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Wölfl, Benjamin (author), te Rietmole, Hedy (author), Salvioli, M. (author), Kaznatcheev, Artem (author), Thuijsman, Frank (author), Brown, Joel S. (author), Burgering, Boudewijn (author), Staňková, K. (author)Evolutionary game theory mathematically conceptualizes and analyzes biological interactions where one’s fitness not only depends on one’s own traits, but also on the traits of others. Typically, the individuals are not overtly rational and do not select, but rather inherit their traits. Cancer can be framed as such an evolutionary game, as it...review 2021
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Optimal control to reach eco-evolutionary stability in metastatic castrate-resistant prostate cancerCunningham, Jessica (author), Thuijsman, Frank (author), Peeters, Ralf (author), Viossat, Yannick (author), Brown, Joel (author), Gatenby, Robert (author), Staňková, K. (author)In the absence of curative therapies, treatment of metastatic castrate-resistant prostate cancer (mCRPC) using currently available drugs can be improved by integrating evolutionary principles that govern proliferation of resistant subpopulations into current treatment protocols. Here we develop what is coined as an ‘evolutionary stable...journal article 2020
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You, Li (author), von Knobloch, Maximilian (author), Lopez, Teresa (author), Peschen, Vanessa (author), Radcliffe, Sidney (author), Sam, Praveen Koshy (author), Thuijsman, Frank (author), Staňková, K. (author), Brown, Joel S. (author)For cancer, we develop a 2-D agent-based continuous-space game-theoretical model that considers cancer cells’ proximity to a blood vessel. Based on castrate resistant metastatic prostate cancer (mCRPC), the model considers the density and frequency (eco-evolutionary) dynamics of three cancer cell types: those that require exogenous...journal article 2019