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Hollmann, F. (author), Arends, I.W.C.E. (author)Biocatalysis is propagating into practically every area of organic chemistry, amongst them radical polymerizations. A review of the recent developments of this dynamic and quickly evolving area of research is presented together with a critical evaluation of its potential to yield novel polymers and/or environmentally more benign synthetic...journal article 2012
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Kara, S. (author), Spickermann, D. (author), Schrittwieser, J.H. (author), Leggewie, C. (author), Van Berkel, W.J.H. (author), Arendsa, I.W.C.E. (author), Hollmann, F. (author)1,4-Butanediol is shown to be an efficient cosubstrate to promote NAD(P)H-dependent redox biocatalysis. The thermodynamically and kinetically inert lactone coproduct makes the regeneration reaction irreversible. Thereby not only the molar surplus of cosubstrate is dramatically reduced but also faster reaction rates are obtained.journal article 2012
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De Torres, M. (author), Dimroth, J. (author), Arends, I.W.C.E. (author), Keilitz, J. (author), Hollmann, F. (author)Rh(III)-TsDPEN, an immobilized analog of the well-known [Cp*Rh(bpy)(H2O)]2+ was evaluated as a heterogeneous, recyclable regeneration catalyst for reduced oxidoreductase cofactors [NAD(P)H]. Repeated use of this catalyst was established and the catalytic properties were initially investigated. Apparently, Rh(III)-TsDPEN is prone to severe...journal article 2012
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Holtmann, D. (author), Fraaije, M.W. (author), Arends, I.W.C.E. (author), Oppermand, D.J. (author), Hollmann, F. (author)The scope and limitations of oxygenases as catalysts for preparative organic synthesis is discussed.journal article 2014
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Schrittwieser, J. (author), Coccia, F. (author), Kara, S. (author), Grischek, B. (author), Kroutil, W. (author), d'Alessandro, N. (author), Hollmann, F. (author)One-pot combinations of sequential catalytic reactions can offer practical and ecological advantages over classical multi-step synthesis schemes. In this context, the integration of enzymatic and chemo-catalytic transformations holds particular potential for efficient and selective reaction sequences that would not be 10 possible using either...journal article 2013
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Kochius, S. (author), Magnusson, A.O. (author), Hollmann, F. (author), Schrader, J. (author), Holtmann, D. (author)The applicability of dissolved redox mediators for NAD(P)+ regeneration has been demonstrated several times. Nevertheless, the use of mediators in solutions for sensor applications is not a very convenient strategy since the analysis is not reagentless and long stabilization times occur. The most important drawbacks of dissolved mediators in...journal article 2012
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Bormann, S. (author), Gomez Baraibar, A. (author), Ni, Y. (author), Holtmann, D. (author), Hollmann, F. (author)Peroxygenases enable H2O2-driven oxyfunctionalisation of organic compounds such as selective epoxidation, hydroxylation and heteroatom oxygenation. Therefore, peroxygenases are potentially very useful tools for the organic chemist. This contribution reviews the current state of the art in peroxygenases, their availability, engineering and...journal article 2015
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- Perez de los Rios, A. (author), Irabien, A. (author), Hollmann, F. (author), Fernandez, J.H. (author) journal article 2013
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Perez, D.I. (author), Grau, M.M. (author), Arends, I.W.C.E. (author), Hollmann, F. (author)Robust peroxidase-catalyzed enantiospecific oxyfunctionalizations can be achieved by simple light-driven in situ generation of hydrogen peroxide.journal article 2009
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Lloret, L. (author), Hollmann, F. (author), Eibes, G. (author), Feijoo, G. (author), Moreira, M.T. (author), Lema, J.M. (author)Laccase from Myceliophthora thermophila was covalently immobilised on Eupergit C and Eupergit C 250L yielding specific activities of up to 17 and 80 U/g, respectively. Due to its superior activity, Eupergit C 250L was chosen for further research. The somewhat lower catalytic efficiency (based on the ratio between the turnover number and the...journal article 2011
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Burek, Bastien O. (author), Dawood, A.W.H. (author), Hollmann, F. (author), Liese, Andreas (author), Holtmann, Dirk (author)Enzyme catalysis, made tremendous progress over the last years in identification of new enzymes and new enzymatic reactivity’s as well as optimization of existing enzymes. However, the performance of the resulting processes is often still limited, e.g., in regard of productivity, realized product concentrations and the stability of the enzymes....journal article 2022
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Silva de Miranda, Amanda (author), Milagre, C.D.D.F. (author), Hollmann, F. (author)Alcohol dehydrogenases (ADHs) have become important catalysts for stereoselective oxidation and reduction reactions of alcohols, aldehydes and ketones. The aim of this contribution is to provide the reader with a timely update on the state-of-the-art of ADH-catalysis. Mechanistic basics are presented together with practical information about the...journal article 2022
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Hilberath, T. (author), van Troost, A.G.L. (author), Alcalde, Miguel (author), Hollmann, F. (author)The use of water-miscible organic co-solvents in biocatalysis is a simple procedure for obtaining higher enzymatic activities toward hydrophobic substrates. However, effects on activity and stability have to be carefully evaluated, also with regard to the type and concentration of the respective co-solvent. In this contribution, we investigated...journal article 2022
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Holtmann, Dirk (author), Hollmann, F. (author)Process intensification aims at enabling bridging the gap between fundamental research such as identification of new catalysts and reactions and their implementation in industrial environments. Especially the field of biocatalysis has seen some tremendous improvements and the development of new tools and approaches to bridge this gap. In this...journal article 2021
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- Holtmann, Dirk (author), Hollmann, F. (author) journal article 2022
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Bouchaut, B.F.H.J. (author), Hollmann, F. (author), Asveld, L. (author)The increasing societal demand for safer, biobased products, and processes<br/>creates opportunities for industrial biotechnology and chemistry. To succeed,<br/>controlled learning about new emerging risks is crucial but both fields endure<br/>difficulty in doing so by their respective regulation and risk management culture.journal article 2022
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Puchľová, Eva (author), Hilberath, T. (author), Vranková, Kvetoslava (author), Hollmann, F. (author)Non-enantioselective alcohol dehydrogenases (ADHs) are rarely found in the biocatalysis portfolio. Generally, highly enantioselective ADHs are sought for. Using such ADHs for the oxidation of racemic alcohols generally results in a kinetic resolution of the starting material, which is unfavourable if the ketone represents the product of interest...journal article 2022
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França, Alexandre S. (author), Brêda, Gabriela C. (author), De Oliveira, Kleber T. (author), Almeida, Rodrigo V. (author), Hollmann, F. (author), de Souza, Rodrigo O.M.A. (author)A visible-light-driven photocatalytic decarboxylation of palmitic acid and related fatty acids is described in this study. Remarkable decarboxylation rates have been observed with full conversion in less than 20 min. In this study, we have<br/>demonstrated that sunlight irradiation, even on cloudy days, can deliver similar results to traditional...journal article 2023
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Knaus, T (author), Paul, C.E. (author), Levy, CW (author), de Vries, S. (author), Mutti, FG (author), Hollmann, F. (author), Scrutton, NS (author)The search for affordable, green biocatalytic processes is a challenge for chemicals manufacture. Redox biotransformations are potentially attractive, but they rely on<br/>unstable and expensive nicotinamide coenzymes that have prevented their widespread exploitation. Stoichiometric use of natural coenzymes is not viable economically, and the...journal article 2016
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- Bornadel, A (author), Hatti-Kaul, R (author), Hollmann, F. (author), Kara, S (author) journal article 2015