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Lattwein, K.R. (author), Beekers, Inés (author), Kouijzer, Joop J.P. (author), Leon-Grooters, Mariël (author), Langeveld, Simone A.G. (author), van Rooij, Tom (author), van der Steen, A.F.W. (author), de Jong, N. (author), van Wamel, Willem J.B. (author), Kooiman, Klazina (author)Bacteria encased in a biofilm poses significant challenges to successful treatment, since both the immune system and antibiotics are ineffective. Sonobactericide, which uses ultrasound and microbubbles, is a potential new strategy for increasing antimicrobial effectiveness or directly killing bacteria. Several studies suggest that...journal article 2022
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Internalization of targeted microbubbles by endothelial cells and drug delivery by pores and tunnelsBeekers, Inés (author), Langeveld, Simone A.G. (author), Meijlink, Bram (author), van der Steen, A.F.W. (author), de Jong, N. (author), Verweij, M.D. (author), Kooiman, Klazina (author)Ultrasound insonification of microbubbles can locally enhance drug delivery by increasing the cell membrane permeability. To aid development of a safe and effective therapeutic microbubble, more insight into the microbubble-cell interaction is needed. In this in vitro study we aimed to investigate the initial 3D morphology of the endothelial...journal article 2022
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Panasiuk, Oleksandr (author), Hedström, Annelie (author), Langeveld, J.G. (author), Viklander, Maria (author)Infiltration and inflow (I/I) into sanitary sewers causes numerous negative effects on the whole wastewater management system and ultimately, on the receiving waters. Consequently, a number of methods have been developed to analyse the performance of sewer systems with respect to I/I, including: distributed temperature sensing (DTS), closed...journal article 2022
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van Beek, Janko (author), Teesing, Gwen (author), Oude Munnink, Bas B. (author), Meima, Abraham (author), Vriend, Henrike J. (author), Elzakkers, Jessica (author), de Graaf, Miranda (author), Langeveld, J.G. (author), Medema, G.J. (author)An outbreak of SARS-CoV-2 Alpha variant (Pango lineage B.1.1.7) was detected at a primary school (School X) in Lansingerland, the Netherlands, in December 2020. The outbreak was studied retrospectively, and population-based screening was used to assess the extent of virus circulation and decelerate transmission. Cases were SARS-CoV-2...journal article 2022
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Langeveld, J.G. (author), Cherqui, Frédéric (author), Tscheikner-Gratl, Franz (author), Muthanna, Tone Merete (author), Juarez, Marina Fernandez Delgado (author), Leitão, Joao P. (author), Roghani, Bardia (author), Kerres, Karsten (author), do Céu Almeida, Maria (author)Urban drainage systems have developed way beyond the traditional piped combined or separate sewer systems. Many ‘new’ systems are being introduced, ranging from stormwater infiltration facilities to green roofs. However, the widely advocated blue-green infrastructures are typically overlooked by asset managers, which will very likely have...journal article 2022
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Nieuwenhuis, E.M. (author), Cuppen, Eefje (author), Langeveld, J.G. (author)Urban water systems are under increased pressure from ongoing developments like climate change, population growth and urbanization. While it is clear that current urban water challenges need a more integrated approach, practitioners disagree on what such an integrated approach means exactly. Integration could therefore be described as a...journal article 2022
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Stegeman, B. (author), Hoffmann, Rob (author), Hopman, Victor (author), Langeveld, J.G. (author), Clemens-Meyer, Franҫois (author)The main application of the mobile geo-electrical measurement is the detection of the presence and determining the location of leakage in sewer systems. To do so, this method relies on the increase in the measured electrical current between an electrode inside and an electrode outside the sewer system. To use this technique for the...journal article 2022
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Makris, K. (author), Langeveld, J.G. (author), Clemens, F.H.L.R. (author)Polyvinyl chloride (PVC) sewer pipes have operated for decades in a hostile environment, raising concern among sewer managers over the longevity of their drainage systems. Inspection data (CCTV and Panoramo®) reveals that severe defects have already surfaced, yet it is unknown if the material properties of PVC sewers have been affected. In...journal article 2021
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Rietveld, M.W.J. (author), Clemens, F.H.L.R. (author), Langeveld, J.G. (author)Runoff (re)mobilises solids and their associated pollutants from streets and transports them via gully pots to the drainage system. As the solids negatively impact the performance of the drainage systems, knowledge on the solids loading in terms of mass and composition is essential. However, monitoring data on the solids loading, in...journal article 2021
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Nieuwenhuis, E.M. (author), Cuppen, Eefje (author), Langeveld, J.G. (author), de Bruijn, J.A. (author)Climate change and urbanization, as well as growing environmental and economic concerns, highlight the limitations of traditional wastewater practices and thereby challenge the management of urban water systems. Both in theory and in practice, it has been widely acknowledged that the challenges of the twenty-first century require solutions...journal article 2021
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Schang, Christelle (author), Crosbie, Nicolas D. (author), Nolan, Monica (author), Poon, Rachael (author), WANG, M. (author), Jex, Aaron (author), John, Nijoy (author), Baker, Louise (author), Langeveld, J.G. (author)The shedding of pathogens by infected humans enables the use of sewage monitoring to conduct wastewater-based epidemiology (WBE). Although most WBE studies use data from large sewage treatment plants, timely data from smaller catchments are needed for targeted public health action. Traditional sampling methods, like autosamplers or grab...journal article 2021
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van der Werf, Job (author), Kapelan, Z. (author), Langeveld, J.G. (author)To evaluate the performance of Real Time Control (RTC) of urban drainage systems (UDS) a comparison is made with the pre-RTC situation, making the RTC performance dependent on the functioning of the UDS prior to implementation. To standardise things, a generalised baseline is formulated here as the operation with optimal static settings of the...journal article 2021
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Kouijzer, Joop J.P. (author), Lattwein, Kirby R. (author), Beekers, Inés (author), Langeveld, Simone A.G. (author), Leon-Grooters, Mariël (author), Strub, Jean Marc (author), Oliva, Estefania (author), de Jong, N. (author), van der Steen, A.F.W. (author)Bacterial biofilms are a huge burden on our healthcare systems worldwide. The lack of specificity in diagnostic and treatment possibilities result in difficult-to-treat and persistent infections. The aim of this in vitro study was to investigate if microbubbles targeted specifically to bacteria in biofilms could be used both for diagnosis as...journal article 2021
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Vollaers, Vita (author), Nieuwenhuis, E.M. (author), van de Ven, F.H.M. (author), Langeveld, J.G. (author)Despite being widely implemented, sustainable urban drainage systems (SUDS) do not always function flawlessly. While SUDS have been tested extensively and seem to perform well on a laboratory or pilot scale, practitioners’ experience is different: failures in SUDS occur regularly in practice, resulting in malfunctioning systems, water...journal article 2021
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Langeveld, Simone A.G. (author), Beekers, Inés (author), Collado Lara, G. (author), van der Steen, A.F.W. (author), de Jong, N. (author), Kooiman, Klazina (author)Phospholipid-coated microbubbles are ultrasound contrast agents that can be employed for ultrasound molecular imaging and drug delivery. For safe and effective implementation, microbubbles must respond uniformly and predictably to ultrasound. Therefore, we investigated how lipid handling and phase distribution affected the variability in the...journal article 2021
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Meijer, D.H. (author), Post, Johan (author), van der Hoek, J.P. (author), Korving, Hans (author), Langeveld, J.G. (author), Clemens, F.H.L.R. (author)Drinking water distribution networks (WDNs) are a crucial infrastructure for life in cities. Deterioration of this ageing, and partly hidden from view, infrastructure can result in losses due to leakage and an increased contamination risk. To counteract this, maintenance strategies are required to maintain the service level. Information on...journal article 2021
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Rietveld, M.W.J. (author), de Rijke, D. (author), Langeveld, J.G. (author), Clemens, F.H.L.R. (author)Urban runoff (re)mobilises solids present on the street surface and transport them to urban drainage systems. The solids reduce the hydraulic capacity of the drainage system due to sedimentation and on the quality of receiving water bodies due to discharges via outfalls and combined sewer overflows (CSOs) of solids and associated pollutants....journal article 2020
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Rietveld, M.W.J. (author), Clemens, F.H.L.R. (author), Langeveld, J.G. (author)Gully pots are utilized for conveying runoff to drainage systems, as well as for reducing the system’s solids loading by retaining suspended solids. However, the accumulation of solids in gully pots reduces their removal efficiency, leading to an increase in solids transport towards the drainage system. This article aims to identify the main...journal article 2020
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Rietveld, M.W.J. (author), Clemens, F.H.L.R. (author), Langeveld, J.G. (author)Runoff entering urban drainage systems contains suspended solids, which carry pollutants and may cause blockages in downstream parts of the system (for example infiltration facilities). Suspended solids inflow should, therefore, preferably be controlled by solids removal at gully pots. This paper presents the results of lab experiments on the...journal article 2020
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Nieuwenhuis, E.M. (author), Cuppen, E.H.W.J. (author), Langeveld, J.G. (author), de Bruijn, J.A. (author)Gedreven door ontwikkelingen zoals klimaatverandering, verstedelijking en digitalisering zien we in het stedelijk watersysteem steeds vaker oplossingen ‘buiten de buis’. Oplossingen zoals publieke pleinen met een waterbergende functie, polderdaken met een dynamische waterberging, zwembaden verwarmd met warmte uit (afval)water; het zijn allemaal...journal article 2019