Vernooij, M. W. (author), Rueckert, D. (author), Niessen, W.J. (author), Klein, S. (author)

Both normal aging and neurodegenerative diseases such as Alzheimer's disease cause morphological changes of the brain. To better distinguish between normal and abnormal cases, it is necessary to model changes in brain morphology owing to normal aging. To this end, we developed a method for analyzing and visualizing these changes for the...

conference paper 2016

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Fast parallel image registration on CPU and GPU for diagnostic classification of Alzheimer's disease

Shamonin, D.P. (author), Bron, E.E. (author), Lelieveldt, B.P.F. (author), Smits, M. (author), Klein, S. (author), Staring, M. (author)

Nonrigid image registration is an important, but time-consuming task in medical image analysis. In typical neuroimaging studies, multiple image registrations are performed, i.e., for atlas-based segmentation or template construction. Faster image registration routines would therefore be beneficial. In this paper we explore acceleration of the...

journal article 2014

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Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) shows no change in cartilage structural composition after viscosupplementation in patients with early-stage knee osteoarthritis

Van Tiel, J. (author), Reijman, M. (author), Bos, P.K. (author), Hermans, J. (author), Van Buul, G.M. (author), Bron, E.E. (author), Klein, S. (author), Verhaar, J.A.N. (author), Krestin, G.P. (author), Bierma-Zeinstra, S.M.A. (author), Weinans, H. (author), Kotek, G. (author), Oei, E.H.G. (author)

journal article 2013

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Transcriptome-Based Characterization of Interactions between Saccharomyces cerevisiae and Lactobacillus delbrueckii subsp. bulgaricus in Lactose-Grown Chemostat Cocultures

Mendes, F. (author), Sieuwerts, S. (author), De Hulster, E. (author), Almering, M.J. (author), Luttik, M.A. (author), Pronk, J.T. (author), Smid, E.J. (author), Bron, P.A. (author), Daran-Lapujade, P. (author)

Mixed populations of Saccharomyces cerevisiae yeasts and lactic acid bacteria occur in many dairy, food, and beverage fermentations, but knowledge about their interactions is incomplete. In the present study, interactions between Saccharomyces cerevisiae and Lactobacillus delbrueckii subsp. bulgaricus, two microorganisms that co-occur in kefir...

journal article 2013

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Short- and Long-Term Adaptation to Ethanol Stress and Its Cross-Protective Consequences in Lactobacillus plantarum

Van Bokhorst-van de Veen, H. (author), Abee, T. (author), Tempelaars, M. (author), Bron, P.A. (author), Kleerebezem, M. (author), Marco, M.L. (author)

This paper describes the molecular responses of Lactobacillus plantarum WCFS1 toward ethanol exposure. Global transcriptome profiling using DNA microarrays demonstrated adaptation of the microorganism to the presence of 8% ethanol over short (10-min and 30-min) and long (24-h) time intervals. A total of 57 genes were differentially expressed at...

journal article 2011

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Mathematical model of enlarged four-barge push tow combination based on PMM experiments

Quadvlieg, F.H.H.A. (author), Bron, I. (author), Loeff, G.B. (author)

report 2004

document

Cabine-ontwerp voor een mobiele havenkraan

Bron, D.A. (author)

master thesis 1995

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Testmethode voor de vermoeiingstestmachine bij Dunlop-Enerka

Bron, D.A. (author)

report 1994