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Warmink, Kelly (author), Siebelt, Michiel (author), Low, Philip S. (author), Riemers, Frank M. (author), Wang, Bingbing (author), Plomp, Saskia G.M. (author), Tryfonidou, Marianna A. (author), van Weeren, P. René (author), Weinans, Harrie (author), Korthagen, Nicoline M. (author)OBJECTIVE: Folate receptor beta (FR-β) has been used as a clinical marker and target in multiple inflammatory diseases, including osteoarthritis (OA) and rheumatoid arthritis (RA). However, the conditions under which FR-β+ macrophages arise remain unclear and could be affected by corticosteroids. Therefore, we studied FR-β expression in vitro...journal article 2022
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Aleksinskaya, Marina A. (author), Monge, Matthieu (author), Siebelt, Michiel (author), Slot, Edith M. (author), Koekkoek, Karin M. (author), de Bruin, Ruben G. (author), Massy, Ziad A. (author), Weinans, Harrie (author), Rabelink, Ton J. (author), Fibbe, Willem E. (author), Jan van Zonneveld, Anton (author), van Pel, Melissa (author)In chronic kidney disease (CKD), endothelial injury, is associated with disease progression and an increased risk for cardiovascular complications. Circulating cells with vascular reparative functions are hematopoietic and also reduced in CKD. To explore the mechanistic basis behind these observations, we have investigated hematopoietic stem...journal article 2018
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- Siebelt, M (author), Korthagen, NM (author), Wei, W. (author), Groen, H (author), Bastiaansen-Jenniskens, YM (author), Müller, C (author), Waarsing, JH (author), de Jong, M (author), Weinans, Harrie (author) journal article 2015
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Siebelt, M. (author), Groen, H.C. (author), Koelewijn, S.J. (author), De Blois, E. (author), Sandker, M. (author), Waarsing, J.H. (author), Müller, C. (author), Van Osch, G.J.V.M. (author), De Jong, M. (author), Weinans, H.H. (author)Introduction Articular cartilage needs sulfated-glycosaminoglycans (sGAGs) to withstand high pressures while mechanically loaded. Chondrocyte sGAG synthesis is regulated by exposure to compressive forces. Moderate physical exercise is known to improve cartilage sGAG content and might protect against osteoarthritis (OA). This study investigated...journal article 2014
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Van der Stok, J. (author), Wang, H. (author), Yavari, S.A. (author), Siebelt, M. (author), Sandker, M. (author), Waarsing, J.H. (author), Verhaar, J.A.N. (author), Jahr, H. (author), Zadpoor, A.A. (author), Leeuwenburgh, S.C.G. (author), Weinans, H. (author)Porous titanium scaffolds are a promising class of biomaterials for grafting large bone defects, because titanium provides sufficient mechanical support, whereas its porous structure allows bone ingrowth resulting in good osseointegration. To reinforce porous titanium scaffolds with biological cues that enhance and continue bone regeneration,...journal article 2013