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Naghavi Zadeh, S.M. (author), Alijani, F. (author), Chen, X. (author), Dayyani, Iman (author), Yasaee, Mehdi (author), Mirzaali, Mohammad J. (author), Zadpoor, A.A. (author)Mechanical metamaterials are advanced engineering materials that exhibit unusual properties that cannot be found in nature. The elastic properties (i.e., elastic modulus and Poisson's ratio) of mechanical metamaterials can be tuned by changing the geometry of their fundamental unit cells. This allows for the design of metamaterial lattices...journal article 2021
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Gijsen, F.J.H. (author), Vis, Bas (author), Barrett, Hilary E. (author), Zadpoor, A.A. (author), Verhagen, Hence J. (author), Bos, Daniel (author), van der Steen, A.F.W. (author), Akyildiz, A.C. (author)Objective: Atherosclerotic plaque rupture in carotid arteries is a major source of cerebrovascular events. Calcifications are highly prevalent in carotid plaques, but their role in plaque rupture remains poorly understood. This work studied the morphometric features of calcifications in carotid plaques and their effect on the stress...journal article 2021
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Janbaz, S. (author), Hedayati, R. (author), Zadpoor, A.A. (author)Nature uses various activation mechanisms to program complex transformations in the shape and functionality of living organisms. Inspired by such natural events, we aimed to develop initially flat (i.e. two-dimensional) programmable materials that, when triggered by a stimulus such as temperature, could self-transform their shape into a complex...journal article 2016
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Bobbert, F.S.L. (author), Lietaert, K. (author), Eftekhari, A.A. (author), Pouran, B. (author), Ahmadi, S.M. (author), Weinans, Harrie (author), Zadpoor, A.A. (author)Porous biomaterials that simultaneously mimic the topological, mechanical, and mass transport properties of bone are in great demand but are rarely found in the literature. In this study, we rationally designed and additively manufactured (AM) porous metallic biomaterials based on four different types of triply periodic minimal surfaces (TPMS)...journal article 2017
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Bobbert, F.S.L. (author), Zadpoor, A.A. (author)The success of bone substitutes used to repair bone defects such as critical sized defects depends on the architecture of the porous biomaterial. The architectural parameters and surface properties affect cell seeding efficiency, cell response, angiogenesis, and eventually bone formation. The relevant parameters include pore size and porosity,...journal article 2017
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Kolken, H.M.A. (author), Zadpoor, A.A. (author)The surge of interest in so-called "designer materials" during the last few years together with recent advances in additive manufacturing (3D printing) techniques that enable fabrication of materials with arbitrarily complex nano/micro-architecture have attracted increasing attention to the concept of mechanical metamaterials. Owing to their...journal article 2017
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Rahnamay Moshtagh, P. (author), Korthagen, Nicoline M. (author), Plomp, Saskia G. (author), Pouran, B. (author), Castelein, Rene M. (author), Zadpoor, A.A. (author), Weinans, Harrie (author)This study aims to investigate the earliest alterations of bone and cartilage tissues as a result of different exercise protocols in the knee joint of Wistar rats. We hypothesize that pretraining to a continuous intense running protocol would protect the animals from cartilage degeneration. Three groups of animals were used: (i) an adaptive ...journal article 2018
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Kolken, H.M.A. (author), Janbaz, S. (author), Leeflang, M.A. (author), Lietaert, K. (author), Weinans, Harrie (author), Zadpoor, A.A. (author)Rationally designed meta-biomaterials present unprecedented combinations of mechanical, mass transport, and biological properties favorable for tissue regeneration. Here we introduce hybrid meta-biomaterials with rationally-distributed values of negative (auxetic) and positive Poisson’s ratios, and use them to design meta-implants that unlike...journal article 2018
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Mirzaali, Mohammad J. (author), Janbaz, S. (author), Strano, M. (author), Vergani, L. (author), Zadpoor, A.A. (author)Architectured materials with rationally designed geometries could be used to create mechanical metamaterials with unprecedented or rare properties and functionalities. Here, we introduce "shape-matching" metamaterials where the geometry of cellular structures comprising auxetic and conventional unit cells is designed so as to achieve a pre...journal article 2018
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Li, Y. (author), Zhou, J. (author), Pavanram, P. (author), Leeflang, M.A. (author), Fockaert, L.I. (author), Pouran, B. (author), Tümer, N. (author), Schröder, K. U. (author), Mol, J.M.C. (author), Weinans, Harrie (author), Jahr, H. (author), Zadpoor, A.A. (author)An ideal bone substituting material should be bone-mimicking in terms of mechanical properties, present a precisely controlled and fully interconnected porous structure, and degrade in the human body to allow for full regeneration of large bony defects. However, simultaneously satisfying all these three requirements has so far been highly...journal article 2017
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Tümer, N. (author), Arbabi, V. (author), Gielis, Willem Paul (author), de Jong, Pim A. (author), Weinans, Harrie (author), Tuijthof, Gabrielle J.M. (author), Zadpoor, A.A. (author)The bones forming the talocrural joint (TCJ) and subtalar joint (STJ) are often assumed to be bilaterally symmetric. Therefore, the contralateral limb (i.e. the fibula, tibia, calcaneus and talus) is used as a template or an intra-subject control in clinical and research practice. However, the validity of the symmetry assumption is...journal article 2019
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Isaakidou, A. (author), Ganjian, M. (author), van Hoften, R. (author), Cruz Saldivar, M. (author), Leeflang, M.A. (author), Groetsch, A. (author), Wątroba, M. (author), Schwiedrzik, J. (author), Mirzaali, Mohammad J. (author), Apachitei, I. (author), Fratila-Apachitei, E.L. (author), Zadpoor, A.A. (author)The currently available treatments for inner ear disorders often involve systemic drug administration, leading to suboptimal drug concentrations and side effects. Cochlear implants offer a potential solution by providing localized and sustained drug delivery to the cochlea. While the mechanical characterization of both the implants and their...journal article 2024
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Deep Learning for Size-Agnostic Inverse Design of Random-Network 3D Printed Mechanical MetamaterialsPahlavani, H. (author), Tsifoutis-Kazolis, Kostas (author), Cruz Saldivar, M. (author), Mody, Prerak (author), Zhou, J. (author), Mirzaali, Mohammad J. (author), Zadpoor, A.A. (author)Practical applications of mechanical metamaterials often involve solving inverse problems aimed at finding microarchitectures that give rise to certain properties. The limited resolution of additive manufacturing techniques often requires solving such inverse problems for specific specimen sizes. Moreover, the candidate microarchitectures...journal article 2023
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van Hengel, I.A.J. (author), van Dijk, B. (author), Modaresifar, K. (author), Hooning van Duyvenbode, J. Fred F. (author), Nurmohamed, F. Ruben H.A. (author), Leeflang, M.A. (author), Fluit, A.C. (author), Fratila-Apachitei, E.L. (author), Apachitei, I. (author), Weinans, Harrie (author), Zadpoor, A.A. (author)Additively manufactured (AM) porous titanium implants may have an increased risk of implant-associated infection (IAI) due to their huge internal surfaces. However, the same surface, when biofunctionalized, can be used to prevent IAI. Here, we used a rat implant infection model to evaluate the biocompatibility and infection prevention...journal article 2023
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Isaakidou, A. (author), Apachitei, I. (author), Fratila-Apachitei, E.L. (author), Zadpoor, A.A. (author)Hearing loss is a highly prevalent multifactorial disorder affecting 20% of the global population. Current treatments using the systemic administration of drugs are therapeutically ineffective due to the anatomy of the cochlea and the existing blood–labyrinth barrier. Local drug delivery systems can ensure therapeutic drug concentrations locally...journal article 2023
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Garmendia Urdalleta, A. (author), van Poll, M.A. (author), Fahy, Niamh (author), Witte-Bouma, Janneke (author), van Wamel, Willem (author), Apachitei, I. (author), Zadpoor, A.A. (author), Fratila-Apachitei, E.L. (author), Farrell, Eric (author)Macrophage responses following the implantation of orthopaedic implants are essential for successful implant integration in the body, partly through intimate crosstalk with human marrow stromal cells (hMSCs) in the process of new bone formation. Additive manufacturing (AM) and plasma electrolytic oxidation (PEO) in the presence of silver...journal article 2023
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Yu, K. (author), Balasubramanian, S. (author), Pahlavani, H. (author), Mirzaali, Mohammad J. (author), Zadpoor, A.A. (author), Aubin-Tam, M.E. (author)Natural materials, such as nacre and silk, exhibit both high strength and toughness due to their hierarchical structures highly organized at the nano-, micro-, and macroscales. Bacterial cellulose (BC) presents a hierarchical fibril structure at the nanoscale. At the microscale, however, BC nanofibers are distributed randomly. Here, BC self...journal article 2020
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Cuellar Lopez, J.S. (author), Plettenburg, D.H. (author), Zadpoor, A.A. (author), Breedveld, P. (author), Smit, G. (author)Various upper-limb prostheses have been designed for 3D printing but only a few of them are based on bio-inspired design principles and many anatomical details are not typically incorporated even though 3D printing offers advantages that facilitate the application of such design principles. We therefore aimed to apply a bio-inspired approach...journal article 2021
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Putra, N.E. (author), Leeflang, M.A. (author), Minneboo, M.B. (author), Taheri, P. (author), Fratila-Apachitei, E.L. (author), Mol, J.M.C. (author), Zhou, J. (author), Zadpoor, A.A. (author)Extrusion-based 3D printing followed by debinding and sintering is a powerful approach that allows for the fabrication of porous scaffolds from materials (or material combinations) that are otherwise very challenging to process using other additive manufacturing techniques. Iron is one of the materials that have been recently shown to be...journal article 2021
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Dong, J. (author), Tümer, N. (author), Leeflang, M.A. (author), Taheri, P. (author), Fratila-Apachitei, E.L. (author), Mol, J.M.C. (author), Zadpoor, A.A. (author), Zhou, J. (author)Porous biodegradable Mg and its alloys are considered to have a great potential to serve as ideal bone substitutes. The recent progress in additive manufacturing (AM) has prompted its application to fabricate Mg scaffolds with geometrically ordered porous structures. Extrusion-based AM, followed by debinding and sintering, has been recently...journal article 2022