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Kuperus, J.S. (author), Smit, E.J.M. (author), Pouran, B. (author), van Hamersvelt, R.W. (author), van Stralen, Marijn (author), Seevinck, P.R. (author), Buckens, C.F. (author), Bleys, Ronald L.A.W. (author), Weinans, Harrie (author), Oner, F. C. (author), de Jong, P.A. (author), Verlaan, J-J (author)Diffuse idiopathic skeletal hyperostosis (DISH) is often theorized to be an ossification of the anterior longitudinal ligament (ALL). Using computed tomography (CT) imaging and cryomacrotome sectioning, we investigated the spatial relationship between the ALL and newly formed bone in DISH to test this hypothesis. In the current study, four...journal article 2018
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Komor, Malgorzata A. (author), Bosch, Linda J.W. (author), Bounova, Gergana (author), Bolijn, Anne S. (author), Delis‐van Diemen, Pien M. (author), Rausch, Christian (author), Hoogstrate, Youri (author), Stubbs, Andrew P. (author), de Jong, Mark (author), Wessels, L.F.A. (author)Consensus molecular subtyping is an RNA expression-based classification system for colorectal cancer (CRC). Genomic alterations accumulate during CRC pathogenesis, including the premalignant adenoma stage, leading to changes in RNA expression. Only a minority of adenomas progress to malignancies, a transition that is associated with specific...journal article 2018
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Chen, C. (author), Chen, Z. (author), Bera, Deep (author), Noothout, E.C. (author), Chang, Z.Y. (author), Tan, M. (author), Vos, H.J. (author), Bosch, Johan G. (author), Verweij, M.D. (author), de Jong, N. (author), Pertijs, M.A.P. (author)This paper presents a front-end application-specified integrated circuit (ASIC) integrated with a 2-D PZT matrix transducer that enables in-probe digitization with acceptable power dissipation for the next-generation endoscopic and catheter-based 3-D ultrasound imaging systems. To achieve power-efficient massively parallel analog-to-digital...journal article 2018
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Mattoni, G. (author), de Jong, B.W.A. (author), Manca, N. (author), Tomellini, M. (author), Caviglia, A. (author)Hydrogen-related technologies are rapidly developing, driven by the necessity of efficient and high-density energy storage. This poses new challenges to the detection of dangerous gases, in particular the realization of cheap, sensitive, and fast hydrogen sensors. Several materials are being studied for this application, but most present...journal article 2018
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de Bok, M.A. (author), de Jong, Gerard (author), Tavasszy, Lorant (author), Van Meijeren, Jaco (author), Davydenko, Igor (author), Benjamins, Michiel (author), Groot, Noortje (author), Miete, Onno (author), Van den Berg, Monique (author)A large part of freight transport movements are part of a multimodal transport chain, in particular for port-related containerized transport flows. Because data of multimodal transports are unavailable it is challenging to develop a multimodal transport chain models. This paper describes the development of a new module for multimodal transport...journal article 2018
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Skachkov, Ilya (author), Luan, Ying (author), Van Tiel, Sandra T. (author), van der Steen, A.F.W. (author), de Jong, N. (author), Bernsen, Monique R. (author), Kooiman, Klazina (author)In vivo cell tracking of therapeutic, tumor, and endothelial cells is an emerging field and a promising technique for imaging cardiovascular disease and cancer development. Site-specific labeling of endothelial cells with the MRI contrast agent superparamagnetic iron oxide (SPIO) in the absence of toxic agents is challenging. Therefore, the...journal article 2018
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Cioni, Bianca (author), Nevedomskaya, Ekaterina (author), Melis, Monique H.M. (author), van Burgsteden, Johan (author), Stelloo, Suzan (author), Hodel, Emma (author), Spinozzi, Daniele (author), de Jong, Jeroen (author), Wessels, L.F.A. (author)Fibroblasts are abundantly present in the prostate tumor microenvironment (TME), including cancer-associated fibroblasts (CAFs) which play a key role in cancer development. Androgen receptor (AR) signaling is the main driver of prostate cancer (PCa) progression, and stromal cells in the TME also express AR. High-grade tumor and poor clinical...journal article 2018
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Mu, R. (author), de Jong, W.M. (author)To promote sustainable urbanization and combat the economic, environmental, energy and safety issues that go with rapid motorization, the Ministry of Transport in China has introduced the “Transit Metropolis” program with a substantive amount of funds devoted to the implementation of the program in local governments. This represents the largest...journal article 2018
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Xiong, Lichun (author), de Jong, W.M. (author), Wang, Fengting (author), Cheng, Baodong (author), Yu, Chang (author)Promoting the rise of Central China is one of the most important national strategies regarding the promotion of China's economic development. However, the environmental issues in the central regions have become remarkably severe. It is therefore worthwhile exploring how economic development and environmental protection can be coordinated....journal article 2018
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Transport Demand Management Policy Integration in Chinese Cities: A Proposed Analysis of Its EffectsYang, W. (author), Veeneman, Wijnand (author), de Jong, W.M. (author)Transport demand management (TDM) measures are widely regarded as essential tools to deal with traffic issues. Their effectiveness has been under scrutiny. Packaging of TDM measures has recently received much attention from researchers and governments because it can achieve more complex policy goals and resolve the negative effects of single TDM...journal article 2018
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Çelik, M. (author), Paulussen, Geert (author), van Erp, Dennis (author), de Jong, W. (author), Boersma, B.J. (author)Rotating wickless and stationary capillary cylindrical heat pipes are widely used heat transfer devices. Transient behavior of such heat pipes has been investigated numerically with computational fluid dynamics and lumped parameter models. In this paper, the advantages of both methods are combined into a novel engineering model that is low in...journal article 2018
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Çelik, M. (author), Devendran, Kathikeyan (author), Paulussen, Geert (author), Pronk, Pepijn (author), Frinking, Ferry (author), de Jong, W. (author), Boersma, B.J. (author)A new concept for energy efficient annealing of steel strip comprises of multiple rotating heat pipes. Each heat pipe extracts heat from the cooling strip which is reused to increase the temperature of the heating strip. In this context, the heat transfer between the steel strip and the rotating heat pipe is investigated. When the strip is...journal article 2018
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Khalilnezhad, H. (author), Popov, M. (author), van der Sluis, L. (author), Bos, Jorrit A. (author), de Jong, Jan P.W. (author), Ametani, Akihiro (author)Zero-missing is a phenomenon in shunt compensated cable systems in which the current through the line breaker does not cross the zero point for several cycles. This paper deals with a thorough investigation on countermeasures of the zero-missing phenomenon in transmission systems and determines the requirements, benefits, and risks of...journal article 2018
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de Jong, R. (author), de Puit, M. (author)Lanthanide-based (Eu and Tb) metal organic frameworks (MOFs) synthesized in this work are highly fluorescent crystalline structures that form through a self-assembly process in an aqueous environment. Various bio-organic molecules, including proteins and amino acids, can act as inducing agents for this process. The fact that these components...journal article 2018
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Kruizinga, P. (author), van der Meulen, P.F. (author), Fedjajevs, A. (author), Mastik, F (author), Springeling, Geert (author), de Jong, N. (author), Bosch, J.G. (author), Leus, G.J.T. (author)Three-dimensional ultrasound is a powerful imaging technique, but it requires thousands of sensors and complex hardware. Very recently, the discovery of compressive sensing has shown that the signal structure can be exploited to reduce the burden posed by traditional sensing requirements. In this spirit, we have designed a simple ultrasound...journal article 2017
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Sun, X. (author), Olivos Suarez, A.I. (author), Meijerink, Mark (author), Van Deelen, Tom (author), Ould-Chikh, Samy (author), Zečević, Jovana (author), de Jong, K.M. (author), Kapteijn, F. (author), Gascon, Jorge (author)The development of synthetic protocols for the preparation of highly loaded metal nanoparticle-supported catalysts has received a great deal of attention over the last few decades. Independently controlling metal loading, nanoparticle size, distribution, and accessibility has proven challenging because of the clear interdependence between...journal article 2017
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Strachinaru, Mihai (author), Bosch, Johan G. (author), van Dalen, Bas M. (author), van Gils, Lennart (author), van der Steen, A.F.W. (author), de Jong, N. (author), Geleijnse, Marcel L. (author), Vos, H.J. (author)The propagation velocity of shear waves relates to tissue stiffness. We prove that a regular clinical cardiac ultrasound system can determine shear wave velocity with a conventional unmodified tissue Doppler imaging (TDI) application. The investigation was performed on five tissue phantoms with different stiffness using a research platform...journal article 2017
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Kokhuis, Tom J A (author), Naaijkens, Benno A. (author), Juffermans, Lynda J.M. (author), Kamp, Otto (author), van der Steen, A.F.W. (author), Versluis, Michel (author), de Jong, N. (author)The use of stem cells for regenerative tissue repair is promising but hampered by the low number of cells delivered to the site of injury. To increase the delivery, we propose a technique in which stem cells are linked to functionalized microbubbles, creating echogenic complex dubbed StemBells. StemBells are highly susceptible to acoustic...journal article 2017
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van Rooij, Tom (author), Beekers, D.I. (author), Lattwein, Kirby R. (author), van der Steen, A.F.W. (author), de Jong, N. (author), Kooiman, Klazina (author)One of the main challenges for ultrasound molecular imaging is acoustically distinguishing nonbound microbubbles from those bound to their molecular target. In this in vitro study, we compared two types of in-house produced targeted lipid-coated microbubbles, either consisting of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine, C16:0 (DPPC) or 1...journal article 2017
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Cohen, M.A. (author), Yuan, M. (author), de Jong, B.W.A. (author), Beukers, Ewout (author), Bosman, S.J. (author), Steele, G.A. (author)We report on a technique for applying a DC bias in a 3D microwave cavity. We achieve this by isolating the two halves of the cavity with a dielectric and directly using them as DC electrodes. As a proof of concept, we embed a variable capacitance diode in the cavity and tune the resonant frequency with a DC voltage, demonstrating the...journal article 2017