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Liefaard, Marte C. (author), Moore, Kat S. (author), Mulder, Lennart (author), van den Broek, Daan (author), Wesseling, Jelle (author), Sonke, Gabe S. (author), Wessels, L.F.A. (author), Rookus, Matti (author), Lips, Esther H. (author)Background: Studies have shown that blood platelets contain tumour-specific mRNA profiles tumour-educated platelets (TEPs). Here, we aim to train a TEP-based breast cancer detection classifier. Methods: Platelet mRNA was sequenced from 266 women with stage I–IV breast cancer and 212 female controls from 6 hospitals. A particle swarm optimised...journal article 2023
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Carmiggelt, J.J. (author), Bertelli, I. (author), Mulder, R.W. (author), Teepe, A. (author), Elyasi, Mehrdad (author), Simon, B.G. (author), Bauer, G.E. (author), Blanter, Y.M. (author), van der Sar, T. (author)Quantum sensing has developed into a main branch of quantum science and technology. It aims at measuring physical quantities with high resolution, sensitivity, and dynamic range. Electron spins in diamond are powerful magnetic field sensors, but their sensitivity in the microwave regime is limited to a narrow band around their resonance...journal article 2023
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Mulder, J.T. (author), Meijer, M.S. (author), van Blaaderen, J.J. (author), du Fossé, I. (author), Jenkinson, Kellie (author), Bals, Sara (author), Manna, Liberato (author), Houtepen, A.J. (author)Ytterbium-doped LiYF4 (Yb:YLF) is a commonly used material for laser applications, as a photon upconversion medium, and for optical refrigeration. As nanocrystals (NCs), the material is also of interest for biological and physical applications. Unfortunately, as with most phosphors, with the reduction in size comes a large reduction of the...journal article 2023
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Gordon, Kenneth E. (author), Karalidi, Theodora (author), Bott, Kimberly M. (author), Miles-Páez, Paulo A. (author), Mulder, W. (author), Stam, D.M. (author)In the JWST, Extremely Large Telescopes, and LUVOIR era, we expect to characterize a number of potentially habitable Earth-like exoplanets. However, the characterization of these worlds depends crucially on the accuracy of theoretical models. Validating these models against observations of planets with known properties will be key for the...journal article 2023
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Mulder, W.A. (author)Finite elements with polynomial basis functions on the simplex with a symmetric distribution of nodes should have a unique polynomial representation. Unisolvence not only requires that the number of nodes equals the number of independent polynomials spanning a polynomial space of a given degree, but also that the Vandermonde matrix...journal article 2023
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Fasching, L.R. (author), Zhu, P. (author), Mulder, Atticus (author), Beltrao, Gabriel Spiller (author), Neeleman, Yannick (author), Rwei, A.Y. (author)Accurate and real-time monitoring of biomarker proteins, such as Tumor Necrosis Factor (TNF) alpha, plays a vital role in early disease diagnosis, effective treatment design, and personalized health management strategies. However, existing detection methods, including enzyme-linked immunosorbent assay (ELISA), radioimmune assays (RIA), and...conference paper 2023
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de Rooij, G. (author), van Baelen, D. (author), Borst, C. (author), van Paassen, M.M. (author), Mulder, Max (author)Haptic cues on the side stick are a promising method to reduce loss of control in-flight incidents. They can be intuitively interpreted and provide immediate support, leading to a shared control system. However, haptic interfaces are limited in providing information, and the reason for cues may not always be clear to pilots. This study presents...journal article 2023
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Croon, T.M. (author), Hoekstra, J.S.C.M. (author), Elsinga, M.G. (author), Dalla Longa, F. (author), Mulder, Peter (author)Recent energy price spikes have led to increased energy poverty among low-income households living in inefficient homes. Accurate statistics on energy poverty help inform resource allocation and better target relief schemes and retrofit funds. Existing indicators are predominantly defined in terms of a headcount ratio – the share of population...journal article 2023
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Kuipers, J.R. (author), de Winter, J.C.F. (author), Mulder, Max (author)Background: Even though accompanied driving and simulator training are common, clarity on their usage trends and effectiveness is lacking. This research aimed to deepen the understanding of the relationships between personal characteristics, pre-licence accompanied driving, self-reported post-licence driving behaviour, and driving performance...journal article 2023
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Jones, Keith (author), Mulder, Femke (author), Morga, Mariantonietta (author), Wanigarathna, Nadeeshani (author)Background and aim - Improving the resilience of business organisations and critical infrastructure providers to disaster events is a major challenge facing many European organisations. Recent floods in Germany, Belgium and the Netherlands and earthquakes in Iceland, Italy, Romania and Greece have demonstrated the need for organisations to adopt...conference paper 2022
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de Boer, Bas (author), Strasser, C. (author), Mulder, S.S. (author)Medicine is increasingly focusing on the prevention of diseases. The digital twin (DT) is considered to be an important technological development for realizing this transition. Broadly speaking, a DT is an in silico representation of an individual that dynamically reflects molecular and physiological status, which makes it possible to monitor...journal article 2022
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Di Staso, D. (author), Mulder, I. (author), Janssen, M.F.W.H.A. (author), Kleiman, F. (author)Open data can support the creation of new services, facilitate research, and provide insights into everyday issues affecting citizens. Although public administrations are making efforts to create sustainable and inclusive open data systems, there is limited capacity to identify suitable datasets, clean, release, and reuse them. Serious games...journal article 2022
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Mulder, W.A. (author)Finite elements with mass lumping allow for explicit time stepping when modelling wave propagation and can be more efficient than finite differences in complex geological settings. In 2D on quadrilaterals, spectral elements are the obvious choice. Triangles are more flexible for meshing, but the construction of polynomial elements is less...conference paper 2022
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- Ruan, J. (author), Masfara, La ODE Marzujriban (author), Ghose, R. (author), Mulder, W.A. (author) abstract 2022
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- Cupillard, Paul (author), Mulder, W.A. (author) abstract 2022
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Mulder, I. (author), Magni, A. (author)Design is generally accepted to provide valuable contributions to addressing complex societal challenges. Even though design and engineering professionals show increasingly capable of making societal impact, it is not straightforward why some creative practices are more impactful in fostering systemic change, let alone what additional...conference paper 2022
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Ruan, J. (author), Masfara, La ODE Marzujriban (author), Ghose, R. (author), Mulder, W.A. (author)Geomechanical modelling is generally used to simulate the nucleation of induce d earthquakes in, for instance the Groningen gas field. We apply quasi static simulation to investigate the stress changes from gas production. When a fault reaches a critical state, dynamic simulation provides information on the dynamic rupture during ea rthqu ake...poster 2022
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Kolff, M.J.C. (author), Venrooij, Joost (author), Schwienbacher, Markus (author), Pool, D.M. (author), Mulder, Max (author)BMW’s new driving simulation center operates multiple motion-base simulators – each with a different kinematic configuration – to serve various experiment use-cases and requirements of simulator users. The selection of a simulator for each experiment should ideally be based on their relative strengths and weaknesses. To support this decision...conference paper 2022
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Mulder, I. (author), Buckenmayer, M.B. (author), Murphy, Ryan J.A. (author)Scaling is a motif describing the proportionate growth of innovation. Over the past decade, scholars have adapted the original idea of scaling from business to differentiate different ways to scale that are more appropriate in the context of social innovation. Scaling is sometimes thought of as a panacea: it is the end result, purpose, or answer...conference paper 2022
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Odayakulam Balasubramaniam, D. (author), Brown, P.D. (author), Calderon Gonzalez, A. (author), Mulder, I. (author)Circular economy has gained traction within companies resulting in many exploring new product and business model combinations. Yet, to transition towards a circular economy on a societal level requires going beyond new product and market-based opportunities. To enable societal level change, ecosystem-level innovations are important and so...conference paper 2022