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Muthusubramanian, N. (author), Finkel, M. (author), Duivestein, W.J. (author), Zachariadis, C. (author), van der Meer, S.L.M. (author), Veen, H.M. (author), Beekman, M.C. (author), Stavenga, T. (author), Bruno, A. (author), DiCarlo, L. (author)We investigate die-level and wafer-scale uniformity of Dolan-bridge and bridgeless Manhattan-style Josephson junctions, using multiple substrates with and without through-silicon vias (TSVs). Dolan junctions fabricated on planar substrates have the highest yield and lowest room-temperature conductance spread, equivalent to ∼ 100 M H z in...journal article 2024
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Sluiskes, Marije (author), Goeman, Jelle (author), Beekman, Marian (author), Slagboom, Eline (author), van den Akker, E.B. (author), Putter, H. (author), Rodríguez-Girondo, Mar (author)Aging is a multifaceted and intricate physiological process characterized by a gradual decline in functional capacity, leading to increased susceptibility to diseases and mortality. While chronological age serves as a strong risk factor for age-related health conditions, considerable heterogeneity exists in the aging trajectories of...journal article 2024
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Cosmi, V. (author), Wang, B. (author), Goorden, M.C. (author), Beekman, F.J. (author)Background: Gamma camera imaging, including single photon emission computed tomography (SPECT), is crucial for research, diagnostics, and radionuclide therapy. Gamma cameras are predominantly based on arrays of photon multipliers tubes (PMTs) that read out NaI(Tl) scintillation crystals. In this way, standard gamma cameras can localize ɣ-rays...journal article 2024
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Nguyen, M.P. (author), Arif, M. (author), Oostenrijk, Bart (author), Goorden, M.C. (author), Beekman, F.J. (author)Microscopic nuclear imaging down to spatial resolutions of a few hundred microns can already be achieved using low-energy gamma emitters (e.g. <sup>125</sup>I, ∼30 keV) and a basic single micro-pinhole gamma camera. This has been applied to in vivo mouse thyroid imaging, for example. For clinically used radionuclides such as <sup>99m</sup>Tc,...journal article 2023
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Tišma, M. (author), Janissen, R. (author), Antar, Hammam (author), Martin Gonzalez, A. (author), Barth, R. (author), Beekman, T.G.T. (author), van der Torre, J. (author), Michieletto, Davide (author), Gruber, Stephan (author), Dekker, C. (author)In most bacteria, chromosome segregation is driven by the ParABS system where the CTPase protein ParB loads at the parS site to trigger the formation of a large partition complex. Here, we present in vitro studies of the partition complex for Bacillus subtilis ParB, using single-molecule fluorescence microscopy and AFM imaging to show that...journal article 2023
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Bizzarri, D. (author), Reinders, M.J.T. (author), Beekman, Marian (author), Slagboom, P. Eline (author), van den Akker, E.B. (author)1H-NMR metabolomics data is increasingly used to track health and disease. Nightingale Health, a major supplier of 1H-NMR metabolomics, has recently updated the quantification strategy to further align with clinical standards. Such updates, however, might influence backward replicability, particularly affecting studies with repeated measures....journal article 2023
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van der Burgt, Margot C.A. (author), Mérelle, Saskia (author), Brinkman, W.P. (author), Beekman, Aartjan T.F. (author), Gilissen, Renske (author)Background: Globally, suicide is among the leading causes of death, with men being more at risk to die from suicide than women. Research suggests that people with suicidal ideation often struggle to find adequate help. Every month, around 4000 people fill in the anonymous self-test for suicidal thoughts on the website of the Dutch suicide...journal article 2023
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Handula, M. (author), Beekman, Savanne (author), Konijnenberg, Mark (author), Stuurman, Debra (author), de Ridder, Corrina (author), Bruchertseifer, Frank (author), Morgenstern, Alfred (author), Denkova, A.G. (author), de Blois, Erik (author), Seimbille, Y. (author)Background: The [<sup>177</sup>Lu]Lu-DOTA-TATE mediated peptide receptor radionuclide therapy (PRRT) of neuroendocrine tumors (NETs) is sometimes leading to treatment resistance and disease recurrence. An interesting alternative could be the somatostatin antagonist, [<sup>177</sup>Lu]Lu-DOTA-JR11, that demonstrated better biodistribution...journal article 2023
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Varbanov, B.M. (author), Finkel, M. (author), Veen, H.M. (author), van der Meer, S.L.M. (author), Valles Sanclemente, S. (author), Muthusubramanian, N. (author), Beekman, M.C. (author), Haider, S.N. (author), Terhal, B.M. (author), DiCarlo, L. (author)Minimizing leakage from computational states is a challenge when using many-level systems like superconducting quantum circuits as qubits. We realize and extend the quantum-hardware-efficient, all-microwave leakage reduction unit (LRU) for transmons in a circuit QED architecture proposed by Battistel et al. This LRU effectively reduces...journal article 2023
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Valles Sanclemente, S. (author), van der Meer, S.L.M. (author), Finkel, M. (author), Muthusubramanian, N. (author), Beekman, M.C. (author), Ali, H.A.S. (author), Ferreira Marques, J.M. (author), Zachariadis, C. (author), Veen, H.M. (author), Stavenga, T. (author), Haider, S.N. (author), DiCarlo, L. (author)We present the use of a set of airbridges to trim the frequency of microwave coplanar-waveguide (CPW) resonators post-fabrication. This method is compatible with the fabrication steps of conventional CPW airbridges and crossovers and increases device yield by allowing compensation of design and fabrication uncertainty with 100 MHz range and...journal article 2023
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Vlothuizen, W.J. (author), Ferreira Marques, J.M. (author), van Straten, J. (author), Ali, H. (author), Muthusubramanian, N. (author), Zachariadis, C. (author), van Someren, J. (author), Beekman, M. (author), Haider, S.N. (author), Bruno, A. (author), Almudever, Carmen G. (author), DiCarlo, L. (author)Artificial neural networks are becoming an integral part of digital solutions to complex problems. However, employing neural networks on quantum processors faces challenges related to the implementation of non-linear functions using quantum circuits. In this paper, we use repeat-until-success circuits enabled by real-time control-flow...journal article 2023
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Lilius, Tuomas O. (author), Mortensen, Kristian Nygaard (author), Deville, Claire (author), Lohela, Terhi J. (author), Stæger, Frederik Filip (author), Sigurdsson, Björn (author), Rosenholm, Marko (author), Beekman, F.J. (author), Jensen, Andreas I. (author)Nanoparticles are ultrafine particulate matter having considerable potential for treatment of central nervous system (CNS) disorders. Despite their tiny size, the blood-brain barrier (BBB) restricts their access to the CNS. Their direct cerebrospinal fluid (CSF) administration bypasses the BBB endothelium, but still fails to give adequate...journal article 2023
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van Dijk, Bruce (author), Hooning van Duyvenbode, J. Fred F. (author), de Vor, Lisanne (author), Nurmohamed, F. Ruben H.A. (author), Lam, Marnix G.E.H. (author), Poot, Alex J. (author), Ramakers, R.M. (author), Koustoulidou, Sofia (author), Beekman, F.J. (author), Weinans, Harrie (author)Implant infections caused by Staphylococcus aureus are difficult to treat due to biofilm formation, which complicates surgical and antibiotic treatment. We introduce an alternative approach using monoclonal antibodies (mAbs) targeting S. aureus and provide evidence of the specificity and biodistribution of S.-aureus-targeting antibodies in a...journal article 2023
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de Vor, Lisanne (author), van Dijk, Bruce (author), van Kessel, Kok (author), Kavanaugh, Jeffrey S. (author), de Haas, Carla (author), Aerts, Piet C. (author), Ramakers, R.M. (author), Beekman, F.J. (author), Weinans, Harrie (author)Implant-associated Staphylococcus aureus infections are difficult to treat because of biofilm formation. Bacteria in a biofilm are often insensitive to antibiotics and host immunity. Monoclonal antibodies (mAbs) could provide an alternative approach to improve the diagnosis and potential treatment of biofilm-related infections. Here, we show...journal article 2022
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Bizzarri, D. (author), Reinders, M.J.T. (author), Beekman, M. (author), Slagboom, P. E. (author), van den Akker, E.B. (author)Background: Missing or incomplete phenotypic information can severely deteriorate the statistical power in epidemiological studies. High-throughput quantification of small-molecules in bio-samples, i.e. ‘metabolomics’, is steadily gaining popularity, as it is highly informative for various phenotypical characteristics. Here we aim to leverage...journal article 2022
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Liu, H. (author), de Kruijff, R.M. (author), Laan, A.C. (author), Beekman, F.J. (author), van den Heuvel, E.J. (author), Ramakers, R.M. (author), Eelkema, R. (author), Denkova, A.G. (author)A variety of polymer micelles are designed for the delivery of chemotherapeutic drugs to tumors. Although the promise of these nanocarriers is very high, in the clinic the effectivity is rather limited. Determining the in vivo fate of the micelles can greatly help to improve this treatment. Here, a simple and fast chelator-free method for...journal article 2022
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Bizzarri, D. (author), Reinders, M.J.T. (author), Beekman, M. (author), Slagboom, P. E. (author), van den Akker, E.B. (author)Motivation: 1H-NMR metabolomics is rapidly becoming a standard resource in large epidemiological studies to acquire metabolic profiles in large numbers of samples in a relatively low-priced and standardized manner. Concomitantly, metabolomics-based models are increasingly developed that capture disease risk or clinical risk factors. These...journal article 2022
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Bogaards, Fatih A. (author), Gehrmann, Thies (author), Beekman, Marian (author), van den Akker, E.B. (author), van de Rest, Ondine (author), Hangelbroek, Roland W.J. (author), Noordam, Raymond (author), Mooijaart, Simon P. (author), Reinders, M.J.T. (author)The response to lifestyle intervention studies is often heterogeneous, especially in older adults. Subtle responses that may represent a health gain for individuals are not always detected by classical health variables, stressing the need for novel biomarkers that detect intermediate changes in metabolic, inflammatory, and immunity-related...journal article 2022
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Nguyen, M.P. (author), Goorden, M.C. (author), Ramakers, R.M. (author), Beekman, F.J. (author)The use of multi-pinhole collimation has enabled ultra-high-resolution imaging of SPECT and PET tracers in small animals. Key for obtaining high-quality images is the use of statistical iterative image reconstruction with accurate energy-dependent photon transport modelling through collimator and detector. This can be incorporated in a system...journal article 2021
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Chen, Y. (author), Goorden, M.C. (author), Beekman, F.J. (author)SPECT imaging with 123I-FP-CIT is used for diagnosis of neurodegenerative disorders like Parkinson's disease. Attenuation correction (AC) can be useful for quantitative analysis of 123I-FP-CIT SPECT. Ideally, AC would be performed based on attenuation maps (μ-maps) derived from perfectly registered CT scans. Such μ-maps, however, are most...journal article 2021