Dosimetric benefits and preclinical performance of steerable needles in HDR prostate brachytherapy

Prostate cancer patients with an enlarged prostate and/or excessive pubic arch interference (PAI) are generally considered non-eligible for high-dose-rate (HDR) brachytherapy (BT). Steerable needles have been developed to make these patients eligible again. This study aims to validate the dosimetric impact and performance of steerable needles...

MR-guided HDR prostate brachytherapy with teleoperated steerable needles

Conformity of tumour volumes and dose plans in prostate brachytherapy (BT) can be constrained by unwanted needle deflections, needle access restrictions and visualisation limitations. This work validates the feasibility of teleoperated robotic control of an active steerable needle using magnetic resonance (MR) for guidance. With this system,...

Axially rigid steerable needle with compliant active tip control

Steerable instruments allow for precise access to deeply-seated targets while sparing sensitive tissues and avoiding anatomical structures. In this study we present a novel omnidirectional steerable instrument for prostate high-dose-rate (HDR) brachytherapy (BT). The instrument utilizes a needle with internal compliant mechanism, which...

Dedicated holmium microsphere administration device for MRI-guided interstitial brain microbrachytherapy

Microbrachytherapy with radioactive holmium-166 (166Ho) microspheres (MS) has the potential to be an effective treatment method for brain malignancies. Direct intratumoural delivery of 166Ho-MS and dose coverage of the whole tumour are crucial requirements. However, currently no dedicated instruments for controlled intratumoural delivery...

LAPSI 2.0 thematic network: D2.1 Good practices collection on access to data

LAPSI 2.0 thematic network: D2.2 Position paper access to data

Faalkostenreductie door ketensamenwerking in de bouw

Faalkosten maken naar schatting circa 20 procent van de totale bouwkosten uit. Een groot gedeelte hiervan zijn structurele (te voorkomen) kosten. Door de onzekere (financiële) tijd wordt de druk op kostenverlaging en procesverbetering steeds groter om onderscheidend te zijn in de markt. Veel partijen hanteren in reactie hierop vooral een interne...

A property of algebraic univoque numbers

Consider the set U of real numbers q >= 1 for which only one sequence (c(i)) of integers 0 <= c(i) <= q satisfies the equality Sigma(infinity)(i= 1) ciq(-i) =1. We show that the set of algebraic numbers in U is dense in the closure (U) over bar of U.