- document
-
van Oossanen, R. (author), Maier, A. (author), Godart, Jérémy (author), Pignol, Jean Philippe (author), Denkova, A.G. (author), van Rhoon, Gerard C. (author), Djanashvili, K. (author)Objective: To investigate the potential of hybrid Pd/Fe-oxide magnetic nanoparticles designed for thermo-brachytherapy of breast cancer, considering their specific loss power (SLP) and clinical constraints in the applied magnetic field. Methods: Hybrid nanoparticles consisting of palladium-core and iron oxide shell of increasing thickness,...journal article 2024
- document
-
Wang, R. (author), Liu, Huanhuan (author), Antal, Bas (author), Wolterbeek, H.T. (author), Denkova, A.G. (author)The relatively high linear energy transfer of Auger electrons, which can cause clustered DNA damage and hence efficient cell death, makes Auger emitters excellent candidates for attacking metastasized tumors. Moreover, gammas or positrons are usually emitted along with the Auger electrons, providing the possibility of theragnostic...journal article 2024
- document
-
Androulakis, Ioannis (author), Ferrero, Riccardo (author), van Oossanen, R. (author), Manzin, Alessandra (author), Denkova, A.G. (author), Djanashvili, K. (author), Nadar, R.A. (author), van Rhoon, G.C. (author)While hyperthermia has been shown to induce a variety of cytotoxic and sensitizing effects on cancer tissues, the thermal dose–effect relationship is still not well quantified, and it is still unclear how it can be optimally combined with other treatment modalities. Additionally, it is speculated that different methods of applying...journal article 2023
- document
-
Handula, M. (author), Beekman, Savanne (author), Konijnenberg, Mark (author), Stuurman, Debra (author), de Ridder, Corrina (author), Bruchertseifer, Frank (author), Morgenstern, Alfred (author), Denkova, A.G. (author), de Blois, Erik (author), Seimbille, Y. (author)Background: The [<sup>177</sup>Lu]Lu-DOTA-TATE mediated peptide receptor radionuclide therapy (PRRT) of neuroendocrine tumors (NETs) is sometimes leading to treatment resistance and disease recurrence. An interesting alternative could be the somatostatin antagonist, [<sup>177</sup>Lu]Lu-DOTA-JR11, that demonstrated better biodistribution...journal article 2023
- document
-
Trapp, S. (author), Lammers, Tom (author), Engudar, Gokce (author), Hoehr, Cornelia (author), Denkova, A.G. (author), Paulssen, E. (author), de Kruijff, R.M. (author)Background: The radionuclide Ga-68 is commonly used in nuclear medicine, specifically in positron emission tomography (PET). Recently, the interest in producing Ga-68 by cyclotron irradiation of [<sup>68</sup>Zn]Zn nitrate liquid targets is increasing. However, current purification methods of Ga-68 from the target solution consist of multi...journal article 2023
- document
-
Ma, C. (author), Wolterbeek, H.T. (author), Denkova, A.G. (author), Serra Crespo, P. (author)Two porphyrinic metal-organic frameworks (PCN-222 and PCN-224) were prepared and their potential as molybdenum adsorbents for the <sup>99</sup>Mo/<sup>99m</sup>Tc generator was explored. The molybdenum adsorption properties of the two adsorbents, including adsorption kinetics and equilibrium isotherms, were evaluated at different molybdenum...journal article 2023
- document
-
Liu, H. (author), Nadar, R.A. (author), Fauzia, R.P. (author), Laan, A.C. (author), Wang, R. (author), van Cooten, Quenteijn (author), Carroll, E.C.M. (author), Eelkema, R. (author), Denkova, A.G. (author)Combination of therapies is a common strategy in cancer treatment. Such combined therapies only have merit provided that there is superior therapeutic outcome with fewer side effects, compared to single therapies. Here, this work explores the possibility to combine chemotherapy with radionuclide therapy using polymeric micelles as a delivery...journal article 2023
- document
-
Ma, C. (author), Liu, H. (author), Wolterbeek, H.T. (author), Denkova, A.G. (author), Serra Crespo, P. (author)Four different MOFs were exposed to γrays by a cobalt-60 source reaching a maximum dose of 5 MGy. The results showed that the MIL-100 (Cr) and MIL-100 (Fe) did not exhibit obvious structural damage, suggesting their excellent radiation stability. MIL-101 (Cr) showed good radiation stability up to 4 MGy, but its structure started degrading...journal article 2022
- document
-
Ma, C. (author), Wolterbeek, H.T. (author), Denkova, A.G. (author), Serra Crespo, P. (author)The cerium-based metal–organic framework UiO-66 (Ce) was examined as a potential adsorbent for the <sup>99</sup>Mo/<sup>99m</sup>Tc generator. The results showed that the adsorbent had an outstanding adsorption performance, reaching up to 475 mg/g adsorption capacity at pH 3. An adsorption mechanism was proposed, where the adsorption was...journal article 2022
- document
-
van Oossanen, R. (author), Godart, Jeremy (author), Brown, J.M.C. (author), Maier, A. (author), Pignol, Jean-Philippe (author), Denkova, A.G. (author), Djanashvili, K. (author), van Rhoon, G.C. (author)Background: Treatment of early-stage breast cancer currently includes surgical removal of the tumor and (partial) breast irradiation of the tumor site performed at fractionated dose. Although highly effective, this treatment is exhaustive for both patient and clinic. In this study, the theoretical potential of an alternative treatment combining...journal article 2022
- document
-
Liu, H. (author), de Kruijff, R.M. (author), Laan, A.C. (author), Beekman, F.J. (author), van den Heuvel, E.J. (author), Ramakers, R.M. (author), Eelkema, R. (author), Denkova, A.G. (author)A variety of polymer micelles are designed for the delivery of chemotherapeutic drugs to tumors. Although the promise of these nanocarriers is very high, in the clinic the effectivity is rather limited. Determining the in vivo fate of the micelles can greatly help to improve this treatment. Here, a simple and fast chelator-free method for...journal article 2022
- document
-
Piergentili, I. (author), Bouwmans, Pepijn R. (author), Reinalda, L. (author), Lewis, R.W. (author), Klemm, Benjamin (author), Liu, H. (author), de Kruijff, R.M. (author), Denkova, A.G. (author), Eelkema, R. (author)In certain tumor and diseased tissues, reactive oxygen species (ROS), such as H<sub>2</sub>O<sub>2</sub>, are produced in higher concentrations than in healthy cells. Drug delivery and release systems that respond selectively to the presence of ROS, while maintaining their stability in “healthy” biological conditions, have great potential as...journal article 2022
- document
-
Toyohara, Jun (author), Al-Qahtani, Mohammed (author), Huang, Ya Yao (author), Cazzola, Emiliano (author), Todde, Sergio (author), Furumoto, Shozo (author), Mikolajczak, Renata (author), Denkova, A.G. (author), Seimbille, Y. (author)Background: The Editorial Board of EJNMMI Radiopharmacy and Chemistry releases a biannual highlight commentary to update the readership on trends in the field of radiopharmaceutical development. Main Body: This commentary of highlights has resulted in 21 different topics selected by each coauthoring Editorial Board member addressing a variety...review 2022
- document
-
Maier, A. (author), van Oossanen, R. (author), van Rhoon, G.C. (author), Pignol, J.P.M. (author), Dugulan, A.I. (author), Denkova, A.G. (author), Djanashvili, K. (author)Heterostructured magnetic nanoparticles show great potential for numerous applications in biomedicine due to their ability to express multiple functionalities in a single structure. Magnetic properties are generally determined by the morphological characteristics of nanoparticles, such as the size/shape, and composition of the nanocrystals....journal article 2022
- document
-
Wang, R. (author), Ponsard, Bernard (author), Wolterbeek, H.T. (author), Denkova, A.G. (author)Background: Radionuclide therapy (RNT) has become a very important treatment modality for cancer nowadays. Comparing with other cancer treatment options, sufficient efficacy could be achieved in RNT with lower toxicity. β<sup>−</sup> emitters are frequently used in RNT due to the long tissue penetration depth of the β<sup>−</sup> particles....journal article 2022
- document
-
Breve, T. (author), Filius, M. (author), Weerdenburg, S. (author), van der Griend, Stefan J. (author), Groeneveld, T. (author), Denkova, A.G. (author), Eelkema, R. (author)Stimuli-responsive soft materials enable controlled release of loaded drug molecules and biomolecules. Controlled release of potent chemotherapeutic or immunotherapeutic agents is crucial to reduce unwanted side effects. In an effort to develop controlled release strategies that can be triggered by using Cerenkov luminescence, we have...journal article 2021
- document
-
Men, Y. (author), Breve, T. (author), Liu, H. (author), Denkova, A.G. (author), Eelkema, R. (author)We present a new light cleavable polymer containing o-nitrobenzene thioacetal groups in the main chain. By conjugation to a PEG block, we synthesized block copolymers capable of forming nanoparticles in aqueous solution. We studied drug encapsulation and release using the model drug Nile Red. Irradiation with UV-A light (365 nm) leads to...journal article 2021
- document
-
Breve, T. (author), Liu, H. (author), Denkova, A.G. (author), Eelkema, R. (author)Gamma radiation triggered secondary crosslinking of dextran hydrogels leads to macroscopic hydrogel contraction. The authors use stable polymer hydrogels, prepared through azide-alkyne crosslinking, containing surplus alkyne groups. γ-irradiation of these gels leads to more alkyne crosslinking, enabling controlled increase of crosslink...journal article 2021
- document
-
Tack, N. (author), Wamelink, G. W.W. (author), Denkova, A.G. (author), Schouwenburg, M. (author), Hilhorst, H. (author), Wolterbeek, H.T. (author), Goedhart, P. W. (author)The Martian surface is constantly exposed to a high dose of cosmic radiation consisting of highly energetic particles and multiple types of ionizing radiation. The dose can increase temporarily by a factor of 50 through the occurrence of highly energetic solar flares. This may affect crop growth in greenhouses on the Martian surface possibly...journal article 2021
- document
-
Ma, C. (author), Vasileiadis, A. (author), Wolterbeek, H.T. (author), Denkova, A.G. (author), Serra Crespo, P. (author)The potential of the metal–organic framework UiO-66 and its functionalized derivatives for their utilization in the <sup>99</sup>Mo/<sup>99m</sup>Tc generator was assessed. Molybdenum adsorption experiments, structure characterization, molecular simulations and column experiments with molybdenum-99 were carried out. The results showed that...journal article 2021