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Limberger, Jon (author), Boxem, Thijs (author), Pluymaekers, Maarten (author), Bruhn, D.F. (author), Manzella, Adele (author), Calcagno, Philippe (author), Beekman, Fred (author), Cloetingh, S.A.P.L. (author), van Wees, Jan Diederik (author)In this paper we present results of a global resource assessment for geothermal energy within deep aquifers for direct heat utilization. Greenhouse heating, spatial heating, and spatial cooling are considered in this assessment. We derive subsurface temperatures from geophysical data and apply a volumetric heat-in-place method to improve...review 2018
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Wang, B. (author), Kreuger, R. (author), Beekman, F.J. (author), Goorden, M.C. (author)Anger cameras based on monolithic NaI scintillators read out by an array of PMTs are predominant in planar gamma imaging and SPECT. However, position estimation of gamma interactions is usually severely degraded near the edges of the scintillator which can be extremely undesirable for applications like breast imaging. Here we propose a...journal article 2018
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de Visser, H.M. (author), Korthagen, NM (author), Müller, C. (author), Ramakers, R.M. (author), Krijger, G.C. (author), Lafeber, F.P.J.G. (author), Beekman, F.J. (author), Mastbergen, S.C. (author), Weinans, Harrie (author)Objective. To evaluate the presence and localization of folate receptor expressing macrophages in the rat groove model of osteoarthritis and determine the suitability of a new folate conjugate with albumin-binding entity (cm09) for in vivo SPECT (single-photon emission computed tomography) analysis. Design. In male Wistar rats, local cartilage...journal article 2018
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Chen, Y. (author), Vastenhouw, B. (author), Wu, C. (author), Goorden, M.C. (author), Beekman, F.J. (author)SPECT can be used to image dopamine transporter (DaT) availability in the human striatum, e.g. for diagnosis of Parkinson's disease (PD). As traditional SPECT provides limited resolution and sensitivity, we proposed a full ring focusing multi-pinhole SPECT system (G-SPECT-I (Beekman 2015 Eur. J. Nucl. Med. Mol. Imaging 42 S209)) which...journal article 2018
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van Roosmalen, J. (author), Beekman, F.J. (author), Goorden, M.C. (author)Recently, we proposed and optimized dedicated multi-pinhole molecular breast tomosynthesis (MBT) that images a lightly compressed breast. As MBT may also be performed with other types of collimators, the aim of this paper is to optimize MBT with fan beam and slit-slat collimators and to compare its performance to that of multi-pinhole MBT to...journal article 2018
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Jennings, L. (author), Ivashchenko, O. (author), Marsman, I. J C (author), Laan, A.C. (author), Denkova, A.G. (author), Waton, G. (author), Beekman, F.J. (author), Schosseler, F. (author), Mendes, E. (author)Understanding how nanoparticle properties such as size, morphology and rigidity influence their circulation time and biodistribution is essential for the development of nanomedicine therapies. Herein we assess the influence of morphology on cellular internalization, in vivo biodistribution and circulation time of nanocarriers using...journal article 2016
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Goorden, M.C. (author), van Roosmalen, J. (author), van der Have, F. (author), Beekman, F.J. (author)The recently developed versatile emission computed tomography (VECTor) technology enables high-energy SPECT and simultaneous SPECT and PET of small animals at sub-mm resolutions. VECTor uses dedicated clustered pinhole collimators mounted in a scanner with three stationary large-area NaI(Tl) gamma detectors. Here, we develop and validate...journal article 2016
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Arranja, Alexandra (author), Ivashchenko, O. (author), Denkova, A.G. (author), Morawska, K.M. (author), Van Vlierberghe, Sandra (author), Dubruel, Peter (author), Waton, Gilles (author), Beekman, F.J. (author), Schosseler, François (author), Mendes, E. (author)Optimal biodistribution and prolonged circulation of nanocarriers improve diagnostic and therapeutic effects of enhanced permeability and retention-based nanomedicines. Despite extensive use of Pluronics in polymer-based pharmaceuticals, the influence of different poly(ethylene oxide) (PEO) block length and aggregation state on the...journal article 2016
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De Swart, Jan (author), Chan, Ho Sze (author), Goorden, M.C. (author), Morgenstern, Alfred (author), Bruchertseifer, Frank (author), Beekman, F.J. (author), de Jong, M. (author), Konijnenberg, Mark W. (author)The combined α-, γ-, and x-ray emitter <sup>213</sup>Bi (half-life, 46 min) is promising for radionuclide therapy. SPECT imaging of <sup>213</sup>Bi is challenging, because most emitted photons have a much higher energy (440 keV) than common in SPECT. We assessed <sup>213</sup>Bi imaging capabilities of the Versatile Emission Computed...journal article 2016
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- Passtoors, W.M. (author), Van den Akker, E.B. (author), Deelen, J. (author), Maier, A.B. (author), Van der Breggen, R. (author), Jansen, R. (author), Trompet, S. (author), Van Heemst, D. (author), Derhovanessian, E. (author), Pawelec, G. (author), Van Ommen, G.J.B. (author), Slagboom, P.E. (author), Beekman, M. (author) journal article 2015
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Boonstra, M.C. (author), Van Driel, P.B.A.A. (author), Van Willigen, D.M. (author), Stammes, M.A. (author), Prevoo, H.A.J.M. (author), Tummers, Q.R.J.G. (author), Mazar, A.P. (author), Beekman, F.J. (author), Kuppen, P.J.K. (author), Van de Velde, C.J.H. (author), Löwik, C.W.G.M. (author), Frangioni, J.V. (author), Van Leeuwen, F.W.B. (author), Sier, C.F.M. (author), Vahrmeijer, A.L. (author)Pre- and intraoperative diagnostic techniques facilitating tumor staging are of paramount importance in colorectal cancer surgery. The urokinase receptor (uPAR) plays an important role in the development of cancer, tumor invasion, angiogenesis, and metastasis and over-expression is found in the majority of carcinomas. This study aims to develop...journal article 2015
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Van Oosterom, M.N. (author), Kreuger, R. (author), Buckle, T. (author), Mahn, W.A. (author), Bunschoten, A. (author), Josephson, L. (author), Van Leeuwen, F.W.B. (author), Beekman, F.J. (author)Background: In vivo bioluminescence, fluorescence, and single-photon emission computed tomography (SPECT) imaging provide complementary information about biological processes. However, to date these signatures are evaluated separately on individual preclinical systems. In this paper, we introduce a fully integrated bioluminescence-fluorescence...journal article 2014
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Van den Akker, E.B. (author), Passtoors, W.M. (author), Jansen, R. (author), Van Zwet, E.W. (author), Goeman, J.J. (author), Hulsman, M. (author), Emilsson, V. (author), Perola, M. (author), Willemsen, G. (author), Penninx, B.W.J.H. (author), Heijmans, B.T. (author), Maier, A.B. (author), Boomsma, D.I. (author), Kok, J.N. (author), Slagboom, P.E. (author), Reinders, M.J.T. (author), Beekman, M. (author)The bodily decline that occurs with advancing age strongly impacts on the prospects for future health and life expectancy. Despite the profound role of age in disease etiology, knowledge about the molecular mechanisms driving the process of aging in humans is limited. Here, we used an integrative network-based approach for combining multiple...journal article 2013
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Beekman, F.J. (author), Bom, V.R. (author)A hadron radiation installation adapted to subject a target to irradiation by a hadron radiation beam, said installation comprising: - a target support configured to support, preferably immobilize, a target: - a hadron radiation apparatus adapted to emit a hadron radiation beam along a beam axis to irradiate the target supported by the target...patent 2013
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Wu, C. (author), Gratama van Andel, H.A. (author), Laverman, P. (author), Boerman, O.C. (author), Beekman, F.J. (author)Background In single-photon emission computed tomography (SPECT), attenuation of photon flux in tissue affects quantitative accuracy of reconstructed images. Attenuation maps derived from X-ray computed tomography (CT) can be employed for attenuation correction. The attenuation coefficients as well as registration accuracy between SPECT and CT...journal article 2013
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Bult, W. (author), Kroeze, S.G.C. (author), Elschot, M. (author), Seevinck, P.R. (author), Beekman, F.J. (author), De Jong, H.W.A.M. (author), Uges, D.R.A. (author), Kosterink, J.G.W. (author), Luijten, P.R. (author), Hennink, W.E. (author)The increasing incidence of small renal tumors in an aging population with comorbidities has stimulated the development of minimally invasive treatments. This study aimed to assess the efficacy and demonstrate feasibility of multimodality imaging of intratumoral administration of holmium-166 microspheres (166HoAcAcMS). This new technique locally...journal article 2013
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Branderhorst, W. (author), Vastenhouw, B. (author), Van der Have, F. (author), Blezer, E.L.A. (author), Bleeker, W.K. (author), Beekman, F.J. (author)Purpose: Small-animal single photon emission computed tomography (SPECT) with focused multi-pinhole collimation geometries allows scanning modes in which large amounts of photons can be collected from specific volumes of interest. Here we present new tools that improve targeted imaging of specific organs and tumours, and validate the effects of...journal article 2010
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Heemskerk, J.W.T. (author), Korevaar, M.A.N. (author), Huizenga, J. (author), Kreuger, R. (author), Schaart, D.R. (author), Goorden, M.C. (author), Beekman, F.J. (author)To improve multi-pinhole single photon emission computed tomography (SPECT) devices we are developing a high-resolution gamma detector consisting of a 3-mm-thick scintillation crystal that converts gamma photons to light, on top of an optically coupled high-resolution, high-sensitivity light sensor (EMCCD). This gamma camera can detect...journal article 2010
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Van Dam, H.T. (author), Seifert, S. (author), Vinke, R. (author), Dendooven, P. (author), Löhner, H. (author), Beekman, F.J. (author), Schaart, D.R. (author)The response of a silicon photomultiplier (SiPM) to optical signals is inherently nonproportional due to saturation, afterpulsing, and crosstalk. Existing models of the SiPM response do not account for all of these effects, and therefore, these models are not sufficiently accurate for many applications. In this work, a comprehensive model of the...journal article 2010
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Ji, C. (author), Van der Have, F. (author), Gratama van Andel, H. (author), Ramakers, R. (author), Beekman, F.J. (author)Spatially registering SPECT with CT makes it possible to anatomically localize SPECT tracers. In this study, an accurate method for the coregistration of ultra-high-resolution SPECT volumes andmultiple cone-beam CT volumes is developed and validated, which does not require markers during animal scanning. Methods. Transferable animal beds were...journal article 2010