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Liefaard, Marte C. (author), Moore, Kat S. (author), Mulder, Lennart (author), van den Broek, Daan (author), Wesseling, Jelle (author), Sonke, Gabe S. (author), Wessels, L.F.A. (author), Rookus, Matti (author), Lips, Esther H. (author)In this article the data availability statement was incorrectly given. “EGAS0000100682” should have been “EGAS00001006821”. The correct statement as follows. The datasets generated during and/or analysed during the current study are deposited at the European Genome-phenome Archive (EGA) under the accession numbers EGAS00001006821 and...journal article 2023
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Liefaard, Marte C. (author), Moore, Kat S. (author), Mulder, Lennart (author), van den Broek, Daan (author), Wesseling, Jelle (author), Sonke, Gabe S. (author), Wessels, L.F.A. (author), Rookus, Matti (author), Lips, Esther H. (author)Background: Studies have shown that blood platelets contain tumour-specific mRNA profiles tumour-educated platelets (TEPs). Here, we aim to train a TEP-based breast cancer detection classifier. Methods: Platelet mRNA was sequenced from 266 women with stage I–IV breast cancer and 212 female controls from 6 hospitals. A particle swarm optimised...journal article 2023
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Lips, Silvia (author), Tsap, Valentyna (author), Bharosa, Nitesh (author), Krimmer, Robert (author), Tammet, Tanel (author), Draheim, Dirk (author)In the management of national electronic identity (eID) infrastructure, cooperation between public and private parties becomes more and more important, as the mutual dependencies between the provision of e-services and the provision of the national public key infrastructure (PKI) continuously increases. Yet, it is not clear which key factors...journal article 2023
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Lips, Esther H. (author), Kumar, Tapsi (author), Megalios, Anargyros (author), Visser, Lindy L. (author), Sheinman, Michael (author), Fortunato, Angelo (author), Shah, Vandna (author), Hoogstraat, Marlous (author), Wessels, L.F.A. (author)Ductal carcinoma in situ (DCIS) is the most common form of preinvasive breast cancer and, despite treatment, a small fraction (5–10%) of DCIS patients develop subsequent invasive disease. A fundamental biologic question is whether the invasive disease arises from tumor cells in the initial DCIS or represents new unrelated disease. To address...journal article 2022
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Hoogstraat, Marlous (author), Lips, Esther H. (author), Mayayo-Peralta, Isabel (author), Mulder, Lennart (author), Kristel, Petra (author), van der Heijden, Ingrid (author), Annunziato, Stefano (author), van Seijen, Maartje (author), Wessels, L.F.A. (author)When locally advanced breast cancer is treated with neoadjuvant chemotherapy, the recurrence risk is significantly higher if no complete pathologic response is achieved. Identification of the underlying resistance mechanisms is essential to select treatments with maximal efficacy and minimal toxicity. Here we employed gene expression profiles...journal article 2022
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Band, Ruben (author), Lips, Maarten (author), Prawira, Julivius (author), van Schagen, Jurgen (author), Tulling, Simon (author), Zhang, Ying (author), Benaiss, Aicha A. (author), van der Ham, Ineke J.M. (author), Bueno Perez, M.R. (author), Bidarra, Rafael (author)In recent years, the use of Augmented and Virtual Reality (ARNR) has taken a larger role within training and education of various fields, but not every individual experiences the benefits that AR and VR technology are thought to provide. The perspective taking skill of an individual may be a good indicator of the effectiveness that AR and VR...conference paper 2022
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Yousefi, Sahar (author), Sokooti, Hessam (author), Elmahdy, Mohamed S. (author), Lips, Irene M. (author), Shalmani, Mohammad T.Manzuri (author), Zinkstok, Roel T. (author), Dankers, Frank J.W.M. (author), Staring, M. (author)Manual or automatic delineation of the esophageal tumor in CT images is known to be very challenging. This is due to the low contrast between the tumor and adjacent tissues, the anatomical variation of the esophagus, as well as the occasional presence of foreign bodies (e.g. feeding tubes). Physicians therefore usually exploit additional...journal article 2021
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Schouten, Philip C. (author), Richters, Lisa (author), Vis, Daniel J. (author), Kommoss, Stefan (author), Kluin, Roelof J.C. (author), Lips, Esther H. (author), Schmidt, Sandra (author), Nederlof, Petra M. (author), Wessels, L.F.A. (author)Purpose: Previously, we developed breast cancer BRCA1-like and BRCA2-like copy-number profile shrunken centroid classifiers predictive for mutation status and response to therapy, targeting homologous recombination deficiency (HRD). Therefore, we investigated BRCA1- and BRCA2-like classification in ovarian cancer, aiming to acquire...journal article 2021
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Bharosa, Nitesh (author), Lips, Silvia (author), Draheim, Dirk (author)Countries are struggling to develop data exchange infrastructures needed to reap the benefits of e-government. Understanding the development of infrastructures can only be achieved by combining insights from institutional, technical and process perspectives. This paper contributes by analysing data exchange infrastructures in the Netherlands...conference paper 2020
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Lips, Silvia (author), Bharosa, Nitesh (author), Draheim, Dirk (author)Solid eID (electronic identification) infrastructures form the backbone of today’s digital transformation. In June 2014, the European Commission adopted the eIDAS regulation (electronic identification and trust services for electronic transactions in the internal market) as a major initiative towards EU-wide eID interoperability; which...conference paper 2020
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Valdesueiro, David (author), Hettinga, Hans (author), Drijfhout, Jan Pieter (author), Lips, Priscilla (author), Meesters, G.M.H. (author), Kreutzer, M.T. (author), van Ommen, J.R. (author)In this work, we report a method to change the surface finish of a standard polyester-based powder coating paint, from gloss to matt, by depositing ultrathin films of Al<sub>2</sub>O<sub>3</sub> on the powder coating particles. The coating experiments were performed in a fluidized bed reactor at 1 bar and 27 °C, using a gas-phase coating...journal article 2017
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Kersten, Kelly (author), Coffelt, Seth B. (author), Hoogstraat, Marlous (author), Verstegen, Niels J.M. (author), Vrijland, Kim (author), Ciampricotti, Metamia (author), Doornebal, Chris W. (author), Hau, Cheei-Sing (author), Wellenstein, Max D. (author), Salvagno, Camilla (author), Doshi, Parul (author), Lips, Esther H. (author), Wessels, L.F.A. (author), de Visser, Karin E. (author)Patients with primary solid malignancies frequently exhibit signs of systemic inflammation. Notably, elevated levels of neutrophils and their associated soluble mediators are regularly observed in cancer patients, and correlate with reduced survival and increased metastasis formation. Recently, we demonstrated a mechanistic link between...journal article 2017
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Lips, Esther H. (author), Michaut, Magali (author), Hoogstraat, Marlous (author), Mulder, Lennart (author), Besselink, Nicole J.M. (author), Koudijs, Marco J. (author), Cuppen, Edwin (author), Voest, Emile E. (author), Bernards, Rene (author), Nederlof, Petra M. (author), Wesseling, Jelle (author), Rodenhuis, Sjoerd (author), Wessels, L.F.A. (author)Introduction<br/>In triple negative breast cancers (TNBC) the initial response to chemotherapy is often favorable, but relapse and chemotherapy resistance frequently occur in advanced disease. Hence there is an urgent need for targeted treatments in this breast cancer subtype. In the current study we deep sequenced DNA of tumors prior to...journal article 2015
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Melskens, J. (author), Schnegg, A. (author), Baldansuren, A. (author), Lips, K. (author), Plokker, M.P. (author), Eijt, S.W.H. (author), Schut, H. (author), Fischer, M. (author), Zeman, M. (author), Smets, A.H.M. (author)The structural and electrical properties of metastable defects in various types of hydrogenated amorphous silicon have been studied using a powerful combination of continuous wave electron-paramagnetic resonance spectroscopy, electron spin echo (ESE) decay measurements, and Doppler broadening positron annihilation spectroscopy. The observed...journal article 2015
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Schouten, P.C. (author), Grigoriadis, A. (author), Kuilman, T. (author), Mirza, H. (author), Watkins, J.A. (author), Cooke, S.A. (author), Van Dyk, E. (author), Severson, T.M. (author), Rueda, O.M. (author), Hoogstraat, M. (author), Verhagen, C. (author), Natrajan, R. (author), Chin, S.F. (author), Lips, E.H. (author), Kruizinga, J. (author), Velds, A. (author), Nieuwland, M. (author), Kerkhoven, R.M. (author), Krijgsman, O. (author), Vens, C. (author), Peeper, D. (author), Nederlof, P.M. (author), Caldas, C. (author), Tutt, A.N. (author), Wessels, L.F.A. (author), Linn, S.C. (author)Breast cancers with BRCA1 germline mutation have a characteristic DNA copy number (CN) pattern. We developed a test that assigns CN profiles to be ‘BRCA1-like’ or ‘non-BRCA1-like’, which refers to resembling a BRCA1-mutated tumor or resembling a tumor without a BRCA1 mutation, respectively. Approximately one third of the BRCA1-like breast...journal article 2015
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Vollebergh, M.A. (author), Lips, E.H. (author), Nederlof, P.M. (author), Wessels, L.F.A. (author), Wesseling, J. (author), Van de Vijver, M.J. (author), De vries, E.G.E. (author), Van Tinteren, H. (author), Jonkers, J. (author), Hauptman, M. (author), Rodenhuis, S. (author), Linn, S.C. (author)Introduction: BRCA-mutated breast cancer cells lack the DNA-repair mechanism homologous recombination that is required for error-free DNA double-strand break (DSB) repair. Homologous recombination deficiency (HRD) may cause hypersensitivity to DNA DSB-inducing agents, such as bifunctional alkylating agents and platinum salts. HRD can be caused...journal article 2014
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De Ronde, J.J. (author), Bonder, M.J. (author), Lips, E.H. (author), Rodenhuis, S. (author), Wessels, L.F.A. (author)Introduction: Despite continuous efforts, not a single predictor of breast cancer chemotherapy resistance has made it into the clinic yet. However, it has become clear in recent years that breast cancer is a collection of molecularly distinct diseases. With ever increasing amounts of breast cancer data becoming available, we set out to study if...journal article 2014
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Arens, B. (author), Van der Meulen, F. (author), Witter, J.V. (author), Heil, G.W. (author), Lips, M. (author)Het rapport verschaft een onderbouwing voor de beleidsanalyse voor wat betreft de invloed op duinfuncties van effecten die het gevolg zijn van kustachteruitgang. In het rapport ligt de nadruk op de functie natuur. Op grond van beoordelingscriteria zijn natuurklassen opgesteld die in de beleidsanalyse zijn gehanteerd bij de berekening van...report 1989
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- Lips, K.W. (author) report 1972
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Lips, J.A. (author)Document(en) uit de collectie Chemische Procestechnologiereport 1962