- document
-
Wang, R. (author), Liu, Huanhuan (author), Antal, Bas (author), Wolterbeek, H.T. (author), Denkova, A.G. (author)The relatively high linear energy transfer of Auger electrons, which can cause clustered DNA damage and hence efficient cell death, makes Auger emitters excellent candidates for attacking metastasized tumors. Moreover, gammas or positrons are usually emitted along with the Auger electrons, providing the possibility of theragnostic...journal article 2024
- document
-
Ma, C. (author), Wolterbeek, H.T. (author), Denkova, A.G. (author), Serra Crespo, P. (author)Two porphyrinic metal-organic frameworks (PCN-222 and PCN-224) were prepared and their potential as molybdenum adsorbents for the <sup>99</sup>Mo/<sup>99m</sup>Tc generator was explored. The molybdenum adsorption properties of the two adsorbents, including adsorption kinetics and equilibrium isotherms, were evaluated at different molybdenum...journal article 2023
- document
-
Wang, R. (author), Ponsard, Bernard (author), Wolterbeek, H.T. (author), Denkova, A.G. (author)Background: Radionuclide therapy (RNT) has become a very important treatment modality for cancer nowadays. Comparing with other cancer treatment options, sufficient efficacy could be achieved in RNT with lower toxicity. β<sup>−</sup> emitters are frequently used in RNT due to the long tissue penetration depth of the β<sup>−</sup> particles....journal article 2022
- document
-
Ma, C. (author), Liu, H. (author), Wolterbeek, H.T. (author), Denkova, A.G. (author), Serra Crespo, P. (author)Four different MOFs were exposed to γrays by a cobalt-60 source reaching a maximum dose of 5 MGy. The results showed that the MIL-100 (Cr) and MIL-100 (Fe) did not exhibit obvious structural damage, suggesting their excellent radiation stability. MIL-101 (Cr) showed good radiation stability up to 4 MGy, but its structure started degrading...journal article 2022
- document
-
Ma, C. (author), Wolterbeek, H.T. (author), Denkova, A.G. (author), Serra Crespo, P. (author)The cerium-based metal–organic framework UiO-66 (Ce) was examined as a potential adsorbent for the <sup>99</sup>Mo/<sup>99m</sup>Tc generator. The results showed that the adsorbent had an outstanding adsorption performance, reaching up to 475 mg/g adsorption capacity at pH 3. An adsorption mechanism was proposed, where the adsorption was...journal article 2022
- document
-
Ma, C. (author), Vasileiadis, A. (author), Wolterbeek, H.T. (author), Denkova, A.G. (author), Serra Crespo, P. (author)The potential of the metal–organic framework UiO-66 and its functionalized derivatives for their utilization in the <sup>99</sup>Mo/<sup>99m</sup>Tc generator was assessed. Molybdenum adsorption experiments, structure characterization, molecular simulations and column experiments with molybdenum-99 were carried out. The results showed that...journal article 2021
- document
-
Tack, N. (author), Wamelink, G. W.W. (author), Denkova, A.G. (author), Schouwenburg, M. (author), Hilhorst, H. (author), Wolterbeek, H.T. (author), Goedhart, P. W. (author)The Martian surface is constantly exposed to a high dose of cosmic radiation consisting of highly energetic particles and multiple types of ionizing radiation. The dose can increase temporarily by a factor of 50 through the occurrence of highly energetic solar flares. This may affect crop growth in greenhouses on the Martian surface possibly...journal article 2021
- document
-
Bhardwaj, R. (author), Wolterbeek, H.T. (author), Denkova, A.G. (author), Serra Crespo, P. (author)A solid phase extraction based <sup>177m</sup>Lu-<sup>177</sup>Lu separation method has been investigated for its feasibility to be used in the radionuclide generator. The use of 2,2′,2”-(10-(2,6-dioxotetrahydro-2H-pyran-3-yl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic acid, (DOTAGA-anhydride) allowed grafting of DOTA (1,4,7,10...journal article 2020
- document
-
Moret, J.L.T.M. (author), Griffiths, Matthew B.E. (author), Frijns, Jeannine E.B.M. (author), Terpstra, B.E. (author), Wolterbeek, H.T. (author), Barry, Seán T. (author), Denkova, A.G. (author), van Ommen, J.R. (author)Atomic layer deposition (ALD) is a versatile gas phase coating technique that allows coating of complex structured materials, as well as high-surface area materials such as nanoparticles. In this work, ALD is used to deposit a lutetium oxide layer on TiO<sub>2</sub> nanoparticles (P25) in a fluidized bed reactor to produce particles for...journal article 2020
- document
-
Moret, J. L.T.M. (author), Alkemade, J. (author), Upcraft, T. M. (author), Paulssen, E. (author), Wolterbeek, H.T. (author), van Ommen, J.R. (author), Denkova, A.G. (author)New production routes for <sup>99</sup>Mo are steadily gaining importance. However, the obtained specific activity is much lower than currently produced by the fission of U-235. To be able to supply hospitals with <sup>99</sup>Mo/<sup>99m</sup>Tc generators with the desired activity, the adsorption capacity of the column material should be...journal article 2020
- document
-
Moret, J.L.T.M. (author), Hardens, T. A. (author), van Batenburg, O. (author), Wolterbeek, H.T. (author), van Ommen, J.R. (author), Denkova, A.G. (author)Cu is an important trace metal which plays a role in many biological processes. The radioisotope <sup>64</sup>Cu is often used to study such processes. Furthermore, <sup>64</sup>Cu finds applications in cancer diagnostics as well as therapy. For all of these applications <sup>64</sup>Cu having high specific activity is needed. <sup>64</sup>Cu...journal article 2020
- document
-
Markert, B (author), Abdallah, N. (author), Aksoy, A. (author), Ammari, T. (author), Arias, A (author), Azaizeh, H. (author), Badran, A. (author), Baltrėnaitė, E. (author), Wolterbeek, H.T. (author)Different definitions for the concepts of information, information transfer, i.e. communication and its effect and efficiency of false, but also correct information, especially from the environmental sector, are given. "THE TEN ECOLOGICAL COMMANDMENTS"developed by Menke-Glückert at the end of the 1960s, the 9th commandment "Do not pollute...review 2020
- document
-
Bhardwaj, R. (author), Wolterbeek, H.T. (author), Denkova, A.G. (author), Serra Crespo, P. (author)In order to determine the potential of <sup>177m</sup>Lu/<sup>177</sup>Lu radionuclide generator in <sup>177</sup>Lu production it is important to establish the technical needs that can lead to a clinically acceptable <sup>177</sup>Lu product quality. In this work, a model that includes all the processes and the parameters affecting the...journal article 2020
- document
-
Bhardwaj, R. (author), Wolterbeek, H.T. (author), Denkova, A.G. (author), Serra Crespo, P. (author)Background In this work, a lutetium-177 (177Lu) production method based on the separation of nuclear isomers, 177mLu & 177Lu, is reported. The 177mLu-177Lu separation is performed by combining the use of DOTA & DOTA-labelled peptide (DOTATATE) and liquid-liquid extraction. Methods The 177mLu cations were complexed with DOTA &...journal article 2019
- document
-
Kouwenberg, J.J.M. (author), Wolterbeek, H.T. (author), Denkova, A.G. (author), bos, A.J.J. (author)Background: While alpha microdosimetry dates back a couple of decades, the effects of localized energy deposition of alpha particles are often still unclear since few comparative studies have been performed. Most modern alpha microdosimetry studies rely for large parts on simulations, which negatively impacts both the simplicity of the...journal article 2018
- document
-
Kouwenberg, J.J.M. (author), Kremers, G. J. (author), Slotman, J. A. (author), Wolterbeek, H.T. (author), Houtsmuller, A.B. (author), Denkova, A.G. (author), bos, A.J.J. (author)Structured illumination microscopy (SIM) for the imaging of alpha particle tracks in fluorescent nuclear track detectors (FNTD) was evaluated and compared to confocal laser scanning microscopy (CLSM). FNTDs were irradiated with an external alpha source and imaged using both methodologies. SIM imaging resulted in improved resolution, without...journal article 2018
- document
-
Smetsers, R.C.G.M. (author), Wolterbeek, H.T. (author), van Gelder, P.H.A.J.M. (author), Huitema, K.R. (author), van Zalen, Ed (author)In a report issued in 2008, the Health Council of the Netherlands noted that the scientific knowledge on radiation protection was seriously in decline. This statement is still valid nowadays. It is therefore important to collate existing radiation knowledge, to make state-of-the-art expertise available to government and society and to acquire...report 2018
- document
-
Kouwenberg, J.J.M. (author), de Pooter, J. A. (author), Wolterbeek, H.T. (author), Denkova, A.G. (author), bos, A.J.J. (author)To answer the need for better tools for alpha radiation radiobiology and microdosimetry research, a novel irradiation setup based on a honeycomb collimator, in combination with Fluorescent Nuclear Track Detectors (FNTD) for alpha radiation dosimetry and spectroscopy, was introduced. FNTDs are a novel type of small, crystalline detector that...journal article 2018
- document
-
Yagob Mohamed, T.I. (author), Bode, P. (author), van de Wiel, A. (author), Ismail, Fadwa (author), Wolterbeek, H.T. (author)Iron deficiency anaemia is a major health problem worldwide, but may be complicated in underdeveloped nations by deficiencies of other micronutrients with consequences for adequate treatment. The World Health Organization (WHO) estimates that 2 billion people – over 30% of the world’s population – are anaemic, approximately 50% of cases of...journal article 2017
- document
-
Bhardwaj, R. (author), van der Meer, A.J.G.M. (author), Das, S.K. (author), de Bruin, M (author), Gascon, Jorge (author), Wolterbeek, H.T. (author), Denkova, A.G. (author), Serra Crespo, P. (author)177Lu has sprung as a promising radionuclide for targeted therapy. The low soft tissue penetration of its β− emission results in very efficient energy deposition in small-size tumours. Because of this, 177Lu is used in the treatment of neuroendocrine tumours and is also clinically approved for prostate cancer therapy. In this work, we report a...journal article 2017