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Metzemaekers, Jeroen (author), Slotboom, Suzanne (author), Sampat, Jonathan (author), Vermolen, Polo (author), Smeets, Mathilde J.G.H. (author), Elske van den Akker-van Marle, M. (author), Maas, Jacques (author), Bakker, Esther C. (author), Nijkamp, Marjan (author), Both, S. (author), Jansen, F.W. (author)Objective: To study the experiences, considerations, and motivations of patients with endometriosis in the decision-making process for deep endometriosis (DE) treatment options. Design: Qualitative study using semi-structured in-depth focus group methodology. Setting: University medical center. Patient(s): A total of 19 Dutch women diagnosed...journal article 2021
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Tesi, N. (author), Hulsman, M. (author), van der Lee, S.J. (author), Jansen, Iris E. (author), Stringa, N. (author), van Schoor, Natasja M. (author), Scheltens, Philip (author), Reinders, M.J.T. (author), Holstege, H. (author)Human longevity is influenced by the genetic risk of age-related diseases. As Alzheimer’s disease (AD) represents a common condition at old age, an interplay between genetic factors affecting AD and longevity is expected. We explored this interplay by studying the prevalence of AD-associated single-nucleotide-polymorphisms (SNPs) in...journal article 2021
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Jochems, Fleur (author), Thijssen, Bram (author), De Conti, Giulia (author), Jansen, Robin (author), Pogacar, Ziva (author), Groot, Kelvin (author), Wang, Liqin (author), Schepers, Arnout (author), Wessels, L.F.A. (author)Cellular senescence is characterized as a stable proliferation arrest that can be triggered by multiple stresses. Most knowledge about senescent cells is obtained from studies in primary cells. However, senescence features may be different in cancer cells, since the pathways that are involved in senescence induction are often deregulated in...journal article 2021
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Diaz Cortes, Gabriela Berenice (author), Vuik, Cornelis (author), Jansen, J.D. (author)We explore and develop a Proper Orthogonal Decomposition (POD)-based deflation method for the solution of ill-conditioned linear systems, appearing in simulations of two-phase flow through highly heterogeneous porous media. We accelerate the convergence of a Preconditioned Conjugate Gradient (PCG) method achieving speed-ups of factors up to...journal article 2021
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Residential satisfaction of private tenants in China's superstar cities: The case of Shenzhen, ChinaLi, B. (author), Jin, C. (author), Jansen, S.J.T. (author), van der Heijden, H.M.H. (author), Boelhouwer, P.J. (author)In recent years, Chinese housing policies have been shifting from encouraging homeownership toward developing the private rented sector, especially in the superstar cities. Nevertheless, what are the target groups and characteristics of private rental housing in Chinese superstar cities, and whether the private rental housing is capable of...journal article 2021
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Wang, Qinyu (author), Senatore, Gennaro (author), Jansen, K.M.B. (author), Habraken, Arjan (author), Teuffel, Patrick (author)This paper presents numerical and experimental studies on semi-active seismic response control of structures equipped with variable stiffness and damping structural joints. Such adaptive joints, which are comprised of a shape memory polymer (SMP) core reinforced by an SMP-aramid composite skin, function as load-transfer components as well as...journal article 2021
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Tesi, N. (author), Stringa, N. (author), Hadjigeorgiou, Georgios (author), Hulsman, M. (author), van Schoor, Natasja M. (author), Ruiz, A. (author), Jansen, Iris E. (author), Holstege, H. (author), van der Lee, S.J. (author)Genetic discoveries of Alzheimer’s disease are the drivers of our understanding, and together with polygenetic risk stratification can contribute towards planning of feasible and efficient preventive and curative clinical trials. We first perform a large genetic association study by merging all available case-control datasets and by-proxy...journal article 2021
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Gijón Mancheño, A. (author), Jansen, Wiljan (author), Winterwerp, J.C. (author), Uijttewaal, W.S.J. (author)Mangrove vegetation provides natural protection against coastal hazards like flooding and erosion. In spite of their economic and societal value, mangrove forests have experienced a worldwide decline due to human activities. Bamboo structures, formed by poles driven into the soil, are being used to create a sheltered environment for mangrove...journal article 2021
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Reus, Lianne M. (author), Jansen, Iris E. (author), van Rooij, Jeroen (author), van Schoor, Natasja M. (author), Tesi, N. (author), Reinders, M.J.T. (author), Huisman, M.A. (author), van der Lugt, Aad (author), van der Lee, Sven J. (author)Genetic factors play a major role in frontotemporal dementia (FTD). The majority of FTD cannot be genetically explained yet and it is likely that there are still FTD risk loci to be discovered. Common variants have been identified with genome-wide association studies (GWAS), but these studies have not systematically searched for rare variants...journal article 2021
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de Groot, Lennart V. (author), Fabian, Karl (author), Béguin, Annemarieke (author), Kosters, Martha E. (author), Cortés-Ortuño, David (author), Fu, Roger R. (author), Jansen, Chloë M.L. (author), Harrison, Richard J. (author), van Leeuwen, Tristan (author), Barnhoorn, A. (author)Our understanding of the past behavior of the geomagnetic field arises from magnetic signals stored in geological materials, e.g., (volcanic) rocks. Bulk rock samples, however, often contain magnetic grains that differ in chemistry, size, and shape; some of them record the Earth's magnetic field well, others are unreliable. The presence of a...journal article 2021
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Gijón Mancheño, A. (author), Jansen, W. (author), Uijttewaal, W.S.J. (author), Reniers, A.J.H.M. (author), van Rooijen, A. A. (author), Suzuki, T. (author), Etminan, V. (author), Winterwerp, J.C. (author)Mangrove vegetation constitutes a natural coastal defence against waves and erosion. Despite their protective role, mangrove ecosystems have experienced continuous degradation over the last decades due to human causes. At retreating mangrove coastlines, bamboo structures are built to create new habitat for mangrove colonization. Existing...journal article 2021
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Teunissen, L.P.J. (author), Janssen, E.S. (author), Schootstra, J. (author), Plaude, L. (author), Jansen, K.M.B. (author)Eleven phase change materials (PCMs) for cooling humans in heat-stressed conditions were evaluated for their cooling characteristics. Effects of packaging material and segmentation were also investigated. Sample packs with a different type PCM (water- and oil-based PCMs, cooling gels, inorganic salts) or different packaging (aluminum, TPU,...journal article 2021
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Wang, Qinyu (author), Senatore, Gennaro (author), Jansen, K.M.B. (author), Habraken, Arjan (author), Teuffel, Patrick (author)This paper presents experimental testing of a new semi-active vibration control device comprising a shape memory polymer (SMP) core that is reinforced by an SMP-aramid composite skin. This control device works as a load-transfer component that can be integrated into truss and frame structures in the form of a joint. At the material level,...journal article 2021
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de Korte, Johannus Q. (author), Bongers, Coen C.W.G. (author), Hopman, Maria T.E. (author), Teunissen, L.P.J. (author), Jansen, K.M.B. (author), Kingma, Boris R.M. (author), Ballak, Sam B. (author), Maase, Kamiel (author), Moen, Maarten H. (author)The environmental conditions during the Tokyo Olympic and Paralympic Games are expected to be challenging, which increases the risk for participating athletes to develop heat-related illnesses and experience performance loss. To allow safe and optimal exercise performance of Dutch elite athletes, the Thermo Tokyo study aimed to determine...journal article 2021
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Genetics Contributes to Concomitant Pathology and Clinical Presentation in Dementia with Lewy Bodiesvan der Lee, S.J. (author), van Steenoven, Inger (author), van de Beek, Marleen (author), Tesi, N. (author), Jansen, Iris E. (author), van Schoor, N.M. (author), Reinders, M.J.T. (author), Huisman, Martijn (author), Scheltens, Philip (author)Background: Dementia with Lewy bodies (DLB) is a complex, progressive neurodegenerative disease with considerable phenotypic, pathological, and genetic heterogeneity. Objective: We tested if genetic variants in part explain the heterogeneity in DLB. Methods: We tested the effects of variants previously associated with DLB (near APOE, GBA, and...journal article 2021
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Kooijman, L. (author), Dodou, D. (author), Jansen, S. T. (author), Themans, T. S. (author), Russell, J. N.M. (author), Petermeijer, S.M. (author), Doorman, J. R.C. (author), Hablé, J. H. (author), Neubert, D. S. (author), Vos, M. J.C. (author), de Winter, J.C.F. (author)Much psychological research uses pupil diameter measurements to investigate the cognitive and emotional effects of visual stimuli. A potential problem is that accommodating at a nearby point causes the pupil to constrict. This study examined to what extent accommodation is a confounder in pupillometry research. Participants solved...journal article 2021
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Varotto, Silvia F. (author), Jansen, Reinier (author), Bijleveld, Frits (author), van Nes, C.N. (author)Automatic incident detection (AID) systems and variable speed limits (VSLs) can reduce crash probability and traffic congestion. Studies based on loop detector data have shown that AID systems decrease the variation in speeds between drivers. Despite the impact on driver behaviour characteristics, most mathematical models evaluating the...journal article 2021
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Bozali, B. (author), van Dam, J.J.F. (author), Plaude, L. (author), Jansen, K.M.B. (author)Smart textiles have been attracting considerable interest in imparting a wide range of functions to traditional clothing ranging from sensing, actuation, data processing, and energy storage. In the case of textile-based strain sensors, most of the studies proved that they can work in principle, however, producing strain sensors with desirable...conference paper 2021
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Steijlen, A.S.M. (author), Bastemeijer, J. (author), Nederhoff, R.J. (author), Jansen, K.M.B. (author), French, P.J. (author), Bossche, A. (author)Ammonium levels in sweat can potentially be used to measure muscle fatigue and to diagnose particular metabolic myopathies. To research the potential use of ammonia in sweat as a biomarker, a new real-time monitoring system is developed. This system consists of a capsule that is placed on the skin and ventilated with dry air. A metal-oxide...journal article 2021
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Novikov, A. (author), Voskov, D.V. (author), Khait, M. (author), Hajibeygi, H. (author), Jansen, J.D. (author)We develop a collocated Finite Volume Method (FVM) to study induced seismicity as a result of pore pressure fluctuations. A discrete system is obtained based on a fully-implicit coupled description of flow, elastic deformation, and contact mechanics at fault surfaces on a fully unstructured mesh. The cell-centered collocated scheme leads to...conference paper 2021