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Varini, M. (author), Koleva, D.A. (author), Denkova, A.G. (author), Mol, J.M.C. (author), Terryn, H. (author), Van Breugel, K. (author)Polymeric nano-materials utilization in reinforced concrete, aiming to deal with steel corrosion was developed in previous works. Promising results were obtained with PEObPS nano-formations, both in terms of enhanced bulk matrix properties and improved steel corrosion resistance. Recent research has been focusing on a cheaper and commercially...conference paper 2013
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Koleva, D.A. (author), Denkova, A.G. (author), Hu, J. (author), van Breugel, K. (author)The influence of Pluronic P123 (PEO20-PPO20-PEO70) micelles (of 10 nm size) on the corrosion behaviour of low carbon steel in cement extract (CE) was studied using electrochemical impedance spectroscopy (EIS) and potentio-dynamic polarisation (PDP). Additionally, mercury intrusion porosimetry (MIP) was emplo ed to derive the impact of admixed...conference paper 2012
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Varini, M. (author), Koleva, D.A. (author), Denkova, A.G. (author), Mol, J.M.C. (author), Terryn, H. (author), Van Breugel, K. (author)Polymeric nano-materials utilization in reinforced concrete, aiming to deal with steel corrosion was developed in previous works. Promising results were obtained with PEO–b–PS nano-formations, both in terms of enhanced bulk matrix properties and improved steel corrosion resistance. Recent research has been focusing on a cheaper and commercially...conference paper 2013
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Denkova, A.G. (author)The purpose of this thesis is to obtain a better understanding of the formation mechanism of mesoporous silica materials, such as SBA-15 that use block copolymers as templating agents. Despite the fact that these materials are now extensively synthesized, the fundamental role of the different synthesis variables has not been determined on the...doctoral thesis 2009
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De Kruijff, R.M. (author), Wolterbeek, H.T. (author), Denkova, A.G. (author)This review presents an overview of the successes and challenges currently faced in alpha radionuclide therapy. Alpha particles have an advantage in killing tumour cells as compared to beta or gamma radiation due to their short penetration depth and high linear energy transfer (LET). Touching briefly on the clinical successes of radionuclides...journal article 2015
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Yao, T. (author), Gasparini, A. (author), Denkova, A.G. (author), Warman, J.M. (author)The radiation-induced polymerization and fluorescence intensity of a radio-fluorogenic medium consisting of tertiary-butyl acrylate (TBA) with ca 100 ppm maleimido-pyrene (MPy) display a super-linear dependence on dose and a close to inverse square root dependence on dose rate over the range from 2 to 30 Gy/min. In contrast with the fluorescence...journal article 2015
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Laan, A.C. (author), Santini, C. (author), Jennings, L. (author), De Jong, M. (author), Bernsen, M.R. (author), Denkova, A.G. (author)Background Single photon emission computed tomography (SPECT) is an indispensable tool in the determination of the in vivo fate of polymeric micelles. However, for this purpose, the micelles need to be radiolabeled, and almost all radiolabeling procedures published to date involve the conjugation of a chelating agent to the constituting polymer,...journal article 2016
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Bhardwaj, R. (author), Wolterbeek, H.T. (author), Denkova, A.G. (author), Serra Crespo, P. (author)Background In this work, a lutetium-177 (177Lu) production method based on the separation of nuclear isomers, 177mLu & 177Lu, is reported. The 177mLu-177Lu separation is performed by combining the use of DOTA & DOTA-labelled peptide (DOTATATE) and liquid-liquid extraction. Methods The 177mLu cations were complexed with DOTA &...journal article 2019
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Bhardwaj, R. (author), Wolterbeek, H.T. (author), Denkova, A.G. (author), Serra Crespo, P. (author)A solid phase extraction based <sup>177m</sup>Lu-<sup>177</sup>Lu separation method has been investigated for its feasibility to be used in the radionuclide generator. The use of 2,2′,2”-(10-(2,6-dioxotetrahydro-2H-pyran-3-yl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic acid, (DOTAGA-anhydride) allowed grafting of DOTA (1,4,7,10...journal article 2020
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Kouwenberg, J.J.M. (author), Kremers, G. J. (author), Slotman, J. A. (author), Wolterbeek, H.T. (author), Houtsmuller, A.B. (author), Denkova, A.G. (author), bos, A.J.J. (author)Structured illumination microscopy (SIM) for the imaging of alpha particle tracks in fluorescent nuclear track detectors (FNTD) was evaluated and compared to confocal laser scanning microscopy (CLSM). FNTDs were irradiated with an external alpha source and imaged using both methodologies. SIM imaging resulted in improved resolution, without...journal article 2018
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Yao, T. (author), Gasparini, A. (author), de Haas, M.P. (author), Luthjens, L.H. (author), Denkova, A.G. (author), Warman, J.M. (author)In this work a 40 mm cube of an optically clear, radio-fluorogenic gel composed of partially-polymerized tertiary-butyl acrylate and maleimido-pyrene (~0.01%) is irradiated with orthogonally-crossed, 10 mm square and round, 200 kVp x-ray beams. A thin sheet of UV light is produced between two parallel plates with 2 mm slits illuminated by...journal article 2017
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Breve, T. (author), Filius, M. (author), Weerdenburg, S. (author), van der Griend, Stefan J. (author), Groeneveld, T. (author), Denkova, A.G. (author), Eelkema, R. (author)Stimuli-responsive soft materials enable controlled release of loaded drug molecules and biomolecules. Controlled release of potent chemotherapeutic or immunotherapeutic agents is crucial to reduce unwanted side effects. In an effort to develop controlled release strategies that can be triggered by using Cerenkov luminescence, we have...journal article 2021
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Men, Y. (author), Breve, T. (author), Liu, H. (author), Denkova, A.G. (author), Eelkema, R. (author)We present a new light cleavable polymer containing o-nitrobenzene thioacetal groups in the main chain. By conjugation to a PEG block, we synthesized block copolymers capable of forming nanoparticles in aqueous solution. We studied drug encapsulation and release using the model drug Nile Red. Irradiation with UV-A light (365 nm) leads to...journal article 2021
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Breve, T. (author), Liu, H. (author), Denkova, A.G. (author), Eelkema, R. (author)Gamma radiation triggered secondary crosslinking of dextran hydrogels leads to macroscopic hydrogel contraction. The authors use stable polymer hydrogels, prepared through azide-alkyne crosslinking, containing surplus alkyne groups. γ-irradiation of these gels leads to more alkyne crosslinking, enabling controlled increase of crosslink...journal article 2021
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Tack, N. (author), Wamelink, G. W.W. (author), Denkova, A.G. (author), Schouwenburg, M. (author), Hilhorst, H. (author), Wolterbeek, H.T. (author), Goedhart, P. W. (author)The Martian surface is constantly exposed to a high dose of cosmic radiation consisting of highly energetic particles and multiple types of ionizing radiation. The dose can increase temporarily by a factor of 50 through the occurrence of highly energetic solar flares. This may affect crop growth in greenhouses on the Martian surface possibly...journal article 2021
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Ma, C. (author), Vasileiadis, A. (author), Wolterbeek, H.T. (author), Denkova, A.G. (author), Serra Crespo, P. (author)The potential of the metal–organic framework UiO-66 and its functionalized derivatives for their utilization in the <sup>99</sup>Mo/<sup>99m</sup>Tc generator was assessed. Molybdenum adsorption experiments, structure characterization, molecular simulations and column experiments with molybdenum-99 were carried out. The results showed that...journal article 2021
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Ma, C. (author), Liu, H. (author), Wolterbeek, H.T. (author), Denkova, A.G. (author), Serra Crespo, P. (author)Four different MOFs were exposed to γrays by a cobalt-60 source reaching a maximum dose of 5 MGy. The results showed that the MIL-100 (Cr) and MIL-100 (Fe) did not exhibit obvious structural damage, suggesting their excellent radiation stability. MIL-101 (Cr) showed good radiation stability up to 4 MGy, but its structure started degrading...journal article 2022
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Ma, C. (author), Wolterbeek, H.T. (author), Denkova, A.G. (author), Serra Crespo, P. (author)The cerium-based metal–organic framework UiO-66 (Ce) was examined as a potential adsorbent for the <sup>99</sup>Mo/<sup>99m</sup>Tc generator. The results showed that the adsorbent had an outstanding adsorption performance, reaching up to 475 mg/g adsorption capacity at pH 3. An adsorption mechanism was proposed, where the adsorption was...journal article 2022
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van Oossanen, R. (author), Godart, Jeremy (author), Brown, J.M.C. (author), Maier, A. (author), Pignol, Jean-Philippe (author), Denkova, A.G. (author), Djanashvili, K. (author), van Rhoon, G.C. (author)Background: Treatment of early-stage breast cancer currently includes surgical removal of the tumor and (partial) breast irradiation of the tumor site performed at fractionated dose. Although highly effective, this treatment is exhaustive for both patient and clinic. In this study, the theoretical potential of an alternative treatment combining...journal article 2022
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de Kruijff, R.M. (author), van der Meer, A.J.G.M. (author), Windmeijer, C.A.A. (author), Kouwenberg, J.J.M. (author), Morgenstern, A. (author), Bruchertseifer, F. (author), Sminia, P. (author), Denkova, A.G. (author)Alpha emitters have great potential in targeted tumour therapy, especially in destroying micrometastases, due to their high linear energy transfer (LET). To prevent toxicity caused by recoiled daughter atoms in healthy tissue, alpha emitters like <sup>225</sup>Ac can be encapsulated in polymeric nanocarriers (polymersomes), which are capable...journal article 2018