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Anderson, David M G (author), Kotnala, Ankita (author), Migas, L.G. (author), Patterson, N. Heath (author), Tideman, L.E.M. (author), Ach, Thomas (author), Tortorella, Sara (author), Van de Plas, Raf (author), Curcio, Christine A. (author), Schey, Kevin L. (author)Introduction: Age related macular degeneration (AMD) causes legal blindness worldwide, with few therapeutic targets in early disease and no treatments for 80% of cases. Extracellular deposits, including drusen and subretinal drusenoid deposits (SDD; also called reticular pseudodrusen), disrupt cone and rod photoreceptor functions and strongly...journal article 2023
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Sharman, Kavya (author), Patterson, Nathan Heath (author), Weiss, Andy (author), Neumann, Elizabeth K. (author), Guiberson, Emma R. (author), Ryan, Daniel J. (author), Gutierrez, Danielle B. (author), Spraggins, Jeffrey M. (author), Van de Plas, Raf (author), Skaar, Eric P. (author), Caprioli, Richard M. (author)Spatially targeted proteomics analyzes the proteome of specific cell types and functional regions within tissue. While spatial context is often essential to understanding biological processes, interpreting sub-region-specific protein profiles can pose a challenge due to the high-dimensional nature of the data. Here, we develop a multivariate...journal article 2023
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Esselman, Allison B. (author), Patterson, Nathan Heath (author), Migas, L.G. (author), Dufresne, Martin (author), Djambazova, Katerina V. (author), Colley, Madeline E. (author), Van de Plas, Raf (author), Spraggins, Jeffrey M. (author)The glomerulus is a multicellular functional tissue unit (FTU) of the nephron that is responsible for blood filtration. Each glomerulus contains multiple substructures and cell types that are crucial for their function. To understand normal aging and disease in kidneys, methods for high spatial resolution molecular imaging within these FTUs...journal article 2023
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Sharman, Kavya (author), Patterson, Nathan Heath (author), Migas, L.G. (author), Neumann, Elizabeth K. (author), Allen, Jamie (author), Gibson-Corley, Katherine N. (author), Spraggins, Jeffrey M. (author), Van de Plas, Raf (author), Skaar, Eric P. (author), Caprioli, Richard M. (author)Imaging mass spectrometry (IMS) provides untargeted, highly multiplexed maps of molecular distributions in tissue. Ion images are routinely presented as heatmaps and can be overlaid onto complementary microscopy images that provide greater context. However, heatmaps use transparency blending to visualize both images, obscuring subtle...journal article 2023
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Rahmani, S. (author), Baghbani, Asiye (author), Bouguila, Nizar (author), Patterson, Zachary (author)Graph neural networks (GNNs) have been extensively used in a wide variety of domains in recent years. Owing to their power in analyzing graph-structured data, they have become broadly popular in intelligent transportation systems (ITS) applications as well. Despite their widespread applications in different transportation domains, there is no...journal article 2023
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Tideman, L.E.M. (author), Migas, L.G. (author), Djambazova, Katerina V. (author), Patterson, Nathan Heath (author), Caprioli, Richard M. (author), Spraggins, Jeffrey M. (author), Van de Plas, Raf (author)The search for molecular species that are differentially expressed between biological states is an important step towards discovering promising biomarker candidates. In imaging mass spectrometry (IMS), performing this search manually is often impractical due to the large size and high-dimensionality of IMS datasets. Instead, we propose an...journal article 2021
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Neumann, Elizabeth K. (author), Patterson, Nathan Heath (author), Allen, Jamie L. (author), Migas, L.G. (author), Yang, Haichun (author), Brewer, Maya (author), Anderson, David M. (author), Harvey, Jennifer (author), Harris, Raymond C. (author), Van de Plas, Raf (author)Here, we describe the preservation and preparation of human kidney tissue for interrogation by histopathology, imaging mass spectrometry, and multiplexed immunofluorescence. Custom image registration and integration techniques are used to create cellular and molecular atlases of this organ system. Through careful optimization, we ensure high...journal article 2021
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Bohlin, G.A. (author), El Sioufy, Karim (author), Jainski, C. (author), Dreizler, A (author), Patterson, B.D. (author), Kliewer, C. J. (author)In practical combustion devices featuring high power densities, the interaction between flames and walls may have a significant impact on the thermodynamic efficiency and the formation of pollutants (e.g. unburned hydrocarbons and carbon monoxide). The common understanding is that at the region near the wall ~ 1 mm, where the solid metal surface...abstract 2019
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Bohlin, G.A. (author), El Sioufy, Karim (author), Jainski, C. (author), Patterson, B.D. (author), Dreizler, A (author), Kliewer, C. J. (author)In practical combustion-based devices, such as internal combustion (IC) engines and gas turbines for power generation, there exists significant interaction between gas-phase combustion and metal surfaces. The nature of this heterogeneous interaction is complex, involving both physical and chemical effects. The metal surface is generally much...abstract 2018
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Voicu, Cristiana (author), Mihai, Mara Madalina (author), Lupu, Mihai (author), Patterson, James W. (author), Koleva, Nely (author), Wollina, Uwe (author), Lotti, T. (author), Lotti, Jacopo (author), França, Katlein (author), Batashki, Atanas (author), Gianfaldoni, Serena (author), Bakardzhiev, Ilko (author), Mangarov, Hristo (author), Tchernev, Georgi (author)Background: Basal cell carcinoma (BCC) is the most frequently encountered neoplasm worldwide. While nodular BCC is the most frequent clinical subtype, other forms of BCC, such as superficial, cystic, morpheiform, infiltrative, and pigmented may also be encountered. CASE PRESENTATION: We present the case of a 67-year-old male with a relatively...journal article 2017
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Mihai, Mara Madalina (author), Voicu, Cristiana (author), Lupu, Mihai (author), Koleva, Nely (author), Patterson, James W. (author), Lotti, T. (author), Lotti, Jacopo (author), França, Katlein (author), Batashki, Atanas (author), Bakardzhiev, Ilko (author), Wollina, Uwe (author), Tchernev, Georgi (author)Background: Fibroepithelioma of Pinkus (FeP) is an uncommon and controversial skin lesion, sharing features of both basal cell carcinoma (BCC) and trichoepithelioma. In this article, we present a case of FeP and synthesise current concepts on the etiopathogenesis, diagnosis and treatment of this uncommon tumour. Case Report: We report the...review 2017
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Tebeica, Tiberiu (author), Voicu, Cristiana (author), Patterson, James W. (author), Mangarov, Hristo (author), Lotti, T. (author), Wollina, Uwe (author), Lotti, Jacopo (author), França, Katlein (author), Batashki, Atanas (author), Tchernev, Georgi (author)We report the case of a 42 years old male patient suffering from skin changes, which appeared in the last 7-8 years. Two biopsies were performed during the evolution of the lesion. Both showed similar findings that consisted in a busy dermis with interstitial, superficial and deep infiltrates of lymphocytes and histiocytes dispersed among...journal article 2017
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Tchernev, Georgi (author), Patterson, James W. (author), Bakardzhiev, Ilko (author), Lotti, T. (author), Lotti, Jacopo (author), França, Katlein (author), Batashki, Atanas (author), Wollina, Uwe (author)A 61-year-old woman, with a lifelong history of a giant congenital melanocytic nevus in the occipital region with secondary development of giant melanoma is presented. Surgical excision was performed, and the histopathological evaluation confirmed the diagnosis of Giant Malignant Melanoma (GMM) with a maximum tumour thickness of 16 mm....journal article 2017
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Gemmell, N.R. (author), McCarthy, A. (author), Liu, B. (author), Tanner, M.G. (author), Dorenbos, S.N. (author), Zwiller, V. (author), Patterson, M.S. (author), Buller, G.S. (author), Wilson, B.C. (author), Hadfield, R.H. (author)Direct monitoring of singlet oxygen (1O2) luminescence is a particularly challenging infrared photodetection problem. 1O2, an excited state of the oxygen molecule, is a crucial intermediate in many biological processes. We employ a low noise superconducting nanowire single-photon detector to record 1O2 luminescence at 1270 nm wavelength from a...journal article 2013
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- Patterson, G.N. (author) report 1986
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- Patterson, G.N. (author) report 1979
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- Patterson, G.N. (author) report 1977
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- Clarke, David (author), Patterson, D.R. (author), Wooderson, R.K. (author) report 1972
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New, L.D. (author), Patterson, B.I. (author)A test method for measuring the low temperature release time and the high temperature cup we ar preventive properties of air brake cylinder lubricants is described. The results of comparative trials of reference and various proprietary lubrlcants are given. Again, a non- soap thickened polyglycol grease containing MoS2 was best at 150°F. ...report 1966
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New, L.D. (author), Patterson, B.I. (author)The performance of AAR Specification 914 -42 and 914 - 62 and proprietary lubricants , in IQ - in. air brake cylinders, was compared at 150°F . and at - 50°F. A proprietary non- soap thickened polyglycol grease, containing MoS2, was best in endurance tests at 150° F. and in piston release time comparisons at - 50°F . AAR 914 -42 Specification...report 1965
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