- document
-
Garner, E. (author)Background: Despite over a century’s worth of technical improvements, the longterm survivability associated with orthopedic implants continues to fall short. In contrast to earlier designs, implant failure is no longer caused by structural failure of the implant itself. Rather, it results from the implant’s long-term detrimental effects on the...doctoral thesis 2024
- document
- Pahlavani, H. (author) doctoral thesis 2023
- document
-
Cruz Saldivar, M. (author)In the vast domain of biomedical engineering, the challenge of developing synthetic materials that can replace damaged tissues has proved a daunting task. Millions of years of adaptation have provided natural tissues with multiple strategies that yield highly efficient mechanical properties that are not found in human-made materials. The first...doctoral thesis 2023
- document
-
Dong, J. (author)The treatment of largy bone defect remains challenging in clinics. All the clinically available bone grafts have their own limitations and are not ideal for the treatment. Therefore, developing a new generation of suitable bone substitutes is urgently needed. In the recent years, porous magnesium (Mg) has been extensively studied for orthopedic...doctoral thesis 2023
- document
-
Putra, N.E. (author)The treatment of large bone injuries continues to be challenging partially due to the limited quantity and quality of bone-replacing materials. Iron (Fe) and its alloys have been developed as a group of load-bearing biomaterials. Recent advances in additive manufacturing (AM) have enhanced the potential of Fe-based biomaterials as biodegradable...doctoral thesis 2023
- document
-
van Manen, T. (author)An important goal of bone tissue engineering is the development of synthetic bio-scaffolds that would eliminate the need for bone transplantation, also known as bone grafting. Bone grafting is associated with some serious limitations such, as morbidity at the donor-site and shortage of donor tissue. Therefore, scientist have been trying to...doctoral thesis 2022
- document
-
van Hengel, I.A.J. (author)Millions of people around the globe receive orthopedic implants every year. These implants help people to regain their mobility and contribute tremendously to improve the quality of life. However, a significant number of patients suffer from complications, such as implant associated infections (IAI) and aseptic loosening. The number of...doctoral thesis 2022
- document
- Modaresifar, K. (author) doctoral thesis 2022
- document
-
Nouri Goushki, M. (author)Osteoimmunomodulation (OIM) is a mechanism through which orthopedic biomaterials may modulate the function of immune cells to promote osteogenesis. OIM is considered a potentially effective way for improving osseointegration. The surface characteristics of orthopedic implants (e.g., topography, wettability, surface chemistry, and charge) can...doctoral thesis 2022
- document
-
Kolken, H.M.A. (author)Since the beginning of time, humans have been trying to replace the skeletal system in cases of trauma or disease. Medical devices were designed, manufactured, and implanted, to restore the function of the skeletal system. Fast forward to today and joint replacements are among the most common surgeries carried out in the world. Despite their...doctoral thesis 2022
- document
-
Ganjian, M. (author)Recurrent bacterial infection is one of the main reasons of implant failure, hugely impacting the patients’ quality of life, and ultimately resulting in morbidity and even mortality. This type of infection starts with the attachment of the bacteria to the implant surface, leading to biofilm formation and, thus, high resistance against...doctoral thesis 2022
- document
-
Bobbert, F.S.L. (author)Without our musculoskeletal system, which consists of bones, joints, and muscles, we would not be able to live. Our bones are responsible for the protection of our organs, the support of our body, and they enable our mobility. Therefore, it is important to keep them healthy. This is done by cells who repair small cracks and fractures caused by...doctoral thesis 2021
- document
-
Callens, S.J.P. (author)The rapidly expanding field of tissue engineering presents enticing, yet demanding challenges for scientists and engineers across many different disciplines. The ultimate goal of tissue engineering is ambitious: to regenerate damaged or missing tissue in its full complexity, either in vitro or in situ, and restore organ function. In addition to...doctoral thesis 2021
- document
-
Cuellar Lopez, J.S. (author)The World Health Organization (WHO) estimates that there are ≈40 million amputees in developing countries and that only ≈5% of them have access to prosthetic devices. In low income countries, there are only a few big cities capable of providing reasonable healthcare services and transportation from rural areas is usually complicated, expensive,...doctoral thesis 2021
- document
-
Li, Y. (author)For the treatment of large bony defects, no perfect solution has been yet found, partially due to the unavailability of ideal bone implants. Additively manufactured (AM) biodegradable porous metals provide unprecedented opportunities to fulfil the requirements for ideal bone implants to be used in such treatments. Firstly, the multi-scale...doctoral thesis 2020
- document
- Tümer, N. (author) doctoral thesis 2018
- document
-
Janbaz, S. (author)Nature is full of materials that exhibit astonishing properties that are not available in engineering materials. The study of the underlying structure of such materials has revealed that geometry plays an important role in achieving such properties. Unusual physical and mechanical properties such as structural coloring in butterfly wings and...doctoral thesis 2018
- document
-
Ahmadi, S.M. (author)One of the main functions of bone is to support the human body mechanically. To fulfil its complex role, bone possesses unique mechanical properties: it is stiff enough to resist deformation while being able to absorb energy.<br/>In this thesis, a comprehensive study has been carried out using analytical methods, numerical methods and...doctoral thesis 2018
- document
- Campoli, G. (author) doctoral thesis 2014