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Mirzaali, Mohammad J. (author), Pahlavani, H. (author), Yarali, E. (author), Zadpoor, A.A. (author)Non-affine deformations enable mechanical metamaterials to achieve their unusual properties while imposing implications for their structural integrity. The presence of multiple phases with different mechanical properties results in additional non-affinity of the deformations, a phenomenon that has never been studied before in the area of...journal article 2020
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Li, Y. (author), Pavanram, P. (author), Zhou, J. (author), Lietaert, K. (author), Bobbert, F.S.L. (author), Kubo, Yusuke (author), Leeflang, M.A. (author), Jahr, H. (author), Zadpoor, A.A. (author)Topological design provides additively manufactured (AM) biodegradable porous metallic biomaterials with a unique opportunity to adjust their biodegradation behavior and mechanical properties, thereby satisfying the requirements for ideal bone substitutes. However, no information is available yet concerning the effect of topological design on...journal article 2020
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Koolen, Marianne (author), Amin Yavari, S. (author), Lietaert, Karel (author), Wauthle, Ruben (author), Zadpoor, A.A. (author), Weinans, Harrie (author)Additively manufactured (AM) porous metallic biomaterials, in general, and AM porous titanium, in particular, have recently emerged as promising candidates for bone substitution. The porous design of such materials allows for mimicking the elastic mechanical properties of native bone tissue and showed to be effective in improving bone...journal article 2020
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Yu, K. (author), Balasubramanian, S. (author), Pahlavani, H. (author), Mirzaali, Mohammad J. (author), Zadpoor, A.A. (author), Aubin-Tam, M.E. (author)Natural materials, such as nacre and silk, exhibit both high strength and toughness due to their hierarchical structures highly organized at the nano-, micro-, and macroscales. Bacterial cellulose (BC) presents a hierarchical fibril structure at the nanoscale. At the microscale, however, BC nanofibers are distributed randomly. Here, BC self...journal article 2020
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de Witte, Tinke Marie (author), Wagner, Angela M. (author), Fratila-Apachitei, E.L. (author), Zadpoor, A.A. (author), Peppas, Nicholas A. (author)Bone tissue engineering strategies have been developed to address the limitations of the current gold standard treatment options for bone-related disorders. These systems consist of an engineered scaffold that mimics the extracellular matrix and provides an architecture to guide the natural bone regeneration process, and incorporated growth...journal article 2020
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Li, Y. (author), Pavanram, P. (author), Zhou, J. (author), Lietaert, K. (author), Taheri, P. (author), Li, W. (author), San, H. (author), Leeflang, M.A. (author), Mol, J.M.C. (author), Jahr, H. (author), Zadpoor, A.A. (author)Additively manufacturing (AM) opens up the possibility for biodegradable metals to possess uniquely combined characteristics that are desired for bone substitution, including bone-mimicking mechanical properties, topologically ordered porous structure, pore interconnectivity and biodegradability. Zinc is considered to be one of the promising...journal article 2020
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Dong, J. (author), Li, Y. (author), Lin, P. (author), Leeflang, M.A. (author), van Asperen, S. (author), Yu, K. (author), Tümer, N. (author), Norder, B. (author), Zadpoor, A.A. (author), Zhou, J. (author)Biodegradable porous magnesium (Mg) scaffolds are promising for application in the regeneration of critical-sized bone defects. Although additive manufacturing (AM) carries the promise of offering unique opportunities to fabricate porous Mg scaffolds, current attempts to apply the AM approach to fabricating Mg scaffolds have encountered some...journal article 2020
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Nouri Goushki, M. (author), Mirzaali, Mohammad J. (author), Angeloni, L. (author), Fan, D. (author), Minneboo, M.B. (author), Ghatkesar, M.K. (author), Staufer, U. (author), Fratila-Apachitei, E.L. (author), Zadpoor, A.A. (author)Fabricating large areas of geometrically complex and precisely controlled topographies is required for the studies of cell behavior on patterned surfaces. Direct laser writing (DLW) is an advanced 3D-fabrication technique, which facilitates the manufacturing of structures within various scales (from a few hundred nanometers to millimeters)....journal article 2020
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Zhang, Yichuan (author), Venkateswaran, Seshasailam (author), Higuera, Gustavo A. (author), Nath, Suvra (author), Shpak, Guy (author), Matray, Jeffrey (author), Fratila-Apachitei, E.L. (author), Zadpoor, A.A. (author), Kushner, Steven A. (author), Bradley, Mark (author), De Zeeuw, Chris I. (author)Substrates for neuron culture and implantation are required to be both biocompatible and display surface compositions that support cell attachment, growth, differentiation, and neural activity. Laminin, a naturally occurring extracellular matrix protein is the most widely used substrate for neuron culture and fulfills some of these...journal article 2020
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Ganjian, M. (author), Angeloni, L. (author), Mirzaali, Mohammad J. (author), Modaresifar, K. (author), Hagen, C.W. (author), Ghatkesar, M.K. (author), Hagedoorn, P.L. (author), Fratila-Apachitei, E.L. (author), Zadpoor, A.A. (author)One of the methods to create sub-10 nm resolution metal-composed 3D nanopillars is electron beam-induced deposition (EBID). Surface nanotopographies (e.g., nanopillars) could play an important role in the design and fabrication of implantable medical devices by preventing the infections that are caused by the bacterial colonization of the...journal article 2020
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Tümer, N. (author), Arbabi, V. (author), Gielis, Willem Paul (author), de Jong, Pim A. (author), Weinans, Harrie (author), Tuijthof, Gabrielle J.M. (author), Zadpoor, A.A. (author)The bones forming the talocrural joint (TCJ) and subtalar joint (STJ) are often assumed to be bilaterally symmetric. Therefore, the contralateral limb (i.e. the fibula, tibia, calcaneus and talus) is used as a template or an intra-subject control in clinical and research practice. However, the validity of the symmetry assumption is...journal article 2019
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Li, Y. (author), Lietaert, K. (author), Li, W. (author), Zhang, X.Y. (author), Leeflang, M.A. (author), Zhou, J. (author), Zadpoor, A.A. (author)The corrosion fatigue behavior of additively manufactured topologically ordered porous iron based on diamond unit cells was studied for the first time to understand its response to cyclic loading in a simulated physiological environment. The material exhibited high fatigue resistance with fatigue strengths being 70% and 65% of yield stress in...journal article 2019
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Widyaratih, Dwisetya S. (author), Hagedoorn, P.L. (author), Otten, L.G. (author), Ganjian, M. (author), Tümer, N. (author), Apachitei, I. (author), Hagen, C.W. (author), Fratila-Apachitei, E.L. (author), Zadpoor, A.A. (author)Recent discoveries have shown that nanopatterns with feature sizes ≤100 nm could direct stem cell fate or kill bacteria. These effects could be used to develop orthopedic implants with improved osseointegration and decreased chance of implant-associated infections. The quest for osteogenic and bactericidal nanopatterns is ongoing but no...journal article 2019
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Callens, S.J.P. (author), Tümer, N. (author), Zadpoor, A.A. (author)Origami-inspired folding methods present novel pathways to fabricate three-dimensional (3D) structures from 2D sheets. A key advantage of this approach is that planar printing and patterning processes could be used prior to folding, affording enhanced surface functionality to the folded structures. This is particularly useful for 3D lattices,...journal article 2019
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Hedayati, R. (author), Jedari Salami, S. (author), Li, Y. (author), Sadighi, M. (author), Zadpoor, A.A. (author)We study a special class of mechanical metamaterials, namely lattices, based on beams (struts) with nonuniform cross sections, of which pentamode mechanical metamaterials are a special case. Five symmetric beam types including simple cylinder, concave double cone, convex double cone, concave hyperbolic, and convex hyperbolic are considered....journal article 2019
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Janbaz, S. (author), Bobbert, F.S.L. (author), Mirzaali, Mohammad J. (author), Zadpoor, A.A. (author)Buckling, which was once considered the epitome of design failure, has been harnessed during the last few years to develop mechanical metamaterials with advanced functionalities. Soft robotics in general and soft actuators in particular could greatly benefit from such designer materials. Unlocking the great potential of buckling-driven...journal article 2019
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Ganjian, M. (author), Modaresifar, K. (author), Ligeon, Manon R.O. (author), Kunkels, Lorenzo B. (author), Tümer, N. (author), Angeloni, L. (author), Hagen, C.W. (author), Otten, L.G. (author), Hagedoorn, P.L. (author), Apachitei, I. (author), Fratila-Apachitei, E.L. (author), Zadpoor, A.A. (author)Development of synthetic bactericidal surfaces is a drug-free route to the prevention of implant-associated infections. Surface nanotopographies with specific dimensions have been shown to kill various types of bacterial strains through a mechanical mechanism, while regulating stem cell differentiation and tissue regeneration. The effective...journal article 2019
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Mirzaali, Mohammad J. (author), Pahlavani, H. (author), Zadpoor, A.A. (author)The emergence of advanced 3D printing techniques and the recent interest in architected materials have sparked a surge of interest in mechanical metamaterials whose unusual properties are defined by their highly ordered microarchitectures. Mechanical metamaterials with disordered microarchitectures have, however, not received as much...journal article 2019
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Tümer, N. (author), Vuurberg, Gwendolyn (author), Blankevoort, Leendert (author), Kerkhoffs, Gino M.M.J. (author), Tuijthof, G.J.M. (author), Zadpoor, A.A. (author)Bone shapes, particularly those defining the subtalar joint (STJ), have not received much attention yet as a risk factor for developing chronic ankle instability (CAI) after sustaining a lateral ankle sprain (LAS). This study aimed to compare three-dimensional (3D) shape variations in the STJ bones within individuals with CAI and healthy...journal article 2019
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Mirzaali, Mohammad J. (author), Herranz de la Nava, Alba (author), Gunashekar, Deepthishre (author), Nouri Goushki, M. (author), Doubrovski, E.L. (author), Zadpoor, A.A. (author)The functional gradient is a concept often occurring in nature. This concept can be implemented in the design and fabrication of advanced materials with specific functionalities and properties. Functionally graded materials (FGMs) can effectively eliminate the interface problems in extremely hard–soft connections, and, thus, have numerous and...journal article 2019