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Towards reusable building blocks for agent-based modelling and theory development

Berger, Uta (author), Bell, Andrew (author), Barton, C. Michael (author), Chappin, E.J.L. (author), Dreßler, Gunnar (author), Filatova, T. (author), Fronville, Thibault (author), Lee, Allen (author), van Loon, Emiel (author), Lorscheid, Iris (author), Meyer, Matthias (author), Müller, Birgit (author), Piou, Cyril (author), Radchuk, Viktoriia (author), Roxburgh, Nicholas (author), Schüler, Lennart (author), Troost, Christian (author), Wijermans, Nanda (author), Williams, Tim G. (author), Wimmler, Marie Christin (author), Grimm, Volker (author)

Despite the increasing use of standards for documenting and testing agent-based models (ABMs) and sharing of open access code, most ABMs are still developed from scratch. This is not only inefficient, but also leads to ad hoc and often inconsistent implementations of the same theories in computational code and delays progress in the...

journal article 2024

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Statistical Analysis of SARS-CoV-2 Using Wastewater-Based Data of Stockholm, Sweden

Chekkala, Aashlesha (author), Atasoy, M. (author), Williams, Cecilia (author), Cetecioglu, Zeynep (author)

An approach based on wastewater epidemiology can be used to monitor the COVID-19 pandemic by assessing the gene copy number of SARS-CoV-2 in wastewater. In the present study, we statistically analyzed such data from six inlets of three wastewater treatment plants, covering six regions of Stockholm, Sweden, collected over an approximate year...

journal article 2023

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A flexible micro-randomized trial design and sample size considerations

Xu, Jing (author), Yan, Xiaoxi (author), Figueroa, C.A. (author), Williams, Joseph Jay (author), Chakraborty, Bibhas (author)

Technological advancements have made it possible to deliver mobile health interventions to individuals. A novel framework that has emerged from such advancements is the just-in-time adaptive intervention, which aims to suggest the right support to the individuals when their needs arise. The micro-randomized trial design has been proposed...

journal article 2023

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Ratings and experiences in using a mobile application to increase physical activity among university students: implications for future design

Figueroa, C.A. (author), Gomez-Pathak, Laura (author), Khan, Imran (author), Williams, Joseph Jay (author), Lyles, Courtney R. (author), Aguilera, Adrian (author)

University students have low levels of physical activity and are at risk of mental health disorders. Mobile apps to encourage physical activity can help students, who are frequent smartphone-users, to improve their physical and mental health. Here we report students’ qualitative feedback on a physical activity smartphone app with motivational...

journal article 2023

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Using normalised difference infrared index patterns to constrain semi-distributed rainfall–runoff models in tropical nested catchments

Sriwongsitanon, Nutchanart (author), Jandang, Wasana (author), Williams, James (author), Suwawong, Thienchart (author), Maekan, Ekkarin (author), Savenije, Hubert (author)

A parsimonious semi-distributed rainfall–runoff model has been developed for flow prediction. In distribution, attention is paid to both the timing of the runoff and the heterogeneity of moisture storage capacities within sub-catchments. This model is based on the lumped FLEXL model structure, which has proven its value in a wide range of...

journal article 2023

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The potential impact of human interventions at different scales in offshore wind farms to promote flat oyster (Ostrea edulis) reef development in the southern North Sea

ter Hofstede, R. (author), Williams, Gregory (author), van Koningsveld, M. (author)

Incorporation of ecology and ecosystem services into marine infrastructural developments has gained interest over the last decades. Growing attention is given to combine the massive roll-out of offshore wind farms in the North Sea with reinstating the once rich but nowadays nearly extinct European flat oyster (Ostrea edulis). However, the...

journal article 2023

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Developing a pan-European high-resolution groundwater recharge map – Combining satellite data and national survey data using machine learning

Martinsen, Grith (author), Bessiere, Helene (author), Caballero, Yvan (author), Koch, Julian (author), Collados-Lara, Antonio Juan (author), Mansour, Majdi (author), Sallasmaa, Olli (author), Pulido-Velazquez, David (author), Williams, Natalya Hunter (author), Zaadnoordijk, Willem (author), Stisen, Simon (author)

Groundwater recharge quantification is essential for sustainable groundwater resources management, but typically limited to local and regional scale estimates. A high-resolution (1 km × 1 km) dataset consisting of long-term average actual evapotranspiration, effective precipitation, a groundwater recharge coefficient, and the resulting...

journal article 2022

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High-resolution reconstruction of a Jumbo-bacteriophage infecting capsulated bacteria using hyperbranched tail fibers

Ouyang, Ruochen (author), Martins Costa, A.R. (author), Cassidy, C. Keith (author), Otwinowska, Aleksandra (author), Williams, Vera C.J. (author), Latka, Agnieszka (author), Stansfeld, Phill J. (author), Drulis-Kawa, Zuzanna (author), Brouns, S.J.J. (author)

The Klebsiella jumbo myophage ϕKp24 displays an unusually complex arrangement of tail fibers interacting with a host cell. In this study, we combine cryo-electron microscopy methods, protein structure prediction methods, molecular simulations, microbiological and machine learning approaches to explore the capsid, tail, and tail fibers of...

journal article 2022

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A spatially resolved brain region- and cell type-specific isoform atlas of the postnatal mouse brain

Joglekar, Anoushka (author), Prjibelski, Andreyi (author), Mahfouz, A.M.E.T.A. (author), Collier, Paul (author), Lin, Susan (author), Schlusche, Anna Katharina (author), Marrocco, Jordan (author), Williams, Stephen R. (author), Haase, Bettina (author)

Splicing varies across brain regions, but the single-cell resolution of regional variation is unclear. We present a single-cell investigation of differential isoform expression (DIE) between brain regions using single-cell long-read sequencing in mouse hippocampus and prefrontal cortex in 45 cell types at postnatal day 7 (www.isoformAtlas.com...

journal article 2021

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Knickpoints and crescentic bedform interactions in submarine channels

Chen, Ye (author), Parsons, Daniel R. (author), Simmons, Stephen M. (author), Williams, Rebecca (author), Cartigny, Matthieu J.B. (author), Hughes Clarke, John E. (author), Stacey, Cooper D. (author), Hage, Sophie (author), Azpiroz Zabala, M. (author)

Submarine channels deliver globally important volumes of sediments, nutrients, contaminants and organic carbon into the deep sea. Knickpoints are significant topographic features found within numerous submarine channels, which most likely play an important role in channel evolution and the behaviour of the submarine sediment-laden flows ...

journal article 2021

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Compartmentalized cross-linked enzymatic nano -aggregates (c -CLE n A) for efficient in-flow biocatalysis

De Martino, M. Teresa (author), Tonin, F. (author), Yewdall, N. Amy (author), Abdelghani, Mona (author), Williams, David S. (author), Hanefeld, U. (author), Rutjes, Floris P.J.T. (author), Abdelmohsen, Loai K.E.A. (author), Van Hest, Jan C.M. (author)

Nano-sized enzyme aggregates, which preserve their catalytic activity are of great interest for flow processes, as these catalytic species show minimal diffusional issues, and are still sizeable enough to be effectively separated from the formed product. The realization of such catalysts is however far from trivial. The stable formation of a...

journal article 2020

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4D objects-by-change: Spatiotemporal segmentation of geomorphic surface change from LiDAR time series

Anders, K.P. (author), Winiwarter, Lukas (author), Lindenbergh, R.C. (author), Williams, Jack G. (author), Vos, S.E. (author), Höfle, Bernhard (author)

Time series of topographic data are becoming increasingly widespread for monitoring geomorphic activity. Dense 3D time series are now obtained by near-continuous terrestrial laser scanning (TLS) installations, which acquire data at high frequency (e.g. hourly) and over long periods. Such datasets contain valuable information on topographic...

journal article 2020

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Slow Electron-Phonon Cooling in Superconducting Diamond Films

Titova, Nadezhda (author), Kardakova, Anna I. (author), Tovpeko, Nina (author), Ryabchun, Sergey (author), Mandal, Soumen (author), Morozov, Dmitry (author), Klemencic, Georgina M. (author), Giblin, Sean R. (author), Williams, Oliver A. (author), Goltsman, Gregory N. (author), Klapwijk, T.M. (author)

We have measured the electron-phonon energy-relaxation time, τ_eph, in superconducting boron-doped diamond films grown on silicon substrate by chemical vapor deposition. The observed electron-phonon cooling times vary from 160 ns at 2.70 K to 410 ns at 1.8 K following a T^-2-dependence. The data are consistent with the...

journal article 2017

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An empirical validation of a unified model of electronic government adoption (UMEGA)

Dwivedi, Yogesh K. (author), Rana, Nripendra P. (author), Janssen, M.F.W.H.A. (author), Lal, Banita (author), Williams, Michael D. (author), Clement, Marc (author)

In electronic government (hereafter e-government), a large variety of technology adoption models are employed, which make researchers and policymakers puzzled about which one to use. In this research, nine well-known theoretical models of information technology adoption are evaluated and 29 different constructs are identified. A unified model...

journal article 2017

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The imaginary worlds of sustainability: Observations from an interactive art installation

Bendor, R. (author), Maggs, David (author), Peake, Rachel (author), Robinson, John (author), Williams, Steve (author)

We report on preliminary results from a public engagement project based on a procedural approach to sustainability. The project centered on an interactive art installation that comprised a live actor, an immersive soundscape featuring a handful of different characters, an interactive touch-table, and four interactive rooms within which...

journal article 2017

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Genomic Determinants of Protein Abundance Variation in Colorectal Cancer Cells

Roumeliotis, Theodoros I. (author), Williams, Steven P. (author), Gonçalves, Emanuel (author), Alsinet, Clara (author), Del Castillo Velasco-Herrera, Martin (author), Aben, N.N. (author), Zamanzad Ghavidel, Fatemeh (author), Michaut, Magali (author), Schubert, Michael (author), Price, Stacey (author), Wessels, L.F.A. (author)

Assessing the impact of genomic alterations on protein networks is fundamental in identifying the mechanisms that shape cancer heterogeneity. We have used isobaric labeling to characterize the proteomic landscapes of 50 colorectal cancer cell lines and to decipher the functional consequences of somatic genomic variants. The robust...

journal article 2017

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Novel widely tunable monolithically integrated laser source

Latkowski, S. (author), Hansel, A. (author), Bhattacharya, N. (author), De Vries, T. (author), Augustin, L. (author), Williams, K. (author), Smit, M. (author), Bente, E. (author)

journal article 2015

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The spatial-temporal variability of air-sea momentum fluxes observed at a tidal inlet

Ortiz-Suslow, D.G. (author), Haus, B.K. (author), Williams, N.J. (author), Laxague, N.J.M. (author), Reniers, A.J.H.M. (author), Graber, H.C. (author)

Coastal waters are an aerodynamically unique environment that has been little explored from an air-sea interaction point of view. Consequently, most studies must assume that open ocean-derived parameterizations of the air-sea momentum flux are representative of the nearshore wind forcing. Observations made at the New River Inlet in North...

journal article 2015

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Widespread low rates of Antarctic glacial isostatic adjustment revealed by GPS observations

Thomas, I.D. (author), King, M.A. (author), Bentley, M.J. (author), Whitehouse, P.L. (author), Penna, N.T. (author), Williams, S.D.P. (author), Riva, R.E.M. (author), Lavallee, D.A. (author), Clarke, P.J. (author), King, E.C. (author), Hindmarch, R.C.A. (author), Koivula, H. (author)

Bedrock uplift in Antarctica is dominated by a combination of glacial isostatic adjustment (GIA) and elastic response to contemporary mass change. Here, we present spatially extensive GPS observations of Antarctic bedrock uplift, using 52% more stations than previous studies, giving enhanced coverage, and with improved precision. We observe...

journal article 2011

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Terahertz heterodyne spectrometer using a quantum cascade laser

Ren, Y. (author), Hovenier, J.N. (author), Higgins, R. (author), Gao, J.R. (author), Klapwijk, T.M. (author), Shi, S.C. (author), Bell, A. (author), Klein, B. (author), Williams, B.S. (author), Kumar, S. (author), Hu, Q. (author), Reno, J.L. (author)

A terahertz (THz) heterodyne spectrometer is demonstrated based on a quantum cascade laser (QCL) as a local oscillator (LO) and an NbN hot electron bolometer as a mixer, and it is used to measure high-resolution molecular spectral lines of methanol (CH3OH) between 2.913–2.918 THz. The spectral lines are taken from a gas cell containing methanol...

journal article 2010