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Paul, C.E. (author), Eggerichs, Daniel (author), Westphal, Adrie H. (author), Tischler, Dirk (author), van Berkel, Willem J.H. (author)Flavoprotein monooxygenases (FPMOs) are single- or two-component enzymes that catalyze a diverse set of chemo-, regio- and enantioselective oxyfunctionalization reactions. In this review, we describe how FPMOs have evolved from model enzymes in mechanistic flavoprotein research to biotechnologically relevant catalysts that can be applied for...review 2021
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Tischler, Dirk (author), Gädke, Eric (author), Eggerichs, Daniel (author), Gomez Baraibar, Alvaro (author), Mügge, Carolin (author), Scholtissek, Anika (author), Paul, C.E. (author)Ene-reductases allow regio- and stereoselective reduction of activated C=C double bonds at the expense of nicotinamide adenine dinucleotide cofactors [NAD(P)H]. Biological NAD(P)H can be replaced by synthetic mimics to facilitate enzyme screening and process optimization. The ene-reductase FOYE-1, originating from an acidophilic iron oxidizer...journal article 2020