Stochastic parcel tracking in an Euler–Lagrange compartment model for fast simulation of fermentation processes

The compartment model (CM) is a well-known approach for computationally affordable, spatially resolved hydrodynamic modeling of unit operations. Recent implementations use flow profiles based on Computational Fluid Dynamics (CFD) simulations, and several authors included microbial kinetics to simulate gradients in bioreactors. However, these...

Computational fluid dynamics simulation of an industrial P. chrysogenum fermentation with a coupled 9-pool metabolic model: Towards rational scale-down and design optimization

We assess the effect of substrate heterogeneity on the metabolic response of P. chrysogenum in industrial bioreactors via the coupling of a 9-pool metabolic model with Euler-Lagrange CFD simulations. In this work, we outline how this coupled hydrodynamic-metabolic modeling can be utilized in 5 steps. (1) A model response study with a fixed...

Euler-Lagrange computational fluid dynamics for (bio)reactor scale down: An analysis of organism lifelines

The trajectories, referred to as lifelines, of individual microorganisms in an industrial scale fermentor under substrate limiting conditions were studied using an Euler-Lagrange computational fluid dynamics approach. The metabolic response to substrate concentration variations along these lifelines provides deep insight in the dynamic...

A Practical Real Gas Model in CFD

Polynomial functions are generated to describe real gas properties in computational fluid dynamics (CFD). Two-variable relative least square fitting is applied. In this way the real gas model can be generated fast and easily and the computational time requested is small and precision of the function can be easily adjusted. In this paper this...