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Kolovou Kouri, K. (author), Soloukey, Sadaf (author), Harhangi, Biswadjiet (author), Serdijn, W.A. (author), Giagka, Vasiliki (author)Spinal Cord Injury (SCI) is characterized by a disruption of the spinal pathways connecting the brain to the rest of the body. This can result in an impairment or complete loss of sensory and/or motor functions, depending on the level and severity of the injury. The most common approach of attempting motor recovery using neuromodulation has been...abstract 2021
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Coolen, R.L. (author), Emmer, K.M. (author), Spantidea, P.I. (author), Asselt, E. van (author), Scheepe, J.R. (author), Serdijn, W.A. (author), Blok, B.F.M. (author)Hoogfrequente stimulatie met bifasische blokpulsen in de kHz-range induceert een tijdelijke zenuwgeleidingsblokkade. Toegepast op de nervus pudendus, kan het de bekkenmusculatuur ontspannen. Dit kan helpen bij het legen van de blaas en de darmen, hetgeen een nieuwe therapie biedt voor urineretentie en disfunctionele defecatie. Deze studie is...journal article 2021
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Martins Da Ponte, R. (author), Gaio, N. (author), van Zeijl, H.W. (author), Vollebregt, S. (author), Dijkstra, Paul (author), Dekker, R. (author), Serdijn, W.A. (author), Giagka, Vasiliki (author)One of the many applications of organ-on-a-chip (OOC) technology is the study of biological processes in human induced pluripotent stem cells (iPSCs) during pharmacological drug screening. It is of paramount importance to construct OOCs equipped with highly compact in situ sensors that can accurately monitor, in real time, the extracellular...journal article 2021
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Celentano, A. (author), Pareschi, Fabio (author), Valente, V. (author), Rovatti, Riccardo (author), Serdijn, W.A. (author), Setti, Gianluca (author)We consider the design of Wireless Power Transfer (WPT) systems based on inductive links and focus on recent works where the whole WPT system (i.e. both energy transmitter and energy receiver) is designed as an isolated resonant class-E DC-DC converter characterized by a loosely-coupled transformer. The aim of this work is to compare the classic...conference paper 2021
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Kolovou Kouri, K. (author), Soloukey, Sadaf (author), Huygen, F.J.P.M. (author), Harhangi, Biswadjiet S. (author), Serdijn, W.A. (author), Giagka, Vasiliki (author)This paper presents the development of a Dorsal Root Ganglion (DRG) stimulator system intended for use in early clinical trials for motor recovery after Spinal Cord Injury (SCI). It allows for independent control of multisite/multilevel bilateral (on both sides of the spinal cord) stimulation, it can supply a high output current of 25.4mA,...conference paper 2021
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de Goederen, R. (author), Pu, S. (author), Silos Viu, M. (author), Doan, D. (author), Overeem, S. (author), Serdijn, W.A. (author), Joosten, K. F.M. (author), Long, X. (author), Dudink, J. (author)Study objectives: Unobtrusive monitoring of sleep and sleep disorders in children presents challenges. We investigated the possibility of using Ultra-Wide band (UWB) radar to measure sleep in children. Methods: Thirty-two children scheduled to undergo a clinical polysomnography participated; their ages ranged from 2 months to 14 years. During...journal article 2021
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Kandilakis, E. (author), Serdijn, W.A. (author), Akgün, O.C. (author)In this paper, we present the design of a low-voltage, low-power, and small-area time-mode ADC (TM-ADC) for bio-signal sensing applications. The proposed time-mode ADC (TM-ADC) consists of a programmable oversampling ratio (OSR), voltage-controlled ring oscillator (VCRO) based analog-to-time converter (ATC), followed by an asynchronous unfolded...conference paper 2021
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Akgün, O.C. (author), Nanbakhsh, K. (author), Giagka, Vasiliki (author), Serdijn, W.A. (author)For mm-sized implants incorporating silicon integrated circuits, ensuring lifetime operation of the chip within the corrosive environment of the body still remains a critical challenge. For the chip's packaging, various polymeric and thin ceramic coatings have been reported, demonstrating high biocompatibility and barrier properties. Yet, for...journal article 2020
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Nanbakhsh, K. (author), Ritasalo, R. (author), Serdijn, W.A. (author), Giagka, Vasiliki (author)In this work, we investigate the insulating performance of an atomic layer deposited (ALD) HfO2 - polymer bilayer for platinum (Pt) metallization. As test vehicles, Pt interdigitated comb structures (IDC) were designed and fabricated on SiO2/Si substrates. The IDCs were first coated with a 100 nm thin HfO2 ALD layer. A group of samples was...conference paper 2020
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Bakhshaee Babaroud, N. (author), Dekker, R. (author), Serdijn, W.A. (author), Giagka, Vasiliki (author)Parylene-C has been used as a substrate and encapsulation material for many implantable medical devices. However, to ensure the flexibility required in some applications, minimize tissue reaction, and protect parylene from degradation in vivo an additional outmost layer of polydimethylsiloxane (PDMS) is desired. In such a scenario, the adhesion...conference paper 2020
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Bakhshaee Babaroud, N. (author), Dekker, R. (author), Serdijn, W.A. (author), Giagka, Vasiliki (author)Parylene-C has been used as a substrate and encapsulation material for many implantable medical devices. However, to ensure the flexibility required in some applications, minimize tissue reaction, and protect parylene from degradation in vivo an additional outmost layer of polydimethylsiloxane (PDMS) is desired. In such a scenario, the...conference paper 2020
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Guan, R. (author), Zufiria, Pedro G. (author), Giagka, Vasiliki (author), Serdijn, W.A. (author)This paper presents the main circuit design considerations for power-efficient and safe implantable electrical neurostimulators. Related to medical applications, low-frequency (LF) stimulation for generating new action potentials and kilohertz-frequency alternating current (KHFAC) for blocking unwanted neural activity are introduced,...conference paper 2020
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Celentano, A. (author), Pareschi, Fabio (author), Valente, V. (author), Rovatti, Riccardo (author), Serdijn, W.A. (author), Setti, Gianluca (author)In this paper, the design of a wireless power transfer system (WPT) targeting biomedical implants is considered. The novelty of the approach is to propose a co-design of the transmitter and receiver side based on the design of class-E isolated DC-DC converters. The solution, along with the simple introduction of a shunt regulator at the...conference paper 2020
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Siddiqi, M.A. (author), Serdijn, W.A. (author), Strydis, C. (author)The wireless capabilities of modern Implantable Medical Devices (IMDs) make them vulnerable to security attacks. One prominent attack, which has disastrous consequences for the patient’s wellbeing, is the battery Denial-of-Service attack whereby the IMD is occupied with continuous authentication requests from an adversary with the aim of...journal article 2020
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Urso, A. (author), Chen, Y. (author), Staszewski, R.B. (author), Dijkhuis, Johan F. (author), Stanzione, Stefano (author), Liu, Y. (author), Serdijn, W.A. (author), Babaie, M. (author)In this paper, we propose a new scheme to directly power a 4.9-5.6GHz LC oscillator from a recursive switched-capacitor DC-DC converter. A finite-state machine is integrated to automatically adjust the conversion ratio and switching frequency of the converter such that its DC output voltage is within ±5% of the desired 1V across input voltage...journal article 2020
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Urso, A. (author), Chen, Y. (author), Dijkhuis, Johan F. (author), Liu, Yao-Hong (author), Babaie, M. (author), Serdijn, W.A. (author)This article presents guidelines for designing the power supply blocks of RF oscillators. To preserve their spectral purity, the requirements on the noise and ripple of the supply voltage are firstly evaluated based on the oscillator supply pushing factor and the oscillator Figure-of-Merit (FOM). Those specifications are then employed to design...journal article 2020
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Rout, S. (author), Babayan-Mashhadi, Samaneh (author), Serdijn, W.A. (author)Low-voltage and low-power front-end design is required for the safe and long-term monitoring of cardiac signals. To address the low-voltage challenge, this paper presents a subthreshold source-coupled logic (STSCL) based time-domain comparator designed in 180 nm CMOS process technology. At a low supply voltage of 0.8 V, the STSCL time-domain...conference paper 2019
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Akgün, O.C. (author), Nanbakhsh, K. (author), Giagka, Vasiliki (author), Serdijn, W.A. (author)One key obstacle in employing silicon integrated circuits in flexible implants is ensuring a long-term operation of the chip within the wet corrosive environment of the body. For this reason, throughout the years, various biocompatible insulating materials have been proposed, yet, evaluating their long-term encapsulation performance on...conference paper 2019
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Gancedo Reguilon, Alberto (author), Akgün, O.C. (author), Serdijn, W.A. (author)This paper presents the design of an extremely low-energy biosensing platform that utilizes voltage to time conversion and time-mode signal processing to sense and accommodate electrophysiological biosignals that will be later sent remotely using a simple and low power communication scheme. The electrode input is fed to a chain of monostable...conference paper 2019
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Das, Aurojyoti (author), Rout, S. (author), Urso, A. (author), Serdijn, W.A. (author)This paper presents a novel multichannel level-crossing (MLC) ADC architecture aimed at recording atrial electrograms from multiple channels. The proposed architecture combines synchronous sampling with level-crossing (LC) quantisation to achieve activity dependent operation while recording from multiple channels simultaneously. In the...conference paper 2019