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Identification and systematic annotation of tissue-specific differentially methylated regions using the Illumina 450k array

Slieker, R.C. (author), Bos, S.D. (author), Goeman, J.J. (author), Bovee, J.V.M.G. (author), Talens, R.P. (author), Van der Breggen, R. (author), Suchiman, H.E.D. (author), Lameijer, E.W. (author), Putter, H. (author), Van dern Akker, E.B. (author), Zhang, Y. (author), Jukema, J.W. (author), Slagboom, P.E. (author), Meulenbelt, I. (author), Heijmans, B.T. (author)

Background: DNA methylation has been recognized as a key mechanism in cell differentiation. Various studies have compared tissues to characterize epigenetically regulated genomic regions, but due to differences in study design and focus there still is no consensus as to the annotation of genomic regions predominantly involved in tissue-specific...

journal article 2013

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Underlying molecular mechanisms of DIO2 susceptibility in symptomatic osteoarthritis

Bomer, N. (author), Den Hollander, W.T.H.F. (author), Ramos, Y.F.M. (author), Bos, S.D. (author), Van der Breggen, R. (author), Lakenberg, N. (author), Pepers, B.A. (author), Van Eeden, A.E. (author), Darvishan, A. (author), Tobi, E.W. (author), Duijnisveld, B.J. (author), Van den Akker, E.B. (author), Heijmans, B.T. (author), Van Roon-Mom, W.M.C. (author), Verbeek, F.J. (author), Osch, G.J.V.M. (author), Nelissen, R.G.H.H. (author), Slagboom, P.E. (author), Meulenbelt, I. (author)

Objectives: To investigate how the genetic susceptibility gene DIO2 confers risk to osteoarthritis (OA) onset in humans and to explore whether counteracting the deleterious effect could contribute to novel therapeutic approaches. Methods: Epigenetically regulated expression of DIO2 was explored by assessing methylation of positional CpG...

journal article 2015

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IL7R gene expression network associates with human healthy ageing

Passtoors, W.M. (author), Van den Akker, E.B. (author), Deelen, J. (author), Maier, A.B. (author), Van der Breggen, R. (author), Jansen, R. (author), Trompet, S. (author), Van Heemst, D. (author), Derhovanessian, E. (author), Pawelec, G. (author), Van Ommen, G.J.B. (author), Slagboom, P.E. (author), Beekman, M. (author)

journal article 2015

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Meta-analysis on blood transcriptomic studies identifies consistently coexpressed protein–protein interaction modules as robust markers of human aging

Van den Akker, E.B. (author), Passtoors, W.M. (author), Jansen, R. (author), Van Zwet, E.W. (author), Goeman, J.J. (author), Hulsman, M. (author), Emilsson, V. (author), Perola, M. (author), Willemsen, G. (author), Penninx, B.W.J.H. (author), Heijmans, B.T. (author), Maier, A.B. (author), Boomsma, D.I. (author), Kok, J.N. (author), Slagboom, P.E. (author), Reinders, M.J.T. (author), Beekman, M. (author)

The bodily decline that occurs with advancing age strongly impacts on the prospects for future health and life expectancy. Despite the profound role of age in disease etiology, knowledge about the molecular mechanisms driving the process of aging in humans is limited. Here, we used an integrative network-based approach for combining multiple...

journal article 2013

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Technical Report: A Comprehensive Comparison between Different Quantification Versions of Nightingale Health’s 1H-NMR Metabolomics Platform

Bizzarri, D. (author), Reinders, M.J.T. (author), Beekman, Marian (author), Slagboom, P. Eline (author), van den Akker, E.B. (author)

1H-NMR metabolomics data is increasingly used to track health and disease. Nightingale Health, a major supplier of 1H-NMR metabolomics, has recently updated the quantification strategy to further align with clinical standards. Such updates, however, might influence backward replicability, particularly affecting studies with repeated measures....

journal article 2023

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1H-NMR metabolomics-based surrogates to impute common clinical risk factors and endpoints

Bizzarri, D. (author), Reinders, M.J.T. (author), Beekman, M. (author), Slagboom, P. E. (author), van den Akker, E.B. (author)

Background: Missing or incomplete phenotypic information can severely deteriorate the statistical power in epidemiological studies. High-throughput quantification of small-molecules in bio-samples, i.e. ‘metabolomics’, is steadily gaining popularity, as it is highly informative for various phenotypical characteristics. Here we aim to leverage...

journal article 2022

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Timing of objectively-collected physical activity in relation to body weight and metabolic health in sedentary older people: a cross-sectional and prospective analysis

Albalak, Gali (author), Stijntjes, M. (author), Wijsman, Carolien A. (author), Slagboom, P. Eline (author), van der Ouderaa, Frans J. (author), Mooijaart, Simon P. (author), van Heemst, Diana (author), Noordam, Raymond (author)

Background: Little is known about the impact of timing as opposed to frequency and intensity of daily physical activity on metabolic health. Therefore, we assessed the association between accelerometery-based daily timing of physical activity and measures of metabolic health in sedentary older people. Methods: Hourly mean physical activity...

journal article 2022

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Epigenetic and Metabolomic Biomarkers for Biological Age: A Comparative Analysis of Mortality and Frailty Risk

Kuiper, L.M. (author), Polinder-Bos, Harmke A. (author), Bizzarri, D. (author), Vojinovic, Dina (author), Vallerga, Costanza L. (author), Reinders, M.J.T. (author), Slagboom, P. Eline (author), van den Akker, E.B. (author)

Biological age captures a person's age-related risk of unfavorable outcomes using biophysiological information. Multivariate biological age measures include frailty scores and molecular biomarkers. These measures are often studied in isolation, but here we present a large-scale study comparing them. In 2 prospective cohorts (n = 3 222), we...

journal article 2023

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Cerebral microbleeds and lacunar infarcts are associated with walking speed independent of cognitive performance in middle-aged to older adults

Stijntjes, M. (author), De Craen, Anton J M (author), Van Der Grond, Jeroen (author), Meskers, Carel G M (author), Slagboom, P. Eline (author), Maier, Andrea B. (author)

Background: The positive relationship between cognitive and physical performance has been widely established. The influence of brain structure on both domains has been shown as well. Objective: We studied whether the relationship between brain structure and physical performance is independent of cognitive performance. Methods: This was a...

journal article 2016

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MiMIR: R-shiny application to infer risk factors and endpoints from Nightingale Health's ¹H-NMR metabolomics data

Bizzarri, D. (author), Reinders, M.J.T. (author), Beekman, M. (author), Slagboom, P. E. (author), van den Akker, E.B. (author)

Motivation: 1H-NMR metabolomics is rapidly becoming a standard resource in large epidemiological studies to acquire metabolic profiles in large numbers of samples in a relatively low-priced and standardized manner. Concomitantly, metabolomics-based models are increasingly developed that capture disease risk or clinical risk factors. These...

journal article 2022

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Metabolomic predictors of phenotypic traits can replace and complement measured clinical variables in population-scale expression profiling studies

Niehues, Anna (author), Bizzarri, Daniele (author), Reinders, M.J.T. (author), Slagboom, P. Eline (author), van Gool, Alain J. (author), van den Akker, E.B. (author), 't Hoen, Peter A.C. (author)

Population-scale expression profiling studies can provide valuable insights into biological and disease-underlying mechanisms. The availability of phenotypic traits is essential for studying clinical effects. Therefore, missing, incomplete, or inaccurate phenotypic information can make analyses challenging and prevent RNA-seq or other omics...

journal article 2022

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Broad phenotype of cysteine-altering NOTCH3 variants in UK Biobank: CADASIL to nonpenetrance

Rutten, Julie W. (author), Hack, Remco J. (author), Duering, Marco (author), Gravesteijn, Gido (author), Dauwerse, Johannes G. (author), Overzier, Maurice (author), van den Akker, E.B. (author), Slagboom, Eline (author), Holstege, H. (author)

To determine the small vessel disease spectrum associated with cysteine-altering NOTCH3 variants in community-dwelling individuals by analyzing the clinical and neuroimaging features of UK Biobank participants harboring such variants. The exome and genome sequencing datasets of the UK Biobank (n = 50,000) and cohorts of cognitively healthy...

journal article 2020

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RNA sequencing data integration reveals an miRNA interactome of osteoarthritis cartilage

Coutinho de Almeida, Rodrigo (author), Ramos, Yolande F.M. (author), Mahfouz, A.M.E.T.A. (author), den Hollander, Wouter (author), Lakenberg, Nico (author), Houtman, Evelyn (author), van Hoolwerff, Marcella (author), Suchiman, H. Eka D. (author), Rodriguez-Ruiz, Alejandro (author), Slagboom, P. Eline (author), Mei, Hailiang (author), Kielbasa, Szymon M. (author), Nelissen, R.G.H.H. (author), Reinders, M.J.T. (author), Meulenbelt, Ingrid (author)

Objective To uncover the microRNA (miRNA) interactome of the osteoarthritis (OA) pathophysiological process in the cartilage.<br/>Methods We performed RNA sequencing in 130 samples (n=35 and n=30 pairs for messenger RNA (mRNA) and miRNA, respectively) on macroscopically preserved and lesioned OA cartilage from the same patient and performed...

journal article 2018

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The AccelerAge framework: a new statistical approach to predict biological age based on time-to-event data

Sluiskes, Marije (author), Goeman, Jelle (author), Beekman, Marian (author), Slagboom, Eline (author), van den Akker, E.B. (author), Putter, H. (author), Rodríguez-Girondo, Mar (author)

Aging is a multifaceted and intricate physiological process characterized by a gradual decline in functional capacity, leading to increased susceptibility to diseases and mortality. While chronological age serves as a strong risk factor for age-related health conditions, considerable heterogeneity exists in the aging trajectories of...

journal article 2024

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AGV Control - The key to successful transport systems with automated guided vehicles in the production environment (summary)

Slagboom, S.M. (author)

master thesis 2009

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Symmetrical response of a tire running over short obstacles

Slagboom, T.G. (author)

master thesis 1990

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AGV Control - The key to successful transport systems with automated guided vehicles in the production environment

Slagboom, S.M. (author)