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Tišma, M. (author), Panoukidou, Maria (author), Antar, Hammam (author), Soh, Young Min (author), Barth, R. (author), Pradhan, B. (author), Barth, A. (author), van der Torre, J. (author), Dekker, C. (author)The ParABS system is essential for prokaryotic chromosome segregation. After loading at parS on the genome, ParB (partition protein B) proteins rapidly redistribute to distances of ~15 kilobases from the loading site. It has remained puzzling how this large-distance spreading can occur along DNA loaded with hundreds of proteins. Using in...journal article 2022
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Würthner, Laeschkir (author), Brauns, Fridtjof (author), Pawlik, G. (author), Halatek, Jacob (author), Kerssemakers, J.W.J. (author), Dekker, C. (author), Frey, Erwin (author)Self-organized pattern formation is vital for many biological processes. Reaction-diffusion models have advanced our understanding of how biological systems develop spatial structures, starting from homogeneity. However, biological processes inherently involve multiple spatial and temporal scales and transition from one pattern to another...journal article 2022
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Satam, Anuja P. (author), van der Leeden, Marike (author), de Zwart, Arjan (author), Verberne, Simon (author), Schrijvers, Jim C. (author), Hall, Michelle (author), Dekker, Joost (author), Lems, Willem F. (author), Harlaar, J. (author), van der Esch, Martin (author)Background: Muscle weakness is characteristic of knee osteoarthritis. Muscle steadiness may be an important adjunct to knee muscle strength in improving physical function in knee osteoarthritis. However, the role of muscle steadiness is uncertain. Aims: To determine the associations of knee extensor muscle steadiness with maximal voluntary...journal article 2022
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Boskeljon-Horst, L. (author), Sillem, S. (author), Dekker, S.W.A. (author)There is little empirical evidence on the predictive value of safety culture assessments (SCAs) in relation to how accident-prone an organisation might be. Recently, Antonsen not just demonstrated how a quantitative SCA mispredicted future safety outcomes, but actually showed an inverse relationship between the assessment and subsequent critical...journal article 2022
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Dekker, S.W.A. (author), Layson, Mark D. (author), Woods, David D. (author)Following other contributions about the MAX accidents to this journal, this paper explores the role of betrayal and moral injury in safety engineering related to the U.S. federal regulator’s role in approving the Boeing 737MAX—a plane involved in two crashes that together killed 346 people. It discusses the tension between humility and hubris...journal article 2022
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Li, J. (author), Li, Chenhui (author), Henneken, Vincent (author), Louwerse, Marcus (author), Van Rens, Jeannet (author), Dijkstra, Paul (author), Raz, Oded (author), Dekker, R. (author)The digitization of smart catheters will dramatically increase the demand for reliable and high data transmission in the distal tips. Optical fiber is a good candidate to provide high-speed data transmission. However, the extremely small size of the smart catheter tip, with less than a few millimeters in diameter, hampers the integration of...journal article 2022
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Blanch Jover, A. (author), De Franceschi, N. (author), Fenel, Daphna (author), Weissenhorn, Winfried (author), Dekker, C. (author)The Cdv proteins constitute the cell division system of the Crenarchaea, a machinery closely related to the ESCRT system of eukaryotes. Using a combination of TEM imaging and biochemical assays, we here present an in vitro study of Metallosphaera sedula CdvB1, the Cdv protein that is believed to play a major role in the constricting ring that...journal article 2022
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Roslon, I.E. (author), Japaridze, A. (author), Steeneken, P.G. (author), Dekker, C. (author), Alijani, F. (author)Motion is a key characteristic of every form of life<sup>1</sup>. Even at the microscale, it has been reported that colonies of bacteria can generate nanomotion on mechanical cantilevers<sup>2</sup>, but the origin of these nanoscale vibrations has remained unresolved<sup>3,4</sup>. Here, we present a new technique using drums made of...journal article 2022
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Dekker, J.J. (author), van Dongen, Jacques J.M. (author), Reinders, M.J.T. (author), Khatri, Indu (author)The IMGT database profiles the TR germline alleles for all four TR loci (TRA, TRB, TRG and TRD), however, it does not comprise of the information regarding population specificity and allelic frequencies of these germline alleles. The specificity of allelic variants to different human populations can, however, be a rich source of information...journal article 2022
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Shi, X. (author), Pumm, Anna Katharina (author), Isensee, Jonas (author), Zhao, W. (author), Verschueren, D.V. (author), Martin Gonzalez, A. (author), Golestanian, Ramin (author), Dietz, Hendrik (author), Dekker, C. (author)Flow-driven rotary motors such as windmills and water wheels drive functional processes in human society. Although examples of such rotary motors also feature prominently in cell biology, their synthetic construction at the nanoscale has remained challenging. Here we demonstrate flow-driven rotary motion of a self-organized DNA nanostructure...journal article 2022
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Dekker, H.N.J. (author), Ragni, D. (author), Baars, W.J. (author), Scarano, F. (author), Tuinstra, Marthijn (author)An experimental investigation is conducted to study the aerodynamic behavior of a two-rotor system in ground proximity. The counter-rotating rotors are placed side-by-side in the hovering condition. The time-averaged and unsteady flow behavior is studied when the rotor-to-rotor lateral distance and the distance between the rotors and the...journal article 2022
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Wen, C. (author), Bertosin, E. (author), Shi, X. (author), Dekker, C. (author), Schmid, Sonja (author)Nanopores are versatile single-molecule sensors offering a simple label-free readout with great sensitivity. We recently introduced the nanopore electro-osmotic trap (NEOtrap) which can trap and sense single unmodified proteins for long times. The trapping is achieved by the electro-osmotic flow (EOF) generated from a DNA-origami sphere...journal article 2022
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Janissen, R. (author), Eslami Mossallam, B. (author), Artsimovitch, Irina (author), Depken, S.M. (author), Dekker, N.H. (author)Pausing by bacterial RNA polymerase (RNAp) is vital in the recruitment of regulatory factors, RNA folding, and coupled translation. While backtracking and intra-structural isomerization have been proposed to trigger pausing, our mechanistic understanding of backtrack-associated pauses and catalytic recovery remains incomplete. Using high...journal article 2022
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Bengtson, M.L. (author), Bharadwaj, M. (author), Franch, O. (author), van der Torre, J. (author), Meerdink, V.E.E. (author), Schallig, Henk (author), Dekker, C. (author)Nucleic-acid detection is crucial for basic research as well as for applications in medicine such as diagnostics. In resource-limited settings, however, most DNA-detection diagnostic schemes are inapplicable since they rely on expensive machinery, electricity, and trained personnel. Here, we present an isothermal DNA detection scheme for the...journal article 2022
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Kim, E. (author), Martin Gonzalez, A. (author), Pradhan, B. (author), van der Torre, J. (author), Dekker, C. (author)Condensin, a structural maintenance of chromosomes (SMC) complex, has been shown to be a molecular motor protein that organizes chromosomes by extruding loops of DNA. In cells, such loop extrusion is challenged by many potential conflicts, for example, the torsional stresses that are generated by other DNA-processing enzymes. It has so far...journal article 2022
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Mazur, G.P. (author), van Loo, N. (author), Wang, J. (author), Dvir, T. (author), Wang, Guanzhong (author), Korneychuk, S. (author), Borsoi, F. (author), Dekker, R.C. (author), Badawy, G.H.A. (author), Vinke, Peter (author), Quintero Perez, M. (author), Heedt, S. (author), Kouwenhoven, Leo P. (author)In superconducting quantum circuits, aluminum is one of the most widely used materials. It is currently also the superconductor of choice for the development of topological qubits. However, aluminum-based devices suffer from poor magnetic field compatibility. Herein, this limitation is resolved by showing that adatoms of heavy elements (e.g.,...journal article 2022
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Fragasso, A. (author), de Vries, Hendrik W. (author), Andersson, John (author), van der Sluis, E.O. (author), van der Giessen, Erik (author), Onck, Patrick R. (author), Dekker, C. (author)Nuclear pore complexes (NPCs) regulate all molecular transport between the nucleus and the cytoplasm in eukaryotic cells. Intrinsically disordered Phe-Gly nucleoporins (FG-Nups) line the central conduit of NPCs to impart a selective barrier where large proteins are excluded unless bound to a transport receptor (karyopherin; Kap). Here, we...journal article 2022
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Chardon, Florian (author), Japaridze, A. (author), Witt, Hannes (author), Velikovsky, Leonid (author), Chakraborty, Camellia (author), Wilhelm, Therese (author), Dumont, Marie (author), Yang, W.W.W. (author), Dekker, C. (author)Chromosome inheritance depends on centromeres, epigenetically specified regions of chromosomes. While conventional human centromeres are known to be built of long tandem DNA repeats, much of their architecture remains unknown. Using single-molecule techniques such as AFM, nanopores, and optical tweezers, we find that human centromeric DNA...journal article 2022
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Fayezioghani, A. (author), Dekker, R. (author), Sluys, Lambertus J. (author)Structural components in corrosive environments such as pipelines, bridges, aircrafts, and turbines are imposed to stress corrosion. A stress corrosion model for pit growth should a) accurately consider the electrochemistry of the corrosion process, b) properly deal with the moving interface between solid and electrolyte, and c) effectively...journal article 2022
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Boskeljon-Horst, Leonie (author), J. de Boer, Robert (author), Sillem, S. (author), Dekker, Sidney W. A. (author)In this study we identify the differences in goal realisation when applying two conflicting paradigms regarding rule perception and management. We gathered more than 30 scenarios where goal conflicts were apparent in a military operational unit. We found that operators repetitively utilized certain routines in executing their tasks in an effort...journal article 2022