The path towards prediction: An exploration of the evolutionary dynamics of the yeast polarity network

All living systems possess the ability to evolve. This ability has allowed life to adopt a large diversity of shapes, colors, sizes and lifestyles. However, despite being a fundamental property of life, our knowledge of what makes living systems evolvable is limited. The fact that evolution can be sometimes be hopelessly unpredictable while in...

On the chemo-mechanical evolution process of high-volume slag cement paste

This study investigated the evolution process of high-volume slag cement (HVSC) paste from a chemo-mechanical standpoint. HVSC specimens with a 70 w.t. % slag replacement rate were studied at various ages. Evolution of phase assemblage, microstructure development, and micromechanical properties were analyzed using TGA/XRD/MIP/SEM-EDS and nano...

The Enigma of Mind: A Theory of Evolution and Conscious Experience

Focusing on human capacity to design, the volume's final chapter draws attention to the fascinating role imagination can play in human life. The relationship between human consciousness and the evolution of the species continues to captivate and puzzle scholars. By revisiting the dialogue between consciousness and evolution, the authors...

Automated Evolutionary Engineering of Yeasts

Evolutionary engineering of microbes provides a powerful tool for untargeted optimization of (engineered) cell factories and identification of genetic targets for further research. Directed evolution is an intrinsically time-intensive effort, and automated methods can significantly reduce manual labor. Here, design considerations for various...

How Heritage Learns: Dutch Public Housing Heritage Evolution in Ecosystemic Perspective

How Heritage Learns explores the dynamics that come into play when public housing becomes valourised as heritage in the Netherlands and how that, in turn modulates the evolution of this protected housing. It builds on the foundation set by the thesis of Steward Brand, that buildings learn through the adaptation of their fabric to external forces...

The aging effect in evolving scientific citation networks

The study of citation networks is of interest to the scientific community. However, the underlying mechanism driving individual citation behavior remains imperfectly understood, despite the recent proliferation of quantitative research methods. Traditional network models normally use graph theory to consider articles as nodes and citations as...

Genomic analysis of Caldalkalibacillus thermarum TA2.A1 reveals aerobic alkaliphilic metabolism and evolutionary hallmarks linking alkaliphilic bacteria and plant life

The aerobic thermoalkaliphile Caldalkalibacillus thermarum strain TA2.A1 is a member of a separate order of alkaliphilic bacteria closely related to the Bacillales order. Efforts to relate the genomic information of this evolutionary ancient organism to environmental adaptation have been thwarted by the inability to construct a complete...

Genome analysis and engineering of industrial lager brewing yeasts

Lager beer, also referred to as Pilsner, is the most popular alcoholic beverage in the world, with an annual consumption of almost 200 billion litres per year. To make lager beer, brewer’s wort is fermented with the yeast <i style="mso-bidi-font-style:normal"...

Adaption to glucose limitation is modulated by the pleotropic regulator CcpA, independent of selection pressure strength

Background: A central theme in (micro)biology is understanding the molecular basis of fitness i.e. which strategies are successful under which conditions; how do organisms implement such strategies at the molecular level; and which constraints shape the trade-offs between alternative strategies. Highly standardized microbial laboratory...

Contractor cooperation mechanism and evolution of the green supply chain in mega projects

The large scale of construction in mega projects leads to significant environmental and socioeconomic impacts; thus, the projects should also exhibit greater social responsibility. Adopting green supply chain management in the construction process is an important way to realize the goal of sustainable development of mega projects. Because the...

Persistence and Lifelong Fidelity of Phase Singularities in Optical Random Waves

Phase singularities are locations where light is twisted like a corkscrew, with positive or negative topological charge depending on the twisting direction. Among the multitude of singularities arising in random wave fields, some can be found at the same location, but only when they exhibit opposite topological charge, which results in their...

Evolutionary dynamics in the fungal polarization network, a mechanistic perspective

Polarity establishment underlies proper cell cycle completion across virtually all organisms. Much progress has been made in generating an understanding of the structural and functional components of this process, especially in model species. Here we focus on the evolutionary dynamics of the fungal polarization protein network in order to...

Feature-Oriented Evolution of Variant-rich software systems

Most modern software systems can be adjusted to satisfy sets of conflicting requirements issued by different groups of users, based on their intended usage or execution context. For systems where configurations are a core concern, specific implementation mechanisms are put in place to allow the instantiation of sets of tailored components. Among...

Analysing the Linux kernel feature model changes using FMDiff

Evolving a large scale, highly variable system is a challenging task. For such a system, evolution operations often require to update consistently both their implementation and its feature model. In this context, the evolution of the feature model closely follows the evolution of the system. The purpose of this work is to show that fine...

A natural human hand model

We present a skeletal linked model of the human hand that has natural motion. We show how this can be achieved by introducing a new biology-based joint axis that simulates natural joint motion and a set of constraints that reduce an estimated 150 possible motions to twelve. The model is based on observation and literature. To facilitate testing...