Accurate Coregistration between Ultra-High-Resolution Micro-SPECT and Circular Cone-BeamMicro-CT Scanners

Spatially registering SPECT with CT makes it possible to anatomically localize SPECT tracers. In this study, an accurate method for the coregistration of ultra-high-resolution SPECT volumes andmultiple cone-beam CT volumes is developed and validated, which does not require markers during animal scanning. Methods. Transferable animal beds were...

3-D Rat Brain Phantom for High-Resolution Molecular Imaging: Experimental studies aimed at advancing understanding of human brain disease and malfunction, and of behavior problems, may be aided by computer models of small laboratory animals

With the steadily improving resolution of novel small-animal single photon emission computed tomography (SPECT) and positron emission tomography devices, highly detailed phantoms are required for testing and optimizing these systems. We present a three-dimensional (3-D) digital and physical phantom pair to represent, e.g., cerebral blood flow,...

U-SPECT-II: An Ultra-High-Resolution Device for Molecular Small-Animal Imaging

We present a new rodent SPECT system (U-SPECT-II) that enables molecular imaging of murine organs down to resolutions of less than half a millimeter and high-resolution total-body imaging. Methods: The U-SPECT-II is based on a triangular stationary detector set-up, an XYZ stage that moves the animal during scanning, and interchangeable cylindric...