Orientation-Locked DNA Origami for Stable Trapping of Small Proteins in the Nanopore Electro-Osmotic Trap

Nanopores are versatile single-molecule sensors offering a simple label-free readout with great sensitivity. We recently introduced the nanopore electro-osmotic trap (NEOtrap) which can trap and sense single unmodified proteins for long times. The trapping is achieved by the electro-osmotic flow (EOF) generated from a DNA-origami sphere...

Ultra-Stretchable Interconnects for High-Density Stretchable Electronics

The exciting field of stretchable electronics (SE) promises numerous novel applications, particularly in-body and medical diagnostics devices. However, future advanced SE miniature devices will require high-density, extremely stretchable interconnects with micron-scale footprints, which calls for proven standardized (complementary metal-oxide...

Coating of graphene

The present invention is in the field of highly crystalline graphene and coating said graphene with a layer. Said graphene may have further structures, such as nanopores, nanogaps, and nanoribbons. The coated graphene can be used for biomolecular analysis and modification, such as DNA-sequencing, as a sensor, etc. The invention therefor also...

Skewed brownian fluctuations in single-molecule magnetic tweezers.

Measurements in magnetic tweezers rely upon precise determination of the position of a magnetic microsphere. Fluctuations in the position due to Brownian motion allows calculation of the applied force, enabling deduction of the force-extension response function for a single DNA molecule that is attached to the microsphere. The standard approach...

Design of an ergonomic electric guitar

An investigation of existing literature reveals that guitar players are most prone to musculoskeletal injuries amongst all musicians. In the light of recent injuries to prominent guitar players such as Eddie Van Halen, this article explores ergonomics of electric guitars. By means of surveys, user observations, biomechanical analysis and...

Flexible labor and innovation performance: Evidence from longitudinal firm-level data

Firms with high shares of workers on fixed-term contracts have significantly higher sales of imitative new products but perform significantly worse on sales of innovative new products (“first on the market”). High functional flexibility in “insider-outsider” labor markets enhances a firm’s new product sales, as do training efforts and highly...

Parallel minimal norm method for tridiagonal linear systems

Spontaneous resistance switching and low-frequency noise in quantum point contacts

Electrochemical vapor deposition of SOFC [solid oxide fuel cell] components

A simulation tool for the study of satellite based navigation systems

Erosiebestendigheid van gras op klei taluds