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When transcriptome meets metabolome: Fast cellular responses of yeast to sudden relief of glucose limitation

Heijnen, J.J. (author), Daran, J.M. (author), Pronk, J.T. (author), Daran-Lapujade, P. (author), Knijnenburg, T.A. (author), Ras, C. (author), Ten Pierick, A. (author), Akmering, M.J. (author), Van Winden, W.A. (author), Kresnowati, M.T. (author)

Within the first 5 min after a sudden relief from glucose limitation, Saccharomyces cerevisiae exhibited fast changes of intracellular metabolite levels and a major transcriptional reprogramming. Integration of transcriptome and metabolome data revealed tight relationships between the changes at these two levels. Transcriptome as well as...

journal article 2006

document

Metabolic engineering of xylose fermenting eukaryotic cells

Winkler, A.A. (author), Kuyper, S.M. (author), De Laat, W.T. (author), Van Dijken, J.P. (author), Pronk, J.T. (author)

The present invention relates to further genetic modifications in eukaryotic host cells that have been transformed to express a xylose isomerase that confers the host cell the ability of isomerising xylose to xylulose. The further genetic modifications are aimed at improving the efficiency of xylose metabolism and include e.g. reduction of...

patent 2006

document

Industrial Biotechnology: Drive my car

Pronk, J.T (author)

Dies Natalis 164

public lecture 2006

document

Carbonic anhydrase (Nce103p): An essential biosynthetic enzyme for growth of Saccharomyces cerevisiae at atmospheric carbon dioxide pressure

Aguilera, J. (author), Van Dijken, J.P. (author), De Winde, J.H. (author), Pronk, J.T. (author)

journal article 2005

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Prolonged selection in aerobic, glucose-limited chemostat cultures of Saccharomyces cerevisiae causes a partial loss of glycolytic capacity

Jansen, M.L.A. (author), Diderich, J.A. (author), Mashego, M. (author), Hassane, A. (author), de Winde, J.H. (author), Daran-Lapujade, P. (author), Pronk, J.T. (author)

journal article 2005

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Physiological Characterization of the ARO10-Dependent, Broad-Substrate-Specificity 2-Oxo Acid Decarboxylase Activity of Saccharomyces cerevisiae

Vuralhan, Z. (author), Luttik, M.A. (author), Tai, S.L. (author), Boer, V.M. (author), Morais, M.A. (author), Schipper, D. (author), Almering, M.J. (author), Kotter, P. (author), Dickinson, J.R. (author), Daran, J.M. (author), Pronk, J.T. (author)

journal article 2005

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Homofermentative Lactate Production Cannot Sustain Anaerobic Growth of Engineered Saccharomyces cerevisiae: Possible Consequence of Energy-Dependent Lactate Export

van Maris, A.J. (author), Winkler, A.A. (author), Porro, D. (author), van Dijken, J.P. (author), Pronk, J.T. (author)

journal article 2004

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Directed Evolution of Pyruvate Decarboxylase-Negative Saccharomyces cerevisiae, Yielding a C2-Independent, Glucose-Tolerant, and Pyruvate-Hyperproducing Yeast

van Maris, A.J. (author), Geertman, J.M. (author), Vermeulen, A. (author), Groothuizen, M.K. (author), Winkler, A.A. (author), Piper, M.D. (author), van Dijken, J.P. (author), Pronk, J.T. (author)

journal article 2004

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Prolonged Maltose-Limited Cultivation of Saccharomyces cerevisiae Selects for Cells with Improved Maltose Affinity and Hypersensitivity

Jansen, M.L.A. (author), Daran-Lapujade, P. (author), de Winde, J.H. (author), Piper, M.D. (author), Pronk, J.T. (author)

journal article 2004

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Overproduction of Threonine Aldolase Circumvents the Biosynthetic Role of Pyruvate Decarboxylase in Glucose-Limited Chemostat Cultures of Saccharomyces cerevisiae

van Maris, A.J. (author), Luttik, M.A. (author), Winkler, A.A. (author), van Dijken, J.P. (author), Pronk, J.T. (author)

journal article 2003

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Identification and Characterization of Phenylpyruvate Decarboxylase Genes in Saccharomyces cerevisiae

Vuralhan, Z. (author), Morais, M.A. (author), Tai, S.L. (author), Piper, M.D. (author), Pronk, J.T. (author)

journal article 2003

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Metabolic Engineering of Glycerol Production in Saccharomyces cerevisiae

Overkamp, K.M. (author), Bakker, B.M. (author), Kotter, P. (author), Luttik, M.A. (author), Van Dijken, J.P. (author), Pronk, J.T. (author)

journal article 2002

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Auxotrophic Yeast Strains in Fundamental and Applied Research

Pronk, J.T. (author)

journal article 2002

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Novel Pathway for Alcoholic Fermentation of delta-Gluconolactone in the Yeast Saccharomyces bulderi

van Dijken, J.P. (author), van Tuijl, A. (author), Luttik, M.A. (author), Middelhoven, W.J. (author), Pronk, J.T. (author)

journal article 2002

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Hxt-Carrier-Mediated Glucose Efflux upon Exposure of Saccharomyces cerevisiae to Excess Maltose

Jansen, M.L.A. (author), De Winde, J.H. (author), Pronk, J.T. (author)

journal article 2002

document

Van kleine diertgens naar cell factories

Pronk, J.T. (author)

public lecture 2000

document

The Mitochondrial Alcohol Dehydrogenase Adh3p Is Involved in a Redox Shuttle in Saccharomyces cerevisiae

Bakker, B.M. (author), Bro, C. (author), Kotter, P. (author), Luttik, M.A. (author), van Dijken, J.P. (author), Pronk, J.T. (author)

journal article 2000

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In Vivo Analysis of the Mechanisms for Oxidation of Cytosolic NADH by Saccharomyces cerevisiae Mitochondria

Overkamp, K.M. (author), Bakker, B.M. (author), Kotter, P. (author), van Tuijl, A. (author), de Vries, S. (author), van Dijken, J.P. (author), Pronk, J.T. (author)

journal article 2000

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The Saccharomyces cerevisiae ICL2 Gene Encodes a Mitochondrial 2-Methylisocitrate Lyase Involved in Propionyl-Coenzyme A Metabolism

Luttik, M.A. (author), Kotter, P. (author), Salomons, F.A. (author), van der Klei, I.J. (author), van Dijken, J.P. (author), Pronk, J.T. (author)

journal article 2000

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Effect of Specific Growth Rate on Fermentative Capacity of Baker¿s Yeast

Van Hoek, P. (author), Van Dijken, J.P. (author), Pronk, J.T. (author)

journal article 1998