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Laan, A.C. (author), Santini, C. (author), Jennings, L. (author), De Jong, M. (author), Bernsen, M.R. (author), Denkova, A.G. (author)Background Single photon emission computed tomography (SPECT) is an indispensable tool in the determination of the in vivo fate of polymeric micelles. However, for this purpose, the micelles need to be radiolabeled, and almost all radiolabeling procedures published to date involve the conjugation of a chelating agent to the constituting polymer,...journal article 2016
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Boonstra, M.C. (author), Van Driel, P.B.A.A. (author), Van Willigen, D.M. (author), Stammes, M.A. (author), Prevoo, H.A.J.M. (author), Tummers, Q.R.J.G. (author), Mazar, A.P. (author), Beekman, F.J. (author), Kuppen, P.J.K. (author), Van de Velde, C.J.H. (author), Löwik, C.W.G.M. (author), Frangioni, J.V. (author), Van Leeuwen, F.W.B. (author), Sier, C.F.M. (author), Vahrmeijer, A.L. (author)Pre- and intraoperative diagnostic techniques facilitating tumor staging are of paramount importance in colorectal cancer surgery. The urokinase receptor (uPAR) plays an important role in the development of cancer, tumor invasion, angiogenesis, and metastasis and over-expression is found in the majority of carcinomas. This study aims to develop...journal article 2015
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Van Oosterom, M.N. (author), Kreuger, R. (author), Buckle, T. (author), Mahn, W.A. (author), Bunschoten, A. (author), Josephson, L. (author), Van Leeuwen, F.W.B. (author), Beekman, F.J. (author)Background: In vivo bioluminescence, fluorescence, and single-photon emission computed tomography (SPECT) imaging provide complementary information about biological processes. However, to date these signatures are evaluated separately on individual preclinical systems. In this paper, we introduce a fully integrated bioluminescence-fluorescence...journal article 2014
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Vaissier, P.E.B. (author)Nowadays, tomographic imaging techniques are inseparable from modern medical practice as they allow non-invasive 3-dimensional visualization of the interior of a patient in order to e.g. establish a medical diagnosis, or to monitor disease progression and the effects of disease treatment. Next to clinical use, tomographic imaging techniques are...doctoral thesis 2014
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Wu, C. (author), Gratama van Andel, H.A. (author), Laverman, P. (author), Boerman, O.C. (author), Beekman, F.J. (author)Background In single-photon emission computed tomography (SPECT), attenuation of photon flux in tissue affects quantitative accuracy of reconstructed images. Attenuation maps derived from X-ray computed tomography (CT) can be employed for attenuation correction. The attenuation coefficients as well as registration accuracy between SPECT and CT...journal article 2013
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Branderhorst, W. (author), Vastenhouw, B. (author), Van der Have, F. (author), Blezer, E.L.A. (author), Bleeker, W.K. (author), Beekman, F.J. (author)Purpose: Small-animal single photon emission computed tomography (SPECT) with focused multi-pinhole collimation geometries allows scanning modes in which large amounts of photons can be collected from specific volumes of interest. Here we present new tools that improve targeted imaging of specific organs and tumours, and validate the effects of...journal article 2010
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Wu, C. (author), Van der Have, F. (author), Vastenhouw, B. (author), Dierckx, R.A.J.O. (author), Paans, A.M.J. (author), Beekman, F.J. (author)Purpose: In pinhole SPECT, attenuation of the photon flux on trajectories between source and pinholes affects quantitative accuracy of reconstructed images. Previously we introduced iterative methods that compensate for image degrading effects of detector and pinhole blurring, pinhole sensitivity and scatter for multi-pinhole SPECT. The aim of...journal article 2010
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Westra, A.H. (author), Heemskerk, J.W.T. (author), Korevaar, M.A.N. (author), Theuwissen, A.J.P. (author), Kreuger, R. (author), Ligtvoet, K.M. (author), Beekman, F.J. (author)Charge Coupled Devices (CCDs) optically coupled to scintillation crystals can be used to construct high resolution gamma cameras. Previously, several groups have reported intrinsic detector spatial resolutions below 100 microns. When the CCD images can be read out fast enough, the energy and interaction position of individual gamma quanta can be...journal article 2009
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Van der Have, F. (author), Vastenhouw, B. (author), Ramakers, R.M. (author), Branderhorst, W. (author), Krah, J.O. (author), Ji, C. (author), Staelens, S.G. (author), Beekman, F.J. (author)We present a new rodent SPECT system (U-SPECT-II) that enables molecular imaging of murine organs down to resolutions of less than half a millimeter and high-resolution total-body imaging. Methods: The U-SPECT-II is based on a triangular stationary detector set-up, an XYZ stage that moves the animal during scanning, and interchangeable cylindric...journal article 2009
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Zielhuis, S.W. (author), Seppenwoolde, J.H. (author), Mateus, V.A.P. (author), Bakker, C.J.G. (author), Krijger, G.C. (author), Storm, G. (author), Zonnenberg, B.A. (author), Van het Schip, A.D. (author), Koning, G.A. (author), Nijsen, J.F.W. (author)Many advanced molecular imaging agents are currently being investigated preclinically. Especially, liposomes, have proven to be very promising carrier systems for diagnostic agents for use in single-photon emission computed tomography (SPECT) or magnetic resonance imaging (MRI), as well as for therapeutic agents to treat diseases such as cancer....journal article 2006