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Geelen, J.E. (author), van der Helm, F.C.T. (author), Schouten, A.C. (author), Mugge, W. (author)Human hands are complex biomechanical systems that allow for dexterous tasks with many degrees of freedom. Coordination of the fingers is essential for many activities of daily living and involves integrating sensory signals. During this sensory integration, the central nervous system deals with the uncertainty of sensory signals. When...journal article 2023
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van den Berg, Boudewijn (author), Manoochehri, M. (author), Schouten, A.C. (author), van der Helm, F.C.T. (author), Buitenweg, Jan R. (author)Recent studies have established the presence of nociceptive steady-state evoked potentials (SSEPs), generated in response to thermal or intra-epidermal electric stimuli. This study explores cortical sources and generation mechanisms of nociceptive SSEPs in response to intra-epidermal electric stimuli. Our method was to stimulate healthy...journal article 2022
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van der Cruijsen, J. (author), Dooren, R.F. (author), Schouten, A.C. (author), Oostendorp, Thom F. (author), Frens, Maarten A. (author), Ribbers, G.M. (author), van der Helm, F.C.T. (author), Kwakkel, Gert (author), Selles, R.W. (author)Transcranial direct current stimulation (tDCS) is a promising tool to improve and speed up motor rehabilitation after stroke, but inconsistent clinical effects refrain tDCS from clinical implementation. Therefore, this study aimed to assess the need for individualized tDCS configurations in stroke, considering interindividual variability in...journal article 2022
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van Kordelaar, J. (author), van de Ruit, M.L. (author), Solis Escalante, T. (author), Aerden, Leo A.M. (author), Meskers, Carel G.M. (author), van Wegen, Erwin E.H. (author), Schouten, A.C. (author), Kwakkel, Gert (author), van der Helm, F.C.T. (author)Background: Proprioception is important for regaining motor function in the paretic upper extremity after stroke. However, clinical assessments of proprioception are subjective and require verbal responses from the patient to applied proprioceptive stimuli. Cortical responses evoked by robotic wrist perturbations and measured by...journal article 2021
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van den Berg, Boudewijn (author), Manoochehri, M. (author), Kasting, Mindy (author), Schouten, A.C. (author), van der Helm, F.C.T. (author), Buitenweg, Jan R. (author)A sustained sensory stimulus with a periodic variation of intensity creates an electrophysiological brain response at associated frequencies, referred to as the steady-state evoked potential (SSEP). The SSEPs elicited by the periodic stimulation of nociceptors in the skin may represent activity of a brain network that is primarily involved in...journal article 2021
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Geelen, J.E. (author), Branco, Mariana P. (author), Ramsey, Nick F. (author), van der Helm, F.C.T. (author), Mugge, W. (author), Schouten, A.C. (author)Motion capture systems are extensively used to track human movement to study healthy and pathological movements, allowing for objective diagnosis and effective therapy of conditions that affect our motor system. Current motion capture systems typically require marker placements which is cumbersome and can lead to contrived movements.Here, we...conference paper 2021
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Yang, Y. (author), Yao, Jun (author), Dewald, Julius (author), van der Helm, F.C.T. (author), Schouten, A.C. (author)This paper introduces the Cross-frequency Amplitude Transfer Function (CATF), a model-free method for quantifying nonlinear stimulus-response interaction based on phase-locked amplitude relationship. The CATF estimates the amplitude transfer from input frequencies at stimulation signal to their harmonics/intermodulation at the response signal....journal article 2020
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Vlaar, M.P. (author), Birpoutsoukis, Georgios (author), Lataire, John (author), Schouten, A.C. (author), Schoukens, Johan (author), van der Helm, F.C.T. (author)Joint manipulation elicits a response from the sensors in the periphery which, via the spinal cord, arrives in the cortex. The average evoked cortical response recorded using electroencephalography was shown to be highly nonlinear; a linear model can only explain 10% of the variance of the evoked response, and over 80% of the response is...journal article 2018
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Filatova, O.G. (author), van Vliet, L.J. (author), Schouten, A.C. (author), Kwakkel, Gert (author), van der Helm, F.C.T. (author), Vos, F.M. (author)Better insight into white matter (WM) alterations after stroke onset could help to understand the underlying recovery mechanisms and improve future interventions. MR diffusion imaging enables to assess such changes. Our goal was to investigate the relation of WM diffusion characteristics derived from diffusion models of increasing complexity...journal article 2018
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Gursel Ozmen, Nurhan (author), van der Helm, F.C.T. (author), Schouten, A.C. (author)The modeling of the dynamic behavior of the human arm is an important issue in robotics, biomedical and medical fields. In this study, it was aimed to construct an inverse dynamics model for the sequential motion of the arm subjected to external force fluctuations using a two degree of freedom manipulator. In experiments with healthy...conference paper 2018
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van de Ruit, M.L. (author), Cavallo, Gaia (author), Lataire, John (author), van der Helm, F.C.T. (author), Mugge, W. (author), van Wingerden, J.W. (author), Schouten, A.C. (author)During movements, humans continuously regulate their joint impedance to minimize control effort and optimize performance. Joint impedance describes the relationship between a joint's position and torque acting around the joint. Joint impedance varies with joint angle and muscle activation and differs from trial-to-trial due to inherent...journal article 2018
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Kalogianni, K. (author), Daffertshofer, Andreas (author), van der Helm, F.C.T. (author), Schouten, A.C. (author), de Munck, Jan C. (author)In searching for clinical biomarkers of the somatosensory function, we studied reproducibility of somatosensory potentials (SEP) evoked by finger stimulation in healthy subjects. SEPs induced by electrical stimulation and especially after median nerve stimulation is a method widely used in the literature. It is unclear, however, if the EEG...journal article 2018
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van de Ruit, M.L. (author), Lataire, John (author), van der Helm, F.C.T. (author), Mugge, W. (author), Schouten, A.C. (author)During movement, our central nervous system (CNS) takes into account the dynamics of our environment to optimally adapt our joint dynamics. In this study we explored the adaptation of shoulder joint dynamics when a participant interacted with a time-varying virtual environment created by a haptic manipulator. Participants performed a position...conference paper 2018
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Mugge, W. (author), van Hilten, Jacobus J. (author), van der Helm, F.C.T. (author), Schouten, A.C. (author)This paper focuses on the pathophysiology of fixed dystonia (i.e., sustained muscle contractions resulting in abnormal postures) in Complex Regional Pain Syndrome from an engineering point of view. Although the mechanisms are still elusive, the evidence implicating involvement of aberrant muscle force feedback is compelling. A neuromuscular...conference paper 2018
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Forbes, P.A. (author), de Bruijn, E. (author), Nijmeijer, SWR (author), Koelman, JHTM (author), van der Helm, F.C.T. (author), Schouten, A.C. (author), Tijssen, MAJ (author), Happee, R. (author)Background Effective sensorimotor integration is essential to modulate (adapt) neck stabilization strategies in response to varying tasks and disturbances. This study evaluates the hypothesis that relative to healthy controls cervical dystonia patients have an impaired ability to modulate afferent feedback for neck stabilization with changes...journal article 2017
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Wu, Y. (author), Nieuwenhoff, M.D. (author), Huygen, F.J.P.M. (author), van der Helm, F.C.T. (author), Niehof, S.P. (author), Schouten, A.C. (author)Small nerve fibers regulate local skin blood flow in response to local thermal perturbations. Small nerve fiber function is difficult to assess with classical neurophysiological tests. In this study, a vasomotor response model in combination with a heating protocol was developed to quantitatively characterize the control mechanism of small...journal article 2017
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Vlaar, M.P. (author), Solis Escalante, T. (author), Vardy, A.N. (author), van der Helm, F.C.T. (author), Schouten, A.C. (author)Cortical responses to continuous stimuli as recorded using either magneto- or electroencephalography (EEG) have shown power at harmonics of the stimulated<br/>frequency, indicating nonlinear behavior. Even though the selection of analysis techniques depends on the linearity of the system under study, the importance of nonlinear contributions to...journal article 2017
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Vlaar, M.P. (author), Solis Escalante, T. (author), Dewald, J.P.A. (author), Van Wegen, Erwin E H (author), Schouten, A.C. (author), Kwakkel, G. (author), van der Helm, F.C.T. (author)Background: Cortical damage after stroke can drastically impair sensory and motor function of the upper limb, affecting the execution of activities of daily living and quality of life. Motor impairment after stroke has been thoroughly studied, however sensory impairment and its relation to movement control has received less attention. Integrity...journal article 2017
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Yang, Y. (author), Dewald, J.P.A. (author), van der Helm, F.C.T. (author), Schouten, A.C. (author)Neural coupling between the central nervous system and the periphery is essential for the neural control of movement. Corticomuscular coherence is a popular linear technique to assess synchronised oscillatory activity in the sensorimotor system. This oscillatory coupling originates from ascending somatosensory feedback and descending motor...journal article 2017
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Nieuwenhoff, MD (author), Wu, Y. (author), Huygen, F.J.P.M. (author), Schouten, A.C. (author), van der Helm, F.C.T. (author), Niehof, SP (author)Introduction: Small nerve fiber dysfunction is an early feature of diabetic neuropathy. There is a strong clinical need for a non-invasive method to assess small nerve fiber function. Small nerve fibers mediate axon reflex-related vasodilation and play an important role in thermoregulation. Assessing the reflex vasodilation after local heating...journal article 2016
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