Pages
- 1
- 2
- document
-
Huan, Z.G. (author), Leeflang, M.A. (author), Zhou, J. (author), Fratila-Apachitei, L.E. (author), Duszczyk, J. (author)Zinc and zirconium were selected as the alloying elements in biodegradable magnesium alloys, considering their strengthening effect and good biocompatibility. The degradation rate, hydrogen evolution, ion release, surface layer and in vitro cytotoxicity of two Mg–Zn–Zr alloys, i.e. ZK30 and ZK60, and a WE-type alloy (Mg–Y–RE–Zr) were...journal article 2010
- document
-
Wang, L. (author), Fang, G. (author), Qian, L. (author), Leeflang, M.A. (author), Duszczyk, J. (author), Zhou, J. (author)Magnesium alloys have, in recent years, been recognized as highly promising biodegradable materials, especially for vascular stent applications. Forming of magnesium alloys into high-precision thin-wall tubes has however presented a technological barrier in the fabrication of vascular stents, because of the poor workability of magnesium at room...journal article 2014
- document
-
Naddaf Dezfuli, S. (author), Huan, Z. (author), Mol, J.M.C. (author), Leeflang, M.A. (author), Chang, J. (author), Zhou, J. (author)The human body is a buffered environment where pH is effectively maintained. HEPES is a biological buffer often used to mimic the buffering activity of the body in in vitro studies on the degradation behavior of magnesium. However, the influence of HEPES on the degradation behavior of magnesium in the DMEM pseudo-physiological solution has not...journal article 2014
- document
-
Putra, N.E. (author), Leeflang, M.A. (author), Ducret, Verena (author), Patrulea, Viorica (author), Fratila-Apachitei, E.L. (author), Perron, Karl (author), Ye, Hua (author), Zhou, J. (author), Apachitei, I. (author), Zadpoor, A.A. (author)Implant-associated infections are highly challenging to treat, particularly with the emergence of multidrug-resistant microbials. Effective preventive action is desired to be at the implant site. Surface biofunctionalization of implants through Ag-doping has demonstrated potent antibacterial results. However, it may adversely affect bone...journal article 2022
- document
-
Li, Y. (author), Zhou, J. (author), Pavanram, P. (author), Leeflang, M.A. (author), Fockaert, L.I. (author), Pouran, B. (author), Tümer, N. (author), Schröder, K. U. (author), Mol, J.M.C. (author), Weinans, Harrie (author), Jahr, H. (author), Zadpoor, A.A. (author)An ideal bone substituting material should be bone-mimicking in terms of mechanical properties, present a precisely controlled and fully interconnected porous structure, and degrade in the human body to allow for full regeneration of large bony defects. However, simultaneously satisfying all these three requirements has so far been highly...journal article 2017
- document
-
Putra, N.E. (author), Leeflang, M.A. (author), Minneboo, M.B. (author), Taheri, P. (author), Fratila-Apachitei, E.L. (author), Mol, J.M.C. (author), Zhou, J. (author), Zadpoor, A.A. (author)Extrusion-based 3D printing followed by debinding and sintering is a powerful approach that allows for the fabrication of porous scaffolds from materials (or material combinations) that are otherwise very challenging to process using other additive manufacturing techniques. Iron is one of the materials that have been recently shown to be...journal article 2021
- document
-
Dong, J. (author), Tümer, N. (author), Leeflang, M.A. (author), Taheri, P. (author), Fratila-Apachitei, E.L. (author), Mol, J.M.C. (author), Zadpoor, A.A. (author), Zhou, J. (author)Porous biodegradable Mg and its alloys are considered to have a great potential to serve as ideal bone substitutes. The recent progress in additive manufacturing (AM) has prompted its application to fabricate Mg scaffolds with geometrically ordered porous structures. Extrusion-based AM, followed by debinding and sintering, has been recently...journal article 2022
- document
-
Putra, N.E. (author), Leeflang, M.A. (author), Taheri, P. (author), Fratila-Apachitei, E.L. (author), Mol, J.M.C. (author), Zhou, J. (author), Zadpoor, A.A. (author)Additively manufactured biodegradable porous iron has been only very recently demonstrated. Two major limitations of such a biomaterial are very low biodegradability and incompatibility with magnetic resonance imaging (MRI). Here, we present a novel biomaterial that resolves both of those limitations. We used extrusion-based 3D printing to...journal article 2021
- document
-
Dong, J. (author), Tümer, N. (author), Putra, N.E. (author), Zhu, Jia-Ning (author), Li, Y. (author), Leeflang, M.A. (author), Taheri, P. (author), Fratila-Apachitei, E.L. (author), Mol, J.M.C. (author), Zadpoor, A.A. (author), Zhou, J. (author)Additively manufactured (AM) biodegradable magnesium (Mg) scaffolds with precisely controlled and fully interconnected porous structures offer unprecedented potential as temporary bone substitutes and for bone regeneration in critical-sized bone defects. However, current attempts to apply AM techniques, mainly powder bed fusion AM, for the...journal article 2021
- document
-
Li, Y. (author), Jahr, H. (author), Lietaert, K. (author), Pavanram, P. (author), Yilmaz, A. (author), Fockaert, L.I. (author), Leeflang, M.A. (author), Pouran, B. (author), Gonzalez Garcia, Y. (author), Weinans, Harrie (author), Mol, J.M.C. (author), Zhou, J. (author), Zadpoor, A.A. (author)Additively manufactured (AM) topologically ordered porous metallic biomaterials with the proper biodegradation profile offer a unique combination of properties ideal for bone regeneration. These include a fully interconnected porous structure, bone-mimicking mechanical properties, and the possibility of fully regenerating bony defects. Most...journal article 2018
- document
-
Li, Y. (author), Lietaert, K. (author), Li, W. (author), Zhang, X.Y. (author), Leeflang, M.A. (author), Zhou, J. (author), Zadpoor, A.A. (author)The corrosion fatigue behavior of additively manufactured topologically ordered porous iron based on diamond unit cells was studied for the first time to understand its response to cyclic loading in a simulated physiological environment. The material exhibited high fatigue resistance with fatigue strengths being 70% and 65% of yield stress in...journal article 2019
- document
-
Bian, Dong (author), Zhou, Xiaochen (author), Liu, Jianing (author), Li, Wenting (author), Shen, Danni (author), Zheng, Yufeng (author), Gu, Wenda (author), Jiang, Jingjun (author), Li, Mei (author), Chu, Xiao (author), Ma, Limin (author), Wang, Xiaolan (author), Zhang, Yu (author), Leeflang, M.A. (author), Zhou, J. (author)Biodegradable stents can provide scaffolding and anti-restenosis benefits in the short term and then gradually disappear over time to free the vessel, among which the Mg-based biodegradable metal stents have been prosperously developed. In the present study, a Mg-8.5Li (wt.%) alloy (RE- and Al-free) with high ductility (> 40%) was...journal article 2021
- document
-
Putra, N.E. (author), Leeflang, M.A. (author), Klimopoulou, M. (author), Dong, J. (author), Taheri, P. (author), Huan, Z. (author), Fratila-Apachitei, E.L. (author), Mol, J.M.C. (author), Chang, J. (author), Zhou, J. (author), Zadpoor, A.A. (author)The development of biodegradable Fe-based bone implants has rapidly progressed in recent years. Most of the challenges encountered in developing such implants have been tackled individually or in combination using additive manufacturing technologies. Yet not all the challenges have been overcome. Herein, we present porous FeMn-akermanite...journal article 2023
- document
-
van Kootwijk, A. (author), Jonker, B. P. (author), Wolvius, E. B. (author), Cruz Saldivar, M. (author), Leeflang, M.A. (author), Zhou, J. (author), Tümer, N. (author), Mirzaali, Mohammad J. (author), Zadpoor, A.A. (author)Objective: Mandibular reconstruction using patient-specific cage implants is a promising alternative to the vascularized free flap reconstruction for nonirradiated patients with adequate soft tissues, or for patients whose clinical condition is not conducive to microsurgical reconstruction. This study aimed to assess the biomechanical...journal article 2023
- document
-
van Kootwijk, A. (author), Moosabeiki, Vahid (author), Cruz Saldivar, M. (author), Pahlavani, H. (author), Leeflang, M.A. (author), Kazemivand Niar, S. (author), Tümer, N. (author), Mirzaali, Mohammad J. (author), Zhou, J. (author), Zadpoor, A.A. (author)The reconstruction of large mandibular defects with optimal aesthetic and functional outcomes remains a major challenge for maxillofacial surgeons. The aim of this study was to design patient-specific mandibular reconstruction implants through a semi-automated digital workflow and to assess the effects of topology optimization on the...journal article 2022
- document
-
Putra, N.E. (author), Borg, K. G.N. (author), Diaz Payno, P.J. (author), Leeflang, M.A. (author), Klimopoulou, M. (author), Taheri, P. (author), Mol, J.M.C. (author), Fratila-Apachitei, E.L. (author), Zhou, J. (author), Zadpoor, A.A. (author)Advanced additive manufacturing techniques have been recently used to tackle the two fundamental challenges of biodegradable Fe-based bone-substituting materials, namely low rate of biodegradation and insufficient bioactivity. While additively manufactured porous iron has been somewhat successful in addressing the first challenge, the limited...journal article 2022
- document
-
Naddaf Dezfuli, S. (author), Huan, Z. (author), Mol, J.M.C. (author), Leeflang, M.A. (author), Chang, Jiang (author), Zhou, J. (author)The present research was aimed at developing magnesium-matrix composites that could allow effective control over their physiochemical and mechanical responses when in contact with physiological solutions. A biodegradable, bioactive ceramic - bredigite was chosen as the reinforcing phase in the composites, based on the hypothesis that the...journal article 2017
- document
-
Dong, J. (author), Lin, P. (author), Putra, N.E. (author), Tümer, N. (author), Leeflang, M.A. (author), Huan, Z. (author), Fratila-Apachitei, E.L. (author), Chang, J. (author), Zadpoor, A.A. (author), Zhou, J. (author)The treatment of femoral nonunion with large segmental bone defect is still challenging. Although magnesium alloys have been considered potential materials for such a treatment, their application is limited by their fast degradation. Adding bioceramic particles into magnesium to form Mg-matrix composites is a promising strategy to adjust...journal article 2022
- document
-
Liu, Yang (author), Wu, Yuanhao (author), Bian, Dong (author), Gao, Shuang (author), Leeflang, M.A. (author), Guo, Hui (author), Zheng, Yufeng (author), Zhou, J. (author)Novel Mg-(3.5, 6.5wt%)Li-(0.5, 2, 4wt%)Zn ternary alloys were developed as new kinds of biodegradable metallic materials with potential for stent application. Their mechanical properties, degradation behavior, cytocompatibility and hemocompatibility were studied. These potential biomaterials showed higher ultimate tensile strength than...journal article 2017
- document
-
Ye, Xiaotong (author), Leeflang, M.A. (author), Wu, Chengtie (author), Chang, Jiang (author), Zhou, J. (author), Huan, Z. (author)Porous Ti-6Al-4V scaffolds fabricated by means of selective laser melting (SLM),<br/>having controllable geometrical features and preferable mechanical properties, have been developed as a class of biomaterials that hold promising potential for bone repair. However, the inherent bio-inertness of the Ti-6Al-4V alloy as the matrix of the scaffolds...journal article 2017
Pages
- 1
- 2