Searched for: author%3A%22van+Osch%2C+G.J.V.M.%22
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Kalogeropoulou, Maria (author), Diaz Payno, P.J. (author), Mirzaali, Mohammad J. (author), van Osch, G.J.V.M. (author), Fratila-Apachitei, E.L. (author), Zadpoor, A.A. (author)
The existing 3D printing methods exhibit certain fabrication-dependent limitations for printing curved constructs that are relevant for many tissues. Four-dimensional (4D) printing is an emerging technology that is expected to revolutionize the field of tissue engineering and regenerative medicine (TERM). 4D printing is based on 3D printing,...
review 2024
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Xu, J. (author), Vecstaudza, Jana (author), Wesdorp, Marinus A. (author), Labberté, Margot (author), Salerno, Manuela (author), Kok, Joeri (author), van Rietbergen, Bert (author), van Osch, G.J.V.M. (author), Locs, Janis (author), Brama, Pieter A.J. (author)
Osteochondral defect repair with a collagen/collagen-magnesium-hydroxyapatite (Col/Col-Mg-HAp) scaffold has demonstrated good clinical results. However, subchondral bone repair remained suboptimal, potentially leading to damage to the regenerated overlying neocartilage. This study aimed to improve the bone repair potential of this scaffold by...
journal article 2024
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Pitta Kruize, Carlos (author), Panahkhahi, S. (author), Putra, N.E. (author), Diaz Payno, P.J. (author), van Osch, G.J.V.M. (author), Zadpoor, A.A. (author), Mirzaali, Mohammad J. (author)
Bone-to-soft tissue interfaces are responsible for transferring loads between tissues with significantly dissimilar material properties. The examples of connective soft tissues are ligaments, tendons, and cartilages. Such natural tissue interfaces have unique microstructural properties and characteristics which avoid the abrupt transitions...
review 2023
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Xu, J. (author), Fahmy-Garcia, Shorouk (author), Wesdorp, Marinus A. (author), Forte, Lucia (author), De Luca, Claudio (author), Filardo, Giuseppe (author), Labberté, Margot (author), Kok, Joeri (author), Nickel, Joachim (author), van Osch, G.J.V.M. (author)
Despite promising clinical results in osteochondral defect repair, a recently developed bi-layered collagen/collagen-magnesium-hydroxyapatite scaffold has demonstrated less optimal subchondral bone repair. This study aimed to improve the bone repair potential of this scaffold by adsorbing bone morphogenetic protein 2 (BMP-2) and/or platelet...
journal article 2023
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Zhou, Liangbin (author), Xu, J. (author), Schwab, Andrea (author), Tong, Wenxue (author), Zheng, Lizhen (author), Li, Zhuo (author), Xu, Shunxiang (author), van Osch, G.J.V.M. (author), Wen, Chunyi (author), Qin, Ling (author)
As a highly specialized shock-absorbing connective tissue, articular cartilage (AC) has very limited self-repair capacity after traumatic injuries, posing a heavy socioeconomic burden. Common clinical therapies for small- to medium-size focal AC defects are well-developed endogenous repair and cell-based strategies, including microfracture,...
review 2023
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Ji, Encheng (author), Leijsten, Lieke (author), Witte-Bouma, Janneke (author), Rouchon, Adelin (author), Di Maggio, Nunzia (author), Banfi, Andrea (author), van Osch, G.J.V.M. (author), Farrell, Eric (author), Lolli, Andrea (author)
Tissue engineering bone via endochondral ossification requires the generation of a cartilage template which undergoes vascularisation and remodelling. While this is a promising route for bone repair, achieving effective cartilage vascularisation remains a challenge. Here, we investigated how mineralisation of tissue-engineered cartilage...
journal article 2023
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Velot, Émilie (author), Balmayor, Elizabeth R. (author), Bertoni, Lélia (author), Chubinskaya, Susan (author), Cicuttini, Flavia (author), de Girolamo, Laura (author), Demoor, Magali (author), van Osch, G.J.V.M. (author), Cucchiarini, Magali (author)
review 2023
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Cruz Saldivar, M. (author), Veeger, Robin Petrus Elias (author), Tay, E.T.W.S. (author), Fenu, M. (author), Klimopoulou, M. (author), van Osch, G.J.V.M. (author), Fratila-Apachitei, E.L. (author), Doubrovski, E.L. (author), Mirzaali, Mohammad J. (author), Zadpoor, A.A. (author)
Living organisms use functional gradients (FGs) to interface hard and soft materials (e.g., bone and tendon), a strategy with engineering potential. Past attempts involving hard (or soft) phase ratio variation have led to mechanical property inaccuracies because of microscale-material macroscale-property nonlinearity. This study examines 3D...
journal article 2023
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Siverino, Claudia (author), Fahmy-Garcia, Shorouk (author), Niklaus, Viktoria (author), Kops, Nicole (author), Dolcini, Laura (author), Misciagna, Massimiliano Maraglino (author), Ridwan, Yanto (author), Farrell, Eric (author), van Osch, G.J.V.M. (author), Nickel, Joachim (author)
Bone Morphogenetic proteins (BMPs) like BMP2 and BMP7 have shown great potential in the treatment of severe bone defects. In recent in vitro studies, BMP9 revealed the highest osteogenic potential compared to other BMPs, possibly due to its unique signaling pathways that differs from other osteogenic BMPs. However, in vivo the bone forming...
journal article 2023
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Voskamp, Chantal (author), Koevoet, Wendy J.L.M. (author), van Osch, G.J.V.M. (author), Narcisi, Roberto (author)
Introduction: Mesenchymal stromal/progenitor cells (MSCs) are promising for cartilage cell-based therapies due to their chondrogenic differentiation capacity. However, MSCs can become senescent during in vitro expansion, a state characterized by stable cell cycle arrest, metabolic alterations, and substantial changes in the gene expression and...
journal article 2023
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Schwab, Andrea (author), Wesdorp, Marinus A. (author), Xu, J. (author), Abinzano, Florencia (author), Loebel, Claudia (author), Levato, Riccardo (author), Eglin, David (author), Narcisi, Roberto (author), Malda, Jos (author), van Osch, G.J.V.M. (author)
Background: The use of acellular hydrogels to repair osteochondral defects requires cells to first invade the biomaterial and then to deposit extracellular matrix for tissue regeneration. Due to the diverse physicochemical properties of engineered hydrogels, the specific properties that allow or even improve the behaviour of cells are not yet...
journal article 2023
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Pagani, Stefania (author), Salerno, Manuela (author), Filardo, Giuseppe (author), Locs, Janis (author), van Osch, G.J.V.M. (author), Vecstaudza, Jana (author), Dolcini, Laura (author), Borsari, Veronica (author), Fini, Milena (author), Giavaresi, Gianluca (author), Columbaro, Marta (author)
Osteochondral lesions, when not properly treated, may evolve into osteoarthritis (OA), especially in the elderly population, where altered joint function and quality are usual. To date, a collagen/collagen–magnesium–hydroxyapatite (Col/Col-Mg-HAp) scaffold (OC) has demonstrated good clinical results, although suboptimal subchondral bone...
journal article 2023
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Wesdorp, Marinus A. (author), Schwab, Andrea (author), Bektas, Ezgi Irem (author), Narcisi, Roberto (author), Eglin, David (author), Stoddart, Martin J. (author), van Osch, G.J.V.M. (author), D'Este, Matteo (author)
Neutrophils play a pivotal role in orchestrating the immune system response to biomaterials, the onset and resolution of chronic inflammation, and macrophage polarization. However, the neutrophil response to biomaterials and the consequent impact on tissue engineering approaches is still scarcely understood. Here, we report an in vitro...
journal article 2023
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Muntz, I.A.A. (author), Fenu, M. (author), van Osch, G.J.V.M. (author), Koenderink, G.H. (author)
Living tissue is able to withstand large stresses in everyday life, yet it also actively adapts to dynamic loads. This remarkable mechanical behaviour emerges from the interplay between living cells and their non-living extracellular environment. Here we review recent insights into the biophysical mechanisms involved in the reciprocal...
review 2022
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Ferrao Blanco, Mauricio N. (author), Bastiaansen Jenniskens, Yvonne M. (author), Kops, Nicole (author), Chavli, Athina (author), Narcisi, Roberto (author), Botter, Sander M. (author), Leenen, P.J.M. (author), van Osch, G.J.V.M. (author), Fahy, Niamh (author)
Background and purpose: Corticosteroids such as triamcinolone acetonide (TAA) are potent drugs administered intra-articularly as an anti-inflammatory therapy to relieve pain associated with osteoarthritis (OA). However, the ability of early TAA intervention to mitigate OA progression and modulate immune cell subsets remains unclear. Here, we...
journal article 2022
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Wesdorp, Marinus A. (author), Capar, Serdar (author), Bastiaansen-Jenniskens, Yvonne M. (author), Kops, Nicole (author), Creemers, Laura B. (author), Verhaar, Jan A.N. (author), van Osch, G.J.V.M. (author), Wei, Wu (author)
Background: Cartilage defects result in joint inflammation. The presence of proinflammatory factors has been described to negatively affect cartilage formation. Purpose: To evaluate the effect and timing of administration of triamcinolone acetonide (TAA), an anti-inflammatory drug, on cartilage repair using a mouse model. Study Design:...
journal article 2022
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Lesage, Raphaëlle (author), Ferrao Blanco, Mauricio N. (author), Narcisi, Roberto (author), Welting, Tim (author), van Osch, G.J.V.M. (author), Geris, Liesbet (author)
Background: Without the availability of disease-modifying drugs, there is an unmet therapeutic need for osteoarthritic patients. During osteoarthritis, the homeostasis of articular chondrocytes is dysregulated and a phenotypical transition called hypertrophy occurs, leading to cartilage degeneration. Targeting this phenotypic transition has...
journal article 2022
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Diaz Payno, P.J. (author), Kalogeropoulou, Maria (author), Muntz, I.A.A. (author), Kingma, Esther (author), Kops, Nicole (author), D'Este, Matteo (author), Koenderink, G.H. (author), Fratila-Apachitei, E.L. (author), van Osch, G.J.V.M. (author), Zadpoor, A.A. (author)
3D bioprinting is usually implemented on flat surfaces, posing serious limitations in the fabrication of multilayered curved constructs. 4D bioprinting, combining 3D bioprinting with time-dependent stimuli-induced transformation, enables the fabrication of shape-changing constructs. Here, a 4D biofabrication method is reported for cartilage...
journal article 2022
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Wesdorp, Marinus A. (author), Bastiaansen-Jenniskens, Yvonne M. (author), Capar, Serdar (author), Verhaar, Jan A.N. (author), Narcisi, R. (author), van Osch, G.J.V.M. (author)
OBJECTIVE: Inflammation is known to negatively affect cartilage repair. However, it is unclear how inflammation influences the migration of mesenchymal stromal cells (MSCs) from the underlying bone marrow into the defect. We therefore aimed to investigate how synovial inflammation influences MSC migration, and whether modulation of...
journal article 2022
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Zhou, Liangbin (author), Guo, Peng (author), D'Este, Matteo (author), Tong, Wenxue (author), Xu, Jiankun (author), Yao, Hao (author), Stoddart, Martin J. (author), van Osch, G.J.V.M. (author), Ho, Kevin Ki Wai (author), Li, Zhen (author), Qin, Ling (author)
Articular cartilage (AC) is an avascular and flexible connective tissue located on the bone surface in the diarthrodial joints. AC defects are common in the knees of young and physically active individuals. Because of the lack of suitable tissue-engineered artificial matrices, current therapies for AC defects, especially full-thickness AC...
review 2022
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